Anti-diabetic activity of extract from Persea americana Mill. leaf via the activation of protein kinase B (PKB/Akt) in streptozotocin-induced diabetic rats

The leaves of Persea americana Mill. (Lauraceae) have been popularly used in the treatment of diabetes in countries in Latin America and Africa. To investigate the hypoglycaemic properties and to determine the molecular mechanism by which the hydroalcoholic extract of the leaves of Persea americana...

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Veröffentlicht in:	Journal of ethnopharmacology 2012-05, Vol.141 (1), p.517-525
Hauptverfasser:	Lima, C.R., Vasconcelos, C.F.B., Costa-Silva, J.H., Maranhão, C.A., Costa, J., Batista, T.M., Carneiro, E.M., Soares, L.A.L., Ferreira, F., Wanderley, A.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Blood Glucose - drug effects Diabetes Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - enzymology Drinking - drug effects Eating - drug effects Energy Metabolism - drug effects Enzyme Activation Enzyme Activators - administration & dosage Enzyme Activators - isolation & purification Enzyme Activators - pharmacology Ethanol - chemistry Glucose Tolerance Test Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - isolation & purification Hypoglycemic Agents - pharmacology Insulin - blood Lauraceae Liver - drug effects Liver - enzymology Male Muscle, Skeletal - drug effects Muscle, Skeletal - enzymology Persea - chemistry Persea americana Mill Phosphorylation Phytotherapy Plant Extracts - administration & dosage Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Leaves Plants, Medicinal Protein kinase B (PKB/Akt) Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Wistar Signal Transduction - drug effects Solvents - chemistry Time Factors Weight Gain - drug effects
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