Relationship of HLA-DRB1 Alleles With Hepatocellular Carcinoma Development in Chronic Hepatitis B Patients
GOALS:We intended to analyze the relationship between specific human leukocyte antigen (HLA)-DRB1 alleles and development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients. STUDY:A database of 468 consecutive CHB patients who received lamivudine for more than 12 months between...
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| Veröffentlicht in: | Journal of clinical gastroenterology 2012-05, Vol.46 (5), p.420-426 |
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| creator | Jin, Young-Joo Shim, Ju Hyun Chung, Young-Hwa Kim, Jeong A Gi Choi, Jong Park, Won Hyung Lee, Danbi Seon Lee, Yoon Kim, Sung Eun Kim, Sung Hoon Yang, Soo Hyun |
| description | GOALS:We intended to analyze the relationship between specific human leukocyte antigen (HLA)-DRB1 alleles and development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients.
STUDY:A database of 468 consecutive CHB patients who received lamivudine for more than 12 months between July 1996 and February 2011 was retrospectively analyzed. Sera and buffy coats samples were obtained between April 2008 and April 2010. Six-digit HLA-DRB1 genotyping was performed with sequence-based typing. Serum α fetoprotein levels and ultrasonography or computed tomography image studies were assessed every 3 to 6 months for surveillance of HCC.
RESULTS:At baseline, median age was 43 years (range, 16 to 71) [male359 (76.7%); HBeAg positivity385 (82.3%)]. Among the 27 HLA-DRB1 alleles identified, HLA-DRB1*090102, *080302, and *070101 were the most frequent (>10%). HCC was diagnosed in 36 (7.7%) patients during the median follow-up of 69 months. The frequency of the HLA-DRB1*140101 allele was 9.0% and significantly higher in patients of the HCC group than those of the non-HCC group (19.4 vs. 8.1%, P=0.014). The 2-year, 4-year, and 6-year cumulative rates of HCC development were markedly higher in patients with HLA-DRB1*140101 than those without HLA-DRB1*140101 (2.4, 8.2, and 25.1% vs. 1.9, 4.7, and 7.4%, respectively, P=0.011). No other HLA-DRB1 alleles were associated with HCC development. Baseline clinical characteristics did not differ between patients with and without HLA-DRB1*140101.
CONCLUSIONS:The HLA-DRB1*140101 allele may be potentially associated with increased risk of HCC development in CHB patients, irrespective of the replicative activity of hepatitis B virus and antiviral responsiveness. |
| doi_str_mv | 10.1097/MCG.0b013e318239f9cc |
| format | Article |
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STUDY:A database of 468 consecutive CHB patients who received lamivudine for more than 12 months between July 1996 and February 2011 was retrospectively analyzed. Sera and buffy coats samples were obtained between April 2008 and April 2010. Six-digit HLA-DRB1 genotyping was performed with sequence-based typing. Serum α fetoprotein levels and ultrasonography or computed tomography image studies were assessed every 3 to 6 months for surveillance of HCC.
RESULTS:At baseline, median age was 43 years (range, 16 to 71) [male359 (76.7%); HBeAg positivity385 (82.3%)]. Among the 27 HLA-DRB1 alleles identified, HLA-DRB1*090102, *080302, and *070101 were the most frequent (>10%). HCC was diagnosed in 36 (7.7%) patients during the median follow-up of 69 months. The frequency of the HLA-DRB1*140101 allele was 9.0% and significantly higher in patients of the HCC group than those of the non-HCC group (19.4 vs. 8.1%, P=0.014). The 2-year, 4-year, and 6-year cumulative rates of HCC development were markedly higher in patients with HLA-DRB1*140101 than those without HLA-DRB1*140101 (2.4, 8.2, and 25.1% vs. 1.9, 4.7, and 7.4%, respectively, P=0.011). No other HLA-DRB1 alleles were associated with HCC development. Baseline clinical characteristics did not differ between patients with and without HLA-DRB1*140101.
