First-in-Class, Dual-Action, 3,5-Disubstituted Indole Derivatives Having Human Nitric Oxide Synthase (nNOS) and Norepinephrine Reuptake Inhibitory (NERI) Activity for the Treatment of Neuropathic Pain

A family of different 3,5-disubstituted indole derivatives having 6-membered rings were designed, synthesized, and demonstrated inhibition of human nitric oxide synthase (NOS) with norepinephrine reuptake inhibitory activity (NERI). The structure–activity relationship (SAR) within the cyclohexane ri...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 2012-04, Vol.55 (7), p.3488-3501
Hauptverfasser:	Mladenova, Gabriela, Annedi, Subhash C, Ramnauth, Jailall, Maddaford, Shawn P, Rakhit, Suman, Andrews, John S, Zhang, Dongqin, Porreca, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Uptake Inhibitors - chemical synthesis Adrenergic Uptake Inhibitors - chemistry Adrenergic Uptake Inhibitors - pharmacology Analgesics - chemical synthesis Analgesics - chemistry Analgesics - pharmacology Animals CHO Cells Coronary Vessels - drug effects Coronary Vessels - physiology Cricetinae Cricetulus Cyclohexanes - chemical synthesis Cyclohexanes - chemistry Cyclohexanes - pharmacology ERG1 Potassium Channel Ether-A-Go-Go Potassium Channels - antagonists & inhibitors HEK293 Cells High-Throughput Screening Assays Humans In Vitro Techniques Indoles - chemical synthesis Indoles - chemistry Indoles - pharmacology Muscle Contraction Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Neuralgia - drug therapy Nitric Oxide Synthase Type I - antagonists & inhibitors Norepinephrine Plasma Membrane Transport Proteins - metabolism Rats Stereoisomerism Structure-Activity Relationship Thiophenes - chemical synthesis Thiophenes - chemistry Thiophenes - pharmacology Vascular Resistance
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!