Effect of l-NAME, an inhibitor of nitric oxide synthesis, on plasma levels of IL-6, IL-8, TNF[alpha] and nitrite/nitrate in human septic shock
Objectives: We tested the effects of N^sup G^-nitro-L-arginine methyl ester (l-NAME), an inhibitor of nitric oxide (NO) synthesis, on plasma levels of interleukin (IL) IL-6, IL-8, tumor necrosis factor-alpha (TNFα) and nitrite/nitrate (NO^sub 2^^sup -^/NO^sub 3^^sup -^) in patients with severe septi...
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| Veröffentlicht in: | Intensive care medicine 1998-07, Vol.24 (7), p.673 |
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| container_title | Intensive care medicine |
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| creator | Avontuur, J A M Stam, T C Eggermont, A M M Braining, H A Jongen-lavrencic, M van Amsterdam, J G C |
| description | Objectives: We tested the effects of N^sup G^-nitro-L-arginine methyl ester (l-NAME), an inhibitor of nitric oxide (NO) synthesis, on plasma levels of interleukin (IL) IL-6, IL-8, tumor necrosis factor-alpha (TNFα) and nitrite/nitrate (NO^sub 2^^sup -^/NO^sub 3^^sup -^) in patients with severe septic shock. Design: Prospective clinical study. Setting: Surgical intensive care unit at a university hospital. Patients: 11 consecutive patients with severe septic shock. Interventions: Standard hemodynamic measurements were made and blood samples taken at intervals before, during, and after a 12-h infusion of l-NAME 1 mg · kg^sup -1^ ·h^sup -1^ for determination of plasma IL-6, IL-8, TNFα and NO^sub 2^^sup -^/NO^sub 3^^sup -^ concentration. Measurements and results: Patients with sepsis had increased plasma levels of IL-6, IL-8, TNFα, and NO^sub 2^^sup -^/NO^sub 3^^sup -^ (p |
| doi_str_mv | 10.1007/s001340050643 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_995591152</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2632908601</sourcerecordid><originalsourceid>FETCH-proquest_journals_9955911523</originalsourceid><addsrcrecordid>eNqNjUFOwzAQRS0EEqGwZD9iHVM7dtJmiVAqkKCr7ipUmdSRXVw7ZBwEl-DMOIIDsJkvzX96n5Brzm45Y4s5MsaFZKxklRQnJONSFJQXYnlKMiZkQWUli3NygXhI5KIqeUa-m67TbYTQgaPru-cmB-XBemNfbQzD9Pc2DraF8Gn3GvDLR6PRYg7BQ-8UHhU4_aEdTuzjE63y6S5z2KxXW-V6o16Scv-riXo-pYo6bYAZj2kMdR-TH01o3y7JWacc6qu_nJGbVbO5f6D9EN5HjXF3COPgU7Wr67KsOS8L8S_oB2PBWAk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>995591152</pqid></control><display><type>article</type><title>Effect of l-NAME, an inhibitor of nitric oxide synthesis, on plasma levels of IL-6, IL-8, TNF[alpha] and nitrite/nitrate in human septic shock</title><source>SpringerNature Journals</source><creator>Avontuur, J A; M ; Stam, T C ; Eggermont, A M; M ; Braining, H A ; Jongen-lavrencic, M ; van Amsterdam, J G; C</creator><creatorcontrib>Avontuur, J A; M ; Stam, T C ; Eggermont, A M; M ; Braining, H A ; Jongen-lavrencic, M ; van Amsterdam, J G; C</creatorcontrib><description>Objectives: We tested the effects of N^sup G^-nitro-L-arginine methyl ester (l-NAME), an inhibitor of nitric oxide (NO) synthesis, on plasma levels of interleukin (IL) IL-6, IL-8, tumor necrosis factor-alpha (TNFα) and nitrite/nitrate (NO^sub 2^^sup -^/NO^sub 3^^sup -^) in patients with severe septic shock. Design: Prospective clinical study. Setting: Surgical intensive care unit at a university hospital. Patients: 11 consecutive patients with severe septic shock. Interventions: Standard hemodynamic measurements were made and blood samples taken at intervals before, during, and after a 12-h infusion of l-NAME 1 mg · kg^sup -1^ ·h^sup -1^ for determination of plasma IL-6, IL-8, TNFα and NO^sub 2^^sup -^/NO^sub 3^^sup -^ concentration. Measurements and results: Patients with sepsis had increased plasma levels of IL-6, IL-8, TNFα, and NO^sub 2^^sup -^/NO^sub 3^^sup -^ (p<0.05). Plasma levels of IL-6, IL-8, and NO^sub 2^^sup -^/NO^sub 3^^sup -^ were negatively correlated with systemic vascular resistance (r=-0.62, r=-0.65, and r=-0.78, respectively, all p<0.05). Continuous infusion of l-NAME increased mean arterial pressure and systemic vascular resistance, with a concomitant reduction in cardiac output (all p<0.01). No significant changes were seen in levels of plasma IL-6, IL-8, and NO^sub 2^^sup -^/NO^sub 3^^sup -^ during the 24-h observation period. Plasma levels of TNFα were significantly reduced during l-NAME infusion compared to baseline (p<0.05). Conclusions: NO plays a role in the cardiovascular derangements of human septic shock. Inhibition of NO synthesis with l-NAME does not promote excessive cytokine release in patients with severe sepsis.[PUBLICATION ABSTRACT]</description><identifier>ISSN: 0342-4642</identifier><identifier>EISSN: 1432-1238</identifier><identifier>DOI: 10.1007/s001340050643</identifier><language>eng</language><publisher>Heidelberg: Springer Nature B.V</publisher><subject>Angina pectoris ; Blood pressure ; Cytokines ; Endothelium ; Hemodynamics ; Hospitals ; Hypotension ; Intensive care ; Nitrates ; Nitric oxide ; Plasma ; Pulmonary arteries ; Sepsis ; Surgery ; Tumor necrosis factor-TNF ; Veins & arteries ; Ventilators</subject><ispartof>Intensive care medicine, 1998-07, Vol.24 (7), p.673</ispartof><rights>Springer-Verlag 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Avontuur, J A; M</creatorcontrib><creatorcontrib>Stam, T C</creatorcontrib><creatorcontrib>Eggermont, A M; M</creatorcontrib><creatorcontrib>Braining, H A</creatorcontrib><creatorcontrib>Jongen-lavrencic, M</creatorcontrib><creatorcontrib>van Amsterdam, J G; C</creatorcontrib><title>Effect of l-NAME, an inhibitor of nitric oxide synthesis, on plasma levels of IL-6, IL-8, TNF[alpha] and nitrite/nitrate in human septic shock</title><title>Intensive care medicine</title><description>Objectives: We tested the effects of N^sup G^-nitro-L-arginine methyl ester (l-NAME), an inhibitor of nitric oxide (NO) synthesis, on plasma levels of interleukin (IL) IL-6, IL-8, tumor necrosis factor-alpha (TNFα) and nitrite/nitrate (NO^sub 2^^sup -^/NO^sub 3^^sup -^) in patients with severe septic shock. Design: Prospective clinical study. Setting: Surgical intensive care unit at a university hospital. Patients: 11 consecutive patients with severe septic shock. Interventions: Standard hemodynamic measurements were made and blood samples taken