Nutraceutical-mediated restoration of wild-type levels of IKBKAP-encoded IKAP protein in familial dysautonomia-derived cells

Scope The reported ability to modulate the production of the wild‐type transcript in cells bearing the splice‐altering familial dysautonomia (FD)‐causing mutation in the IKBKAP gene prompted an evaluation of the impact of commonly consumed nutraceuticals on the splicing of this transcript. Methods a...

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Veröffentlicht in:	Molecular nutrition & food research 2012-04, Vol.56 (4), p.570-579
Hauptverfasser:	Anderson, Sylvia L., Liu, Bo, Qiu, Jinsong, Sturm, Andrea J., Schwartz, Jamie A., Peters, Austin J., Sullivan, Kerry A., Rubin, Berish Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Biological and medical sciences Blotting, Western Carrier Proteins - genetics Carrier Proteins - metabolism Catechin - analogs & derivatives Catechin - pharmacology Dietary Supplements Drug Synergism Dysautonomia, Familial - genetics Dysautonomia, Familial - metabolism Familial dysautonomia Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Food industries Fundamental and applied biological sciences. Psychology Genistein Genistein - pharmacology Genotype HEK293 Cells Humans Isoflavone Isoflavones - pharmacology Neurons - cytology Neurons - drug effects Neurons - metabolism Nutraceutical Phosphotransferases (Phosphate Group Acceptor) - genetics Phosphotransferases (Phosphate Group Acceptor) - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA Splicing - drug effects Up-Regulation
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