Folate exacerbates the effects of ethanol on peripubertal mouse mammary gland development
Abstract Alcohol consumption is linked with increased breast cancer risk in women, even at low levels of ingestion. The proposed mechanisms whereby ethanol exerts its effects include decreased folate levels resulting in diminished DNA synthesis and repair, and/or acetaldehyde-generated DNA damage. B...
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| Veröffentlicht in: | Alcohol (Fayetteville, N.Y.) N.Y.), 2012-05, Vol.46 (3), p.285-292 |
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| creator | Masso-Welch, Patricia A Tobias, Menachem E Vasantha Kumar, Shyam C Bodziak, MaryLou Mashtare, Terry Tamburlin, Judith Koury, Stephen T |
| description | Abstract Alcohol consumption is linked with increased breast cancer risk in women, even at low levels of ingestion. The proposed mechanisms whereby ethanol exerts its effects include decreased folate levels resulting in diminished DNA synthesis and repair, and/or acetaldehyde-generated DNA damage. Based on these proposed mechanisms, we hypothesized that ethanol would have increased deleterious effects during periods of rapid mammary gland epithelial proliferation, such as peripuberty, and that folate deficiency alone might mimic and/or exacerbate the effects of ethanol. To test this hypothesis, weight-matched 28–35 day old CD2F1 female mice were pair-fed liquid diets ±3.2% ethanol, ±0.1% folate for 4 weeks. Folate status was confirmed by assay of liver and kidney tissues. In folate deficient mice, no significant ethanol-induced changes to the mammary gland were observed. Folate replete mice fed ethanol had an increased number of ducts per section, due to an increased number of terminal short branches. Serum estrogen levels were increased by ethanol, but only in folate replete mice. These results demonstrate that folate deficiency alone does not mimic the effects of ethanol, and that folate deficiency in the presence of ethanol blocks proliferative effects of ethanol on the mammary ductal tree. |
| doi_str_mv | 10.1016/j.alcohol.2011.12.003 |
| format | Article |
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The proposed mechanisms whereby ethanol exerts its effects include decreased folate levels resulting in diminished DNA synthesis and repair, and/or acetaldehyde-generated DNA damage. Based on these proposed mechanisms, we hypothesized that ethanol would have increased deleterious effects during periods of rapid mammary gland epithelial proliferation, such as peripuberty, and that folate deficiency alone might mimic and/or exacerbate the effects of ethanol. To test this hypothesis, weight-matched 28–35 day old CD2F1 female mice were pair-fed liquid diets ±3.2% ethanol, ±0.1% folate for 4 weeks. Folate status was confirmed by assay of liver and kidney tissues. In folate deficient mice, no significant ethanol-induced changes to the mammary gland were observed. Folate replete mice fed ethanol had an increased number of ducts per section, due to an increased number of terminal short branches. Serum estrogen levels were increased by ethanol, but only in folate replete mice. These results demonstrate that folate deficiency alone does not mimic the effects of ethanol, and that folate deficiency in the presence of ethanol blocks proliferative effects of ethanol on the mammary ductal tree.</description><identifier>ISSN: 0741-8329</identifier><identifier>EISSN: 1873-6823</identifier><identifier>DOI: 10.1016/j.alcohol.2011.12.003</identifier><identifier>PMID: 22440688</identifier><identifier>CODEN: ALCOEX</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Breast cancer ; Breasts ; Cell division ; Development ; Diet ; Estradiol - blood ; Ethanol ; Ethanol - pharmacology ; Female ; Folate ; Folic Acid - metabolism ; Folic Acid - pharmacology ; Folic Acid Deficiency - physiopathology ; Histology ; Hypotheses ; Mammary gland ; Mammary Glands, Animal - drug effects ; Mammary Glands, Animal - growth & development ; Medical research ; Mice ; Mouse ; Psychiatry ; Puberty ; Rodents ; Women</subject><ispartof>Alcohol (Fayetteville, N.Y.), 2012-05, Vol.46 (3), p.285-292</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-dfad61c7685634aec84b48f85fba9df622af792570e6104388ff344d57e30f7e3</citedby><cites>FETCH-LOGICAL-c448t-dfad61c7685634aec84b48f85fba9df622af792570e6104388ff344d57e30f7e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S074183291200033X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22440688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Masso-Welch, Patricia A</creatorcontrib><creatorcontrib>Tobias, Menachem E</creatorcontrib><creatorcontrib>Vasantha Kumar, Shyam C</creatorcontrib><creatorcontrib>Bodziak, MaryLou</creatorcontrib><creatorcontrib>Mashtare, Terry</creatorcontrib><creatorcontrib>Tamburlin, Judith</creatorcontrib><creatorcontrib>Koury, Stephen T</creatorcontrib><title>Folate exacerbates the effects of ethanol on peripubertal mouse mammary gland development</title><title>Alcohol (Fayetteville, N.Y.)</title><addtitle>Alcohol</addtitle><description>Abstract Alcohol consumption is linked with increased breast cancer risk in women, even at low levels of ingestion. The proposed mechanisms whereby ethanol exerts its effects include decreased folate levels resulting in diminished DNA synthesis and repair, and/or acetaldehyde-generated DNA damage. Based on these proposed mechanisms, we hypothesized that ethanol would have increased deleterious effects during periods of rapid mammary gland epithelial proliferation, such as peripuberty, and that folate deficiency alone might mimic and/or exacerbate the effects of ethanol. To test this hypothesis, weight-matched 28–35 day old CD2F1 female mice were pair-fed liquid diets ±3.2% ethanol, ±0.1% folate for 4 weeks. Folate status was confirmed by assay of liver and kidney tissues. In folate deficient mice, no significant ethanol-induced changes to the mammary gland were observed. Folate replete mice fed ethanol had an increased number of ducts per section, due to an increased number of terminal short branches. Serum estrogen levels were increased by ethanol, but only in folate replete mice. These results demonstrate that folate deficiency alone does not mimic the effects of ethanol, and that folate deficiency in the presence of ethanol blocks proliferative effects of ethanol on the mammary ductal tree.</description><subject>Animals</subject><subject>Breast cancer</subject><subject>Breasts</subject><subject>Cell division</subject><subject>Development</subject><subject>Diet</subject><subject>Estradiol - blood</subject><subject>Ethanol</subject><subject>Ethanol - pharmacology</subject><subject>Female</subject><subject>Folate</subject><subject>Folic Acid - metabolism</subject><subject>Folic Acid - pharmacology</subject><subject>Folic Acid Deficiency - physiopathology</subject><subject>Histology</subject><subject>Hypotheses</subject><subject>Mammary gland</subject><subject>Mammary Glands, Animal - drug effects</subject><subject>Mammary Glands, Animal - growth & development</subject><subject>Medical research</subject><subject>Mice</subject><subject>Mouse</subject><subject>Psychiatry</subject><subject>Puberty</subject><subject>Rodents</subject><subject>Women</subject><issn>0741-8329</issn><issn>1873-6823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkk2L1TAUhoMozp3Rn6AE3LhpzVebdKPI4IzCgAsVdBXS9MSba9rUpB2cf2_KvSrMxk0-4HlPTp4EoWeU1JTQ9tWhNsHGfQw1I5TWlNWE8AdoR5XkVasYf4h2RApaKc66M3Se84EQIqXsHqMzxoQgrVI79O0qBrMAhl_GQurLMuNlX_bOgV0yjg7DsjdTDDhOeIbk57WHtJiAx7hmwKMZR5Pu8PdgpgEPcAshziNMyxP0yJmQ4elpvkBfrt59vnxf3Xy8_nD59qayQqilGpwZWmplq5qWCwNWiV4opxrXm25wLWPGyY41kkBLieBKOceFGBoJnLgyXKCXx7pzij9XyIsefbYQSj9QOtSUENo1VAha0Bf30ENc01S6KxSTjCpOu0I1R8qmmHMCp-fktzsWSG_u9UGf3OvNvaZMF_cl9_xUfe1HGP6m_sguwJsjAEXHrYeks_UwWRh8KrL1EP1_j3h9r4INfvLWhB9wB_nfbXQuAf1p-wDb-1NGtvhX_ht26Ky-</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Masso-Welch, Patricia A</creator><creator>Tobias, Menachem E</creator><creator>Vasantha Kumar, Shyam C</creator><creator>Bodziak, MaryLou</creator><creator>Mashtare, Terry</creator><creator>Tamburlin, Judith</creator><creator>Koury, Stephen T</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QG</scope><scope>7RV</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AM</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGRYB</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K7.