Alterations of plasma aspartic acid, glycine and asparagine levels in patients with major depressive disorder
To evaluate the changes of plasma levels of the excitatory amino acid neurotransmitter aspartic acid (Asp), inhibitory neurotransmitter glycine (Gly) and asparagine (Asn) in patients with major depressive disorder (MDD). Plasma samples were collected from 15 MDD patients (9 males and 6 females, aged...
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| Veröffentlicht in: | Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban 2012-03, Vol.41 (2), p.132-138 |
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| container_title | Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban |
| container_volume | 41 |
| creator | Fu, Xin-yan Lu, Yun-rong Wu, Juan-li Wu, Xue-yan Bao, Ai-min |
| description | To evaluate the changes of plasma levels of the excitatory amino acid neurotransmitter aspartic acid (Asp), inhibitory neurotransmitter glycine (Gly) and asparagine (Asn) in patients with major depressive disorder (MDD).
Plasma samples were collected from 15 MDD patients (9 males and 6 females, aged 32-64 y) and 14 healthy subjects (7 males and 7 females, aged 30-65 y); and also collected from 7 MDD patients (5 males and 2 females) 2 months after antidepressant treatment. The plasma levels of amino acids were determined by high performance liquid chromatography with fluorescence detection method.
Plasma Asp and Gly levels were significantly lower in MDD patients than those in controls (P |
| format | Article |
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Plasma samples were collected from 15 MDD patients (9 males and 6 females, aged 32-64 y) and 14 healthy subjects (7 males and 7 females, aged 30-65 y); and also collected from 7 MDD patients (5 males and 2 females) 2 months after antidepressant treatment. The plasma levels of amino acids were determined by high performance liquid chromatography with fluorescence detection method.
Plasma Asp and Gly levels were significantly lower in MDD patients than those in controls (P<0.04). There were positive correlations between plasma levels of Gly and Asp, and between Gly and Asn (P<0.005) in the control group; while in MDD patients, a significant positive correlation was found only between plasma levels of Gly and of Asp (P<0.001). MDD patients did not show significant changes in plasma Asp, Asn and</description><identifier>ISSN: 1008-9292</identifier><identifier>PMID: 22499508</identifier><language>chi</language><publisher>China</publisher><subject>Adult ; Aged ; Antidepressive Agents - therapeutic use ; Asparagine - blood ; Aspartic Acid - blood ; Depressive Disorder, Major - blood ; Depressive Disorder, Major - drug therapy ; Female ; Glycine - blood ; Humans ; Male ; Middle Aged</subject><ispartof>Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban, 2012-03, Vol.41 (2), p.132-138</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22499508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fu, Xin-yan</creatorcontrib><creatorcontrib>Lu, Yun-rong</creatorcontrib><creatorcontrib>Wu, Juan-li</creatorcontrib><creatorcontrib>Wu, Xue-yan</creatorcontrib><creatorcontrib>Bao, Ai-min</creatorcontrib><title>Alterations of plasma aspartic acid, glycine and asparagine levels in patients with major depressive disorder</title><title>Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban</title><addtitle>Zhejiang Da Xue Xue Bao Yi Xue Ban</addtitle><description>To evaluate the changes of plasma levels of the excitatory amino acid neurotransmitter aspartic acid (Asp), inhibitory neurotransmitter glycine (Gly) and asparagine (Asn) in patients with major depressive disorder (MDD).
Plasma samples were collected from 15 MDD patients (9 males and 6 females, aged 32-64 y) and 14 healthy subjects (7 males and 7 females, aged 30-65 y); and also collected from 7 MDD patients (5 males and 2 females) 2 months after antidepressant treatment. The plasma levels of amino acids were determined by high performance liquid chromatography with fluorescence detection method.