CONCLUSIONS:The HLA-DRB1*140101 allele may be potentially associated with increased risk of HCC development in CHB patients, irrespective of the replicative activity of hepatitis B virus and antiviral responsiveness.</description><identifier>ISSN: 0192-0790</identifier><identifier>EISSN: 1539-2031</identifier><identifier>DOI: 10.1097/MCG.0b013e318239f9cc</identifier><identifier>PMID: 22499074</identifier><identifier>CODEN: JCGADC</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Alleles ; Biological and medical sciences ; Carcinoma, Hepatocellular - genetics ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Hepatitis B, Chronic - genetics ; HLA-DRB1 Chains - genetics ; Human viral diseases ; Humans ; Infectious diseases ; Liver Neoplasms - genetics ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Tumors ; Viral diseases ; Viral hepatitis ; Young Adult</subject><ispartof>Journal of clinical gastroenterology, 2012-05, Vol.46 (5), p.420-426</ispartof><rights>2012 Lippincott Williams & Wilkins, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3825-e346708d56ebe08154692c754ee598fd537c18903cb454fcddf058a30ab169123</citedby><cites>FETCH-LOGICAL-c3825-e346708d56ebe08154692c754ee598fd537c18903cb454fcddf058a30ab169123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25835527$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22499074$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jin, Young-Joo</creatorcontrib><creatorcontrib>Shim, Ju Hyun</creatorcontrib><creatorcontrib>Chung, Young-Hwa</creatorcontrib><creatorcontrib>Kim, Jeong A</creatorcontrib><creatorcontrib>Gi Choi, Jong</creatorcontrib><creatorcontrib>Park, Won Hyung</creatorcontrib><creatorcontrib>Lee, Danbi</creatorcontrib><creatorcontrib>Seon Lee, Yoon</creatorcontrib><creatorcontrib>Kim, Sung Eun</creatorcontrib><creatorcontrib>Kim, Sung Hoon</creatorcontrib><creatorcontrib>Yang, Soo Hyun</creatorcontrib><title>Relationship of HLA-DRB1 Alleles With Hepatocellular Carcinoma Development in Chronic Hepatitis B Patients</title><title>Journal of clinical gastroenterology</title><addtitle>J Clin Gastroenterol</addtitle><description>GOALS:We intended to analyze the relationship between specific human leukocyte antigen (HLA)-DRB1 alleles and development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients.
STUDY:A database of 468 consecutive CHB patients who received lamivudine for more than 12 months between July 1996 and February 2011 was retrospectively analyzed. Sera and buffy coats samples were obtained between April 2008 and April 2010. Six-digit HLA-DRB1 genotyping was performed with sequence-based typing. Serum α fetoprotein levels and ultrasonography or computed tomography image studies were assessed every 3 to 6 months for surveillance of HCC.
RESULTS:At baseline, median age was 43 years (range, 16 to 71) [male359 (76.7%); HBeAg positivity385 (82.3%)]. Among the 27 HLA-DRB1 alleles identified, HLA-DRB1*090102, *080302, and *070101 were the most frequent (>10%). HCC was diagnosed in 36 (7.7%) patients during the median follow-up of 69 months. The frequency of the HLA-DRB1*140101 allele was 9.0% and significantly higher in patients of the HCC group than those of the non-HCC group (19.4 vs. 8.1%, P=0.014). The 2-year, 4-year, and 6-year cumulative rates of HCC development were markedly higher in patients with HLA-DRB1*140101 than those without HLA-DRB1*140101 (2.4, 8.2, and 25.1% vs. 1.9, 4.7, and 7.4%, respectively, P=0.011). No other HLA-DRB1 alleles were associated with HCC development. Baseline clinical characteristics did not differ between patients with and without HLA-DRB1*140101.
CONCLUSIONS:The HLA-DRB1*140101 allele may be potentially associated with increased risk of HCC development in CHB patients, irrespective of the replicative activity of hepatitis B virus and antiviral responsiveness.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Hepatitis B, Chronic - genetics</subject><subject>HLA-DRB1 Chains - genetics</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Tumors</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>Young Adult</subject><issn>0192-0790</issn><issn>1539-2031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1v1DAQhi0EokvhHyDkC1Ivacd2nMTHbQpdpEWgCsQxcpyJ4uLEwU6o-Pd4tQuVehjNjOaZD71DyFsGlwxUefW5vr2EFphAwSouVK-MeUY2TAqVcRDsOdkAUzyDUsEZeRXjPQArhWAvyRnnuVJQ5htyf4dOL9ZPcbAz9T3d7bfZzd01o1vn0GGkP-wy0B3OevEGnVudDrTWwdjJj5re4G90fh5xWqidaD0EP1lz5O1iI72mX1OUyvE1edFrF_HNyZ-T7x8_fKt32f7L7ad6u8-MqLjMUORFCVUnC2wRKibzQnFTyhxRqqrvpCgNqxQI0-Yy703X9SArLUC3rFCMi3NycZw7B_9rxbg0o42H0_WEfo0NA4AcpJQiofkRNcHHGLBv5mBHHf4kqDmo3CSVm6cqp7Z3pw1rO2L3v-mfrAl4fwJ0NNr1QU_GxkdOVkJKXj7uf_BuwRB_uvUBQzOgdsvQwOHQShTpnYyDTFmWLD34LzjdlOM</recordid><startdate>201205</startdate><enddate>201205</enddate><creator>Jin, Young-Joo</creator><creator>Shim, Ju