Carcinoma cuniculatum mimicking leukoplakia of the mandibular gingiva
Abstract Carcinoma cuniculatum (CC) is a rare variant of low-grade squamous cell carcinoma (SCC), and occurrence in the oral cavity is quite unusual. CC has a papillomatous keratinized surface like verrucous carcinoma, but CC has a propensity for aggressive local invasion, especially into the bone....
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| Veröffentlicht in: | Auris, nasus, larynx nasus, larynx, 2012-06, Vol.39 (3), p.321-325 |
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| creator | Suzuki, Jun Hashimoto, Sho Watanabe, Ken-ichi Takahashi, Kaoru Usubuchi, Hajime Suzuki, Hiroyoshi |
| description | Abstract Carcinoma cuniculatum (CC) is a rare variant of low-grade squamous cell carcinoma (SCC), and occurrence in the oral cavity is quite unusual. CC has a papillomatous keratinized surface like verrucous carcinoma, but CC has a propensity for aggressive local invasion, especially into the bone. Therefore, CC can be quite difficult to remove surgically. A 68-year-old man presented with a case of CC mimicking verrucous leukoplakia in the mandibular gingiva. Repeated biopsies showed no malignancy. Local resection was performed, and histological examination revealed the presence of well-differentiated SCC. Additional hemi-mandibulectomy was performed and the final histological diagnosis was CC. Local recurrence was detected at the 14-month follow-up examination. Chemotherapy with docetaxel was not effective, and he died of aspiration pneumonia. CC of the oral cavity is a rare entity and the diagnosis is hard to establish. Misdiagnosis could result in inadequate removal and local recurrence. Complete resection with a safety margin is essential because of the tendency for local invasion. |
| doi_str_mv | 10.1016/j.anl.2011.06.004 |
| format | Article |
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CC has a papillomatous keratinized surface like verrucous carcinoma, but CC has a propensity for aggressive local invasion, especially into the bone. Therefore, CC can be quite difficult to remove surgically. A 68-year-old man presented with a case of CC mimicking verrucous leukoplakia in the mandibular gingiva. Repeated biopsies showed no malignancy. Local resection was performed, and histological examination revealed the presence of well-differentiated SCC. Additional hemi-mandibulectomy was performed and the final histological diagnosis was CC. Local recurrence was detected at the 14-month follow-up examination. Chemotherapy with docetaxel was not effective, and he died of aspiration pneumonia. CC of the oral cavity is a rare entity and the diagnosis is hard to establish. Misdiagnosis could result in inadequate removal and local recurrence. Complete resection with a safety margin is essential because of the tendency for local invasion.</description><identifier>ISSN: 0385-8146</identifier><identifier>EISSN: 1879-1476</identifier><identifier>DOI: 10.1016/j.anl.2011.06.004</identifier><identifier>PMID: 21862267</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>Aged ; Carcinoma cuniculatum ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; Diagnosis, Differential ; Humans ; Leukoplakia, Oral - diagnosis ; Leukoplakia, Oral - pathology ; Male ; Mandible ; Mandible - pathology ; Mouth Neoplasms - diagnosis ; Mouth Neoplasms - pathology ; Mouth Neoplasms - surgery ; Neoplasm Recurrence, Local ; Oral cavity ; Otolaryngology</subject><ispartof>Auris, nasus, larynx, 2012-06, Vol.39 (3), p.321-325</ispartof><rights>2011</rights><rights>Copyright © 2011. Published by Elsevier Ireland Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-4088b592de8c7c8a5d90abf0fc2bda87c82443675062ba39155103b10eb896e13</citedby><cites>FETCH-LOGICAL-c432t-4088b592de8c7c8a5d90abf0fc2bda87c82443675062ba39155103b10eb896e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.anl.2011.06.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21862267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suzuki, Jun</creatorcontrib><creatorcontrib>Hashimoto, Sho</creatorcontrib><creatorcontrib>Watanabe, Ken-ichi</creatorcontrib><creatorcontrib>Takahashi, Kaoru</creatorcontrib><creatorcontrib>Usubuchi, Hajime</creatorcontrib><creatorcontrib>Suzuki, Hiroyoshi</creatorcontrib><title>Carcinoma cuniculatum mimicking leukoplakia of the mandibular gingiva</title><title>Auris, nasus, larynx</title><addtitle>Auris Nasus Larynx</addtitle><description>Abstract Carcinoma cuniculatum (CC) is a rare variant of low-grade squamous cell carcinoma (SCC), and occurrence in the oral cavity is quite unusual. CC has a papillomatous keratinized surface like verrucous carcinoma, but CC has a propensity for aggressive local invasion, especially into the bone. Therefore, CC can be quite difficult to remove surgically. A 68-year-old man presented with a case of CC mimicking verrucous leukoplakia in the mandibular gingiva. Repeated biopsies showed no malignancy. Local resection was performed, and histological examination revealed the presence of well-differentiated SCC. Additional hemi-mandibulectomy was performed and the final histological diagnosis was CC. Local recurrence was detected at the 14-month follow-up examination. Chemotherapy with docetaxel was not effective, and he died of aspiration pneumonia. CC of the oral cavity is a rare entity and the diagnosis is hard to establish. Misdiagnosis could result in inadequate removal and local recurrence. Complete resection with a safety margin is essential because of the tendency for local invasion.