Plasma Asp and Gly levels were significantly lower in MDD patients than those in controls (P<0.04). There were positive correlations between plasma levels of Gly and Asp, and between Gly and Asn (P<0.005) in the control group; while in MDD patients, a significant positive correlation was found only between plasma levels of Gly and of Asp (P<0.001). MDD patients did not show significant changes in plasma Asp, Asn and</description><subject>Adult</subject><subject>Aged</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Asparagine - blood</subject><subject>Aspartic Acid - blood</subject><subject>Depressive Disorder, Major - blood</subject><subject>Depressive Disorder, Major - drug therapy</subject><subject>Female</subject><subject>Glycine - blood</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><issn>1008-9292</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UMlqwzAU1KGlCWl-oejYQw1avMjHELpBoJf2bJ79nlMV2VYlJSV_X5ekzGEYZpiBuWJLKYTJalWrBVvHaFtRSF3NEDdsoVRe14UwSzZsXKIAyU5j5FPPvYM4AIfoISTbcegsPvC9O3V2JA4jni3Y_0lHR3KR25H7uYHGFPmPTZ98gK8pcCQfaF4-Ekcbp4AUbtl1Dy7S-sIr9vH0-L59yXZvz6_bzS7zUpUpAwJZYSlzJNSqq4yEWupOVoXJewmyR5S5KnshW9S1aMseirJoEVsgY7TQK3Z_7vVh-j5QTM1gY0fOwUjTITbzNyIXRhTVHL27RA_tQNj4YAcIp-b_Iv0Ld-9kaw</recordid><startdate>201203</startdate><enddate>201203</enddate><creator>Fu, Xin-yan</creator><creator>Lu, Yun-rong</creator><creator>Wu, Juan-li</creator><creator>Wu, Xue-yan</creator><creator>Bao, Ai-min</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201203</creationdate><title>Alterations of plasma aspartic acid, glycine and asparagine levels in patients with major depressive disorder</title><author>Fu, Xin-yan ; Lu, Yun-rong ; Wu, Juan-li ; Wu, Xue-yan ; Bao, Ai-min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-aea17d614ded32c781a913c17584f1a1fdd1426f01bd390b6fa565bddbae88303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Asparagine - blood</topic><topic>Aspartic Acid - blood</topic><topic>Depressive Disorder, Major - blood</topic><topic>Depressive Disorder, Major - drug therapy</topic><topic>Female</topic><topic>Glycine - blood</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><toplevel>online_resources</toplevel><creatorcontrib>Fu, Xin-yan</creatorcontrib><creatorcontrib>Lu, Yun-rong</creatorcontrib><creatorcontrib>Wu, Juan-li</creatorcontrib><creatorcontrib>Wu, Xue-yan</creatorcontrib><creatorcontrib>Bao, Ai-min</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fu, Xin-yan</au><au>Lu, Yun-rong</au><au>Wu, Juan-li</au><au>Wu, Xue-yan</au><au>Bao, Ai-min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alterations of plasma aspartic acid, glycine and asparagine levels in patients with major depressive disorder</atitle><jtitle>Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban</jtitle><addtitle>Zhejiang Da Xue Xue Bao Yi Xue Ban</addtitle><date>2012-03</date><risdate>2012</risdate><volume>41</volume><issue>2</issue><spage>132</spage><epage>138</epage><pages>132-138</pages><issn>1008-9292</issn><abstract>To evaluate the changes of plasma levels of the excitatory amino acid neurotransmitter aspartic acid (Asp), inhibitory neurotransmitter glycine (Gly) and asparagine (Asn) in patients with major depressive disorder (MDD).
Plasma samples were collected from 15 MDD patients (9 males and 6 females, aged 32-64 y) and 14 healthy subjects (7 males and 7 females, aged 30-65 y); and also collected from 7 MDD patients (5 males and 2 females) 2 months after antidepressant treatment. The plasma levels of amino acids were determined by high performance liquid chromatography with fluorescence detection method.
Plasma Asp and Gly levels were significantly lower in MDD patients than those in controls (P<0.04). There were positive correlations between plasma levels of Gly and Asp, and between Gly and Asn (P<0.005) in the control group; while in MDD patients, a significant positive correlation was found only between plasma levels of Gly and of Asp (P<0.001). MDD patients did not show significant changes in plasma Asp, Asn and</abstract><cop>China</cop><pmid>22499508</pmid><tpages>7</tpages></addata></record> |
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| ispartof | Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban, 2012-03, Vol.41 (2), p.132-138 |
| issn | 1008-9292 |
| language | chi |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Antidepressive Agents - therapeutic use Asparagine - blood Aspartic Acid - blood Depressive Disorder, Major - blood Depressive Disorder, Major - drug therapy Female Glycine - blood Humans Male Middle Aged |
| title | Alterations of plasma aspartic acid, glycine and asparagine levels in patients with major depressive disorder |
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