Hyun</creator><creator>Chung, Young-Hwa</creator><creator>Kim, Jeong A</creator><creator>Gi Choi, Jong</creator><creator>Park, Won Hyung</creator><creator>Lee, Danbi</creator><creator>Seon Lee, Yoon</creator><creator>Kim, Sung Eun</creator><creator>Kim, Sung Hoon</creator><creator>Yang, Soo Hyun</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201205</creationdate><title>Relationship of HLA-DRB1 Alleles With Hepatocellular Carcinoma Development in Chronic Hepatitis B Patients</title><author>Jin, Young-Joo ; Shim, Ju Hyun ; Chung, Young-Hwa ; Kim, Jeong A ; Gi Choi, Jong ; Park, Won Hyung ; Lee, Danbi ; Seon Lee, Yoon ; Kim, Sung Eun ; Kim, Sung Hoon ; Yang, Soo Hyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3825-e346708d56ebe08154692c754ee598fd537c18903cb454fcddf058a30ab169123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Hepatitis B, Chronic - genetics</topic><topic>HLA-DRB1 Chains - genetics</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Tumors</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jin, Young-Joo</creatorcontrib><creatorcontrib>Shim, Ju Hyun</creatorcontrib><creatorcontrib>Chung, Young-Hwa</creatorcontrib><creatorcontrib>Kim, Jeong A</creatorcontrib><creatorcontrib>Gi Choi, Jong</creatorcontrib><creatorcontrib>Park, Won Hyung</creatorcontrib><creatorcontrib>Lee, Danbi</creatorcontrib><creatorcontrib>Seon Lee, Yoon</creatorcontrib><creatorcontrib>Kim, Sung Eun</creatorcontrib><creatorcontrib>Kim, Sung Hoon</creatorcontrib><creatorcontrib>Yang, Soo Hyun</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jin, Young-Joo</au><au>Shim, Ju Hyun</au><au>Chung, Young-Hwa</au><au>Kim, Jeong A</au><au>Gi Choi, Jong</au><au>Park, Won Hyung</au><au>Lee, Danbi</au><au>Seon Lee, Yoon</au><au>Kim, Sung Eun</au><au>Kim, Sung Hoon</au><au>Yang, Soo Hyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of HLA-DRB1 Alleles With Hepatocellular Carcinoma Development in Chronic Hepatitis B Patients</atitle><jtitle>Journal of clinical gastroenterology</jtitle><addtitle>J Clin Gastroenterol</addtitle><date>2012-05</date><risdate>2012</risdate><volume>46</volume><issue>5</issue><spage>420</spage><epage>426</epage><pages>420-426</pages><issn>0192-0790</issn><eissn>1539-2031</eissn><coden>JCGADC</coden><abstract>GOALS:We intended to analyze the relationship between specific human leukocyte antigen (HLA)-DRB1 alleles and development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients.
STUDY:A database of 468 consecutive CHB patients who received lamivudine for more than 12 months between July 1996 and February 2011 was retrospectively analyzed. Sera and buffy coats samples were obtained between April 2008 and April 2010. Six-digit HLA-DRB1 genotyping was performed with sequence-based typing. Serum α fetoprotein levels and ultrasonography or computed tomography image studies were assessed every 3 to 6 months for surveillance of HCC.
RESULTS:At baseline, median age was 43 years (range, 16 to 71) [male359 (76.7%); HBeAg positivity385 (82.3%)]. Among the 27 HLA-DRB1 alleles identified, HLA-DRB1*090102, *080302, and *070101 were the most frequent (>10%). HCC was diagnosed in 36 (7.7%) patients during the median follow-up of 69 months. The frequency of the HLA-DRB1*140101 allele was 9.0% and significantly higher in patients of the HCC group than those of the non-HCC group (19.4 vs. 8.1%, P=0.014). The 2-year, 4-year, and 6-year cumulative rates of HCC development were markedly higher in patients with HLA-DRB1*140101 than those without HLA-DRB1*140101 (2.4, 8.2, and 25.1% vs. 1.9, 4.7, and 7.4%, respectively, P=0.011). No other HLA-DRB1 alleles were associated with HCC development. Baseline clinical characteristics did not differ between patients with and without HLA-DRB1*140101.
CONCLUSIONS:The HLA-DRB1*140101 allele may be potentially associated with increased risk of HCC development in CHB patients, irrespective of the replicative activity of hepatitis B virus and antiviral responsiveness.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>22499074</pmid><doi>10.1097/MCG.0b013e318239f9cc</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Alleles Biological and medical sciences Carcinoma, Hepatocellular - genetics Female Gastroenterology. Liver. Pancreas. Abdomen Gene Frequency Genetic Predisposition to Disease Genotype Hepatitis B, Chronic - genetics HLA-DRB1 Chains - genetics Human viral diseases Humans Infectious diseases Liver Neoplasms - genetics Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Tumors Viral diseases Viral hepatitis Young Adult |
| title | Relationship of HLA-DRB1 Alleles With Hepatocellular Carcinoma Development in Chronic Hepatitis B Patients |
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