</description><subject>Aged</subject><subject>Carcinoma cuniculatum</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Diagnosis, Differential</subject><subject>Humans</subject><subject>Leukoplakia, Oral - diagnosis</subject><subject>Leukoplakia, Oral - pathology</subject><subject>Male</subject><subject>Mandible</subject><subject>Mandible - pathology</subject><subject>Mouth Neoplasms - diagnosis</subject><subject>Mouth Neoplasms - pathology</subject><subject>Mouth Neoplasms - surgery</subject><subject>Neoplasm Recurrence, Local</subject><subject>Oral cavity</subject><subject>Otolaryngology</subject><issn>0385-8146</issn><issn>1879-1476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUGL1TAQx4Mo7nP1A3iRHr20O5O0aYIgyGPVhQUP6jmk6XTNe2n7TNqF_fab8lYPHjwNDL__H-Y3jL1FqBBQXh0qO4WKA2IFsgKon7EdqlaXWLfyOduBUE2psJYX7FVKBwAQrdAv2QVHJTmX7Y5d7210fppHW7h18m4NdlnHYvSjd0c_3RWB1uN8CvbobTEPxfKLitFOve8yGYu7jPh7-5q9GGxI9OZpXrKfn69_7L-Wt9--3Ow_3ZauFnwpa1CqazTvSbnWKdv0Gmw3wOB411uVV7yuhWwbkLyzQmPTIIgOgTqlJaG4ZO_Pvac4_14pLWb0yVEIdqJ5TQYBUDdNCzyjeEZdnFOKNJhT9KONDxkymz1zMNme2ewZkCbby5l3T_VrN1L_N_FHVwY-nAHKR957iiY5T5Oj3kdyi-ln_9_6j_-kXfDZuQ1HeqB0mNc4ZXsGTeIGzPftfdv3cDur1Vo8AsmWlBQ</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Suzuki, Jun</creator><creator>Hashimoto, Sho</creator><creator>Watanabe, Ken-ichi</creator><creator>Takahashi, Kaoru</creator><creator>Usubuchi, Hajime</creator><creator>Suzuki, Hiroyoshi</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120601</creationdate><title>Carcinoma cuniculatum mimicking leukoplakia of the mandibular gingiva</title><author>Suzuki, Jun ; Hashimoto, Sho ; Watanabe, Ken-ichi ; Takahashi, Kaoru ; Usubuchi, Hajime ; Suzuki, Hiroyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-4088b592de8c7c8a5d90abf0fc2bda87c82443675062ba39155103b10eb896e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Carcinoma cuniculatum</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Diagnosis, Differential</topic><topic>Humans</topic><topic>Leukoplakia, Oral - diagnosis</topic><topic>Leukoplakia, Oral - pathology</topic><topic>Male</topic><topic>Mandible</topic><topic>Mandible - pathology</topic><topic>Mouth Neoplasms - diagnosis</topic><topic>Mouth Neoplasms - pathology</topic><topic>Mouth Neoplasms - surgery</topic><topic>Neoplasm Recurrence, Local</topic><topic>Oral cavity</topic><topic>Otolaryngology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suzuki, Jun</creatorcontrib><creatorcontrib>Hashimoto, Sho</creatorcontrib><creatorcontrib>Watanabe, Ken-ichi</creatorcontrib><creatorcontrib>Takahashi, Kaoru</creatorcontrib><creatorcontrib>Usubuchi, Hajime</creatorcontrib><creatorcontrib>Suzuki, Hiroyoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Auris, nasus, larynx</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suzuki, Jun</au><au>Hashimoto, Sho</au><au>Watanabe, Ken-ichi</au><au>Takahashi, Kaoru</au><au>Usubuchi, Hajime</au><au>Suzuki, Hiroyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carcinoma cuniculatum mimicking leukoplakia of the mandibular gingiva</atitle><jtitle>Auris, nasus, larynx</jtitle><addtitle>Auris Nasus Larynx</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>39</volume><issue>3</issue><spage>321</spage><epage>325</epage><pages>321-325</pages><issn>0385-8146</issn><eissn>1879-1476</eissn><abstract>Abstract Carcinoma cuniculatum (CC) is a rare variant of low-grade squamous cell carcinoma (SCC), and occurrence in the oral cavity is quite unusual. CC has a papillomatous keratinized surface like verrucous carcinoma, but CC has a propensity for aggressive local invasion, especially into the bone. Therefore, CC can be quite difficult to remove surgically. A 68-year-old man presented with a case of CC mimicking verrucous leukoplakia in the mandibular gingiva. Repeated biopsies showed no malignancy. Local resection was performed, and histological examination revealed the presence of well-differentiated SCC. Additional hemi-mandibulectomy was performed and the final histological diagnosis was CC. Local recurrence was detected at the 14-month follow-up examination. Chemotherapy with docetaxel was not effective, and he died of aspiration pneumonia. CC of the oral cavity is a rare entity and the diagnosis is hard to establish. Misdiagnosis could result in inadequate removal and local recurrence. 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| subjects | Aged Carcinoma cuniculatum Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Diagnosis, Differential Humans Leukoplakia, Oral - diagnosis Leukoplakia, Oral - pathology Male Mandible Mandible - pathology Mouth Neoplasms - diagnosis Mouth Neoplasms - pathology Mouth Neoplasms - surgery Neoplasm Recurrence, Local Oral cavity Otolaryngology |
| title | Carcinoma cuniculatum mimicking leukoplakia of the mandibular gingiva |
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