Exposures that may affect sperm DNA integrity: Two decades of follow-up in a pregnancy cohort
► Sons of overweight mothers had 22% (95% CI: −3; 52) higher DFI than sons of normal weight mothers. ► Sons of parents with a TTP of >12 months had 14% (95% CI: −4; 34) higher DFI than sons of parents with a TTP of 0–6 months. ► Abstinence time was associated with DFI (p for trend6 days had 87% (...
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| Veröffentlicht in: | Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2012-06, Vol.33 (3), p.316-321 |
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| creator | Håkonsen, L.B. Spano, M. Bonde, J.P. Olsen, J. Thulstrup, A.M. Ernst, E. Ramlau-Hansen, C.H. |
| description | ► Sons of overweight mothers had 22% (95% CI: −3; 52) higher DFI than sons of normal weight mothers. ► Sons of parents with a TTP of >12 months had 14% (95% CI: −4; 34) higher DFI than sons of parents with a TTP of 0–6 months. ► Abstinence time was associated with DFI (p for trend6 days had 87% (95% CI: 47; 138) higher DFI than the group of men with 1–2 days of abstinence. ► The son's own cigarette smoking was not associated with DFI. ► Maternal cigarette smoking during pregnancy was not associated with DFI.
Prenatal lifestyle exposures are linked to alterations in conventional semen characteristics. Sperm DNA integrity is another marker of semen quality shown to be altered in mice prenatally exposed to chemicals. From a Danish pregnancy cohort established in 1984–1987, sons were selected for a follow-up study in 2005–2006. We examined associations between prenatal and current lifestyle exposures and DNA fragmentation index (DFI) among 337 men. Sons of overweight mothers had 22% (95% CI: −3; 52) higher DFI than sons of normal weight mothers and sons of parents with a TTP >12 months had 14% (95% CI: −4; 34) higher DFI than sons of parents with a TTP of 0–6 months. Abstinence time was positively associated with DFI (p |
| doi_str_mv | 10.1016/j.reprotox.2011.12.013 |
| format | Article |
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Prenatal lifestyle exposures are linked to alterations in conventional semen characteristics. Sperm DNA integrity is another marker of semen quality shown to be altered in mice prenatally exposed to chemicals. From a Danish pregnancy cohort established in 1984–1987, sons were selected for a follow-up study in 2005–2006. We examined associations between prenatal and current lifestyle exposures and DNA fragmentation index (DFI) among 337 men. Sons of overweight mothers had 22% (95% CI: −3; 52) higher DFI than sons of normal weight mothers and sons of parents with a TTP >12 months had 14% (95% CI: −4; 34) higher DFI than sons of parents with a TTP of 0–6 months. Abstinence time was positively associated with DFI (p<0.005). Overweight men had higher DFI compared to normal weight men, however, statistically insignificantly. In conclusion, results indicate that DFI is affected by prenatal exposures, but confidence limits are wide and results statistically insignificant.</description><identifier>ISSN: 0890-6238</identifier><identifier>EISSN: 1873-1708</identifier><identifier>DOI: 10.1016/j.reprotox.2011.12.013</identifier><identifier>PMID: 22230645</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Alcohol Drinking ; Biological and medical sciences ; Body Weight ; Coffee ; Cohort Studies ; DNA Fragmentation ; Embryology: invertebrates and vertebrates. Teratology ; Environmental Exposure ; Female ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Humans ; Life Style ; Male ; Maternal-Fetal Exchange ; Medical sciences ; Pregnancy ; Prenatal Exposure Delayed Effects ; Prenatal exposures ; Prenatal smoking exposure ; SCSA ; Semen quality ; Sexual Abstinence ; Smoking ; Sperm DNA integrity ; Spermatozoa - physiology ; Tea ; Teratology. Teratogens ; Tobacco, tobacco smoking ; Toxicology ; Young Adult</subject><ispartof>Reproductive toxicology (Elmsford, N.Y.), 2012-06, Vol.33 (3), p.316-321</ispartof><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-154da98a824e5ac1fff05ecd37ed16c5f4ef72889e42b6905c30ccbcf98294f63</citedby><cites>FETCH-LOGICAL-c398t-154da98a824e5ac1fff05ecd37ed16c5f4ef72889e42b6905c30ccbcf98294f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.reprotox.2011.12.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25884427$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22230645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Håkonsen, L.B.</creatorcontrib><creatorcontrib>Spano, M.</creatorcontrib><creatorcontrib>Bonde, J.P.</creatorcontrib><creatorcontrib>Olsen, J.</creatorcontrib><creatorcontrib>Thulstrup, A.M.</creatorcontrib><creatorcontrib>Ernst, E.</creatorcontrib><creatorcontrib>Ramlau-Hansen, C.H.</creatorcontrib><title>Exposures that may affect sperm DNA integrity: Two decades of follow-up in a pregnancy cohort</title><title>Reproductive toxicology (Elmsford, N.Y.)</title><addtitle>Reprod Toxicol</addtitle><description>► Sons of overweight mothers had 22% (95% CI: −3; 52) higher DFI than sons of normal weight mothers. ► Sons of parents with a TTP of >12 months had 14% (95% CI: −4; 34) higher DFI than sons of parents with a TTP of 0–6 months. ► Abstinence time was associated with DFI (p for trend<0.005) and the group of men with abstinence time >6 days had 87% (95% CI: 47; 138) higher DFI than the group of men with 1–2 days of abstinence. ► The son's own cigarette smoking was not associated with DFI. ► Maternal cigarette smoking during pregnancy was not associated with DFI.
Prenatal lifestyle exposures are linked to alterations in conventional semen characteristics. Sperm DNA integrity is another marker of semen quality shown to be altered in mice prenatally exposed to chemicals. From a Danish pregnancy cohort established in 1984–1987, sons were selected for a follow-up study in 2005–2006. We examined associations between prenatal and current lifestyle exposures and DNA fragmentation index (DFI) among 337 men. Sons of overweight mothers had 22% (95% CI: −3; 52) higher DFI than sons of normal weight mothers and sons of parents with a TTP >12 months had 14% (95% CI: −4; 34) higher DFI than sons of parents with a TTP of 0–6 months. Abstinence time was positively associated with DFI (p<0.005). Overweight men had higher DFI compared to normal weight men, however, statistically insignificantly. In conclusion, results indicate that DFI is affected by prenatal exposures, but confidence limits are wide and results statistically insignificant.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Alcohol Drinking</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Coffee</subject><subject>Cohort Studies</subject><subject>DNA Fragmentation</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Environmental Exposure</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Life Style</subject><subject>Male</subject><subject>Maternal-Fetal Exchange</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Prenatal exposures</subject><subject>Prenatal smoking exposure</subject><subject>SCSA</subject><subject>Semen quality</subject><subject>Sexual Abstinence</subject><subject>Smoking</subject><subject>Sperm DNA integrity</subject><subject>Spermatozoa - physiology</subject><subject>Tea</subject><subject>Teratology. Teratogens</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><subject>Young Adult</subject><issn>0890-6238</issn><issn>1873-1708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E9vFCEYx3FiNHatvoWGi4mXGYFhZsCTTa1_kkYv9WgI-8xDy2ZmGIFpu-9emt3q0ROXzw_Il5AzzmrOePd-V0dcYsjhoRaM85qLmvHmGdlw1TcV75l6TjZMaVZ1olEn5FVKO8aY7HX_kpwIIRrWyXZDfl0-LCGtERPNtzbTye6pdQ4h07RgnOin7-fUzxlvos_7D_T6PtABwQ5lEBx1YRzDfbUuxVBLl4g3s51hTyHchphfkxfOjgnfHM9T8vPz5fXF1-rqx5dvF-dXFTRa5Yq3crBaWSUktha4c461CEPT48A7aJ1E1wulNEqx7TRroWEAW3BaCS1d15ySd4d7S5LfK6ZsJp8Ax9HOGNZkOGNct53sVaHdgUIMKUV0Zol-snFfkHlMa3bmKa15TGu4MCVtGZ4d31i3Ew5_Z08tC3h7BDaBHV0sIXz651qlpBR9cR8PDkuRO4_RJPA4Aw4-lu5mCP5_f_kDgPGbtQ</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Håkonsen, L.B.</creator><creator>Spano, M.</creator><creator>Bonde, J.P.</creator><creator>Olsen, J.</creator><creator>Thulstrup, A.M.</creator><creator>Ernst, E.</creator><creator>Ramlau-Hansen, C.H.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120601</creationdate><title>Exposures that may affect sperm DNA integrity: Two decades of follow-up in a pregnancy cohort</title><author>Håkonsen, L.B. ; Spano, M. ; Bonde, J.P. ; Olsen, J. ; Thulstrup, A.M. ; Ernst, E. ; Ramlau-Hansen, C.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-154da98a824e5ac1fff05ecd37ed16c5f4ef72889e42b6905c30ccbcf98294f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Alcohol Drinking</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Coffee</topic><topic>Cohort Studies</topic><topic>DNA Fragmentation</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Environmental Exposure</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Life Style</topic><topic>Male</topic><topic>Maternal-Fetal Exchange</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Prenatal exposures</topic><topic>Prenatal smoking exposure</topic><topic>SCSA</topic><topic>Semen quality</topic><topic>Sexual Abstinence</topic><topic>Smoking</topic><topic>Sperm DNA integrity</topic><topic>Spermatozoa - physiology</topic><topic>Tea</topic><topic>Teratology. Teratogens</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Håkonsen, L.B.</creatorcontrib><creatorcontrib>Spano, M.</creatorcontrib><creatorcontrib>Bonde, J.P.</creatorcontrib><creatorcontrib>Olsen, J.</creatorcontrib><creatorcontrib>Thulstrup, A.M.</creatorcontrib><creatorcontrib>Ernst, E.</creatorcontrib><creatorcontrib>Ramlau-Hansen, C.H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Håkonsen, L.B.</au><au>Spano, M.</au><au>Bonde, J.P.</au><au>Olsen, J.</au><au>Thulstrup, A.M.</au><au>Ernst, E.</au><au>Ramlau-Hansen, C.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exposures that may affect sperm DNA integrity: Two decades of follow-up in a pregnancy cohort</atitle><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle><addtitle>Reprod Toxicol</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>33</volume><issue>3</issue><spage>316</spage><epage>321</epage><pages>316-321</pages><issn>0890-6238</issn><eissn>1873-1708</eissn><abstract>► Sons of overweight mothers had 22% (95% CI: −3; 52) higher DFI than sons of normal weight mothers. ► Sons of parents with a TTP of >12 months had 14% (95% CI: −4; 34) higher DFI than sons of parents with a TTP of 0–6 months. ► Abstinence time was associated with DFI (p for trend<0.005) and the group of men with abstinence time >6 days had 87% (95% CI: 47; 138) higher DFI than the group of men with 1–2 days of abstinence. ► The son's own cigarette smoking was not associated with DFI. ► Maternal cigarette smoking during pregnancy was not associated with DFI.
Prenatal lifestyle exposures are linked to alterations in conventional semen characteristics. Sperm DNA integrity is another marker of semen quality shown to be altered in mice prenatally exposed to chemicals. From a Danish pregnancy cohort established in 1984–1987, sons were selected for a follow-up study in 2005–2006. We examined associations between prenatal and current lifestyle exposures and DNA fragmentation index (DFI) among 337 men. Sons of overweight mothers had 22% (95% CI: −3; 52) higher DFI than sons of normal weight mothers and sons of parents with a TTP >12 months had 14% (95% CI: −4; 34) higher DFI than sons of parents with a TTP of 0–6 months. Abstinence time was positively associated with DFI (p<0.005). Overweight men had higher DFI compared to normal weight men, however, statistically insignificantly. In conclusion, results indicate that DFI is affected by prenatal exposures, but confidence limits are wide and results statistically insignificant.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>22230645</pmid><doi>10.1016/j.reprotox.2011.12.013</doi><tpages>6</tpages></addata></record> |
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| ispartof | Reproductive toxicology (Elmsford, N.Y.), 2012-06, Vol.33 (3), p.316-321 |
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| subjects | Adolescent Adult Alcohol Drinking Biological and medical sciences Body Weight Coffee Cohort Studies DNA Fragmentation Embryology: invertebrates and vertebrates. Teratology Environmental Exposure Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Humans Life Style Male Maternal-Fetal Exchange Medical sciences Pregnancy Prenatal Exposure Delayed Effects Prenatal exposures Prenatal smoking exposure SCSA Semen quality Sexual Abstinence Smoking Sperm DNA integrity Spermatozoa - physiology Tea Teratology. Teratogens Tobacco, tobacco smoking Toxicology Young Adult |
| title | Exposures that may affect sperm DNA integrity: Two decades of follow-up in a pregnancy cohort |
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