Sildenafil attenuates TNBS-induced colitis in rats: possible involvement of cGMP and KATP channels

The involvement of cGMP/KATP pathway in effects of sildenafil on experimental colitis was investigated. Sildenafil significantly attenuated colonic injury markers. These effects were reversed by the addition of glibenclamide or ODQ, indicating the involvement of ATP‐sensitive potassium channels (KAT...

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Veröffentlicht in:	Fundamental & clinical pharmacology 2012-04, Vol.26 (2), p.190-193
Hauptverfasser:	Fakhfouri, Gohar, Rahimian, Reza, Hashemi, Saeed, Rasouli, Mohammad Reza, Bahremand, Arash, Mehr, Shahram Ejtemaei, Khorramizadeh, Mohammad Reza, Dehpour, Ahmad Reza
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences cGMP colitis Colitis - drug therapy Colitis - physiopathology Cyclic GMP - metabolism Disease Models, Animal Glyburide - pharmacology KATP KATP Channels - metabolism Male Medical sciences Pharmacology. Drug treatments Phosphodiesterase 5 Inhibitors - pharmacology Piperazines - pharmacology Purines - pharmacology Rats Rats, Sprague-Dawley sildenafil Sildenafil Citrate Sulfones - pharmacology Trinitrobenzenesulfonic Acid - toxicity
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