Erythropoietin, but not the correction of anemia alone, protects from chronic kidney allograft injury

Anemia can contribute to chronic allograft injury by limiting oxygen delivery to tissues, particularly in the tubulointerstitium. To determine mechanisms by which erythropoietin (EPO) prevents chronic allograft injury we utilized a rat model of full MHC-mismatched kidney transplantation (Wistar Furt...

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Veröffentlicht in:	Kidney international 2012-05, Vol.81 (9), p.903-918
Hauptverfasser:	Cassis, Paola, Gallon, Lorenzo, Benigni, Ariela, Mister, Marilena, Pezzotta, Anna, Solini, Samantha, Gagliardini, Elena, Cugini, Daniela, Abbate, Mauro, Aiello, Sistiana, Rocchetta, Federica, Scudeletti, Pierangela, Perico, Norberto, Noris, Marina, Remuzzi, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	anemia Anemia - blood Anemia - drug therapy Anemia - etiology Anemias. Hemoglobinopathies Animals Apoptosis - drug effects Biological and medical sciences Biomarkers - blood Blood Transfusion chronic allograft rejection Chronic Disease Diseases of red blood cells erythropoietin Erythropoietin - pharmacology Glomerulonephritis - immunology Glomerulonephritis - prevention & control Hematinics - pharmacology Hematologic and hematopoietic diseases Hemoglobins - metabolism Histocompatibility Kidney - drug effects Kidney - immunology Kidney - metabolism Kidney - pathology Kidney Diseases - immunology Kidney Diseases - metabolism Kidney Diseases - pathology Kidney Diseases - prevention & control Kidney Transplantation - adverse effects Kidney Transplantation - immunology Medical sciences Mice Nephrology. Urinary tract diseases Primary Graft Dysfunction - immunology Primary Graft Dysfunction - prevention & control Proteinuria - immunology Proteinuria - prevention & control Rats Rats, Inbred Lew Rats, Inbred WF Time Factors transplantation
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