</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0O</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20120501</creationdate><title>Folate exacerbates the effects of ethanol on peripubertal mouse mammary gland development</title><author>Masso-Welch, Patricia A ; Tobias, Menachem E ; Vasantha Kumar, Shyam C ; Bodziak, MaryLou ; Mashtare, Terry ; Tamburlin, Judith ; Koury, Stephen T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-dfad61c7685634aec84b48f85fba9df622af792570e6104388ff344d57e30f7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Breast cancer</topic><topic>Breasts</topic><topic>Cell division</topic><topic>Development</topic><topic>Diet</topic><topic>Estradiol - blood</topic><topic>Ethanol</topic><topic>Ethanol - pharmacology</topic><topic>Female</topic><topic>Folate</topic><topic>Folic Acid - metabolism</topic><topic>Folic Acid - pharmacology</topic><topic>Folic Acid Deficiency - physiopathology</topic><topic>Histology</topic><topic>Hypotheses</topic><topic>Mammary gland</topic><topic>Mammary Glands, Animal - drug effects</topic><topic>Mammary Glands, Animal - growth & development</topic><topic>Medical research</topic><topic>Mice</topic><topic>Mouse</topic><topic>Psychiatry</topic><topic>Puberty</topic><topic>Rodents</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Masso-Welch, Patricia A</creatorcontrib><creatorcontrib>Tobias, Menachem E</creatorcontrib><creatorcontrib>Vasantha Kumar, Shyam C</creatorcontrib><creatorcontrib>Bodziak, MaryLou</creatorcontrib><creatorcontrib>Mashtare, Terry</creatorcontrib><creatorcontrib>Tamburlin, Judith</creatorcontrib><creatorcontrib>Koury, Stephen T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Criminal Justice Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Criminology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>ProQuest Criminal Justice</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Alcohol (Fayetteville, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Masso-Welch, Patricia A</au><au>Tobias, Menachem E</au><au>Vasantha Kumar, Shyam C</au><au>Bodziak, MaryLou</au><au>Mashtare, Terry</au><au>Tamburlin, Judith</au><au>Koury, Stephen T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Folate exacerbates the effects of ethanol on peripubertal mouse mammary gland development</atitle><jtitle>Alcohol (Fayetteville, N.Y.)</jtitle><addtitle>Alcohol</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>46</volume><issue>3</issue><spage>285</spage><epage>292</epage><pages>285-292</pages><issn>0741-8329</issn><eissn>1873-6823</eissn><coden>ALCOEX</coden><abstract>Abstract Alcohol consumption is linked with increased breast cancer risk in women, even at low levels of ingestion. The proposed mechanisms whereby ethanol exerts its effects include decreased folate levels resulting in diminished DNA synthesis and repair, and/or acetaldehyde-generated DNA damage. Based on these proposed mechanisms, we hypothesized that ethanol would have increased deleterious effects during periods of rapid mammary gland epithelial proliferation, such as peripuberty, and that folate deficiency alone might mimic and/or exacerbate the effects of ethanol. To test this hypothesis, weight-matched 28–35 day old CD2F1 female mice were pair-fed liquid diets ±3.2% ethanol, ±0.1% folate for 4 weeks. Folate status was confirmed by assay of liver and kidney tissues. In folate deficient mice, no significant ethanol-induced changes to the mammary gland were observed. Folate replete mice fed ethanol had an increased number of ducts per section, due to an increased number of terminal short branches. Serum estrogen levels were increased by ethanol, but only in folate replete mice. These results demonstrate that folate deficiency alone does not mimic the effects of ethanol, and that folate deficiency in the presence of ethanol blocks proliferative effects of ethanol on the mammary ductal tree.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>22440688</pmid><doi>10.1016/j.alcohol.2011.12.003</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Breast cancer Breasts Cell division Development Diet Estradiol - blood Ethanol Ethanol - pharmacology Female Folate Folic Acid - metabolism Folic Acid - pharmacology Folic Acid Deficiency - physiopathology Histology Hypotheses Mammary gland Mammary Glands, Animal - drug effects Mammary Glands, Animal - growth & development Medical research Mice Mouse Psychiatry Puberty Rodents Women |
| title | Folate exacerbates the effects of ethanol on peripubertal mouse mammary gland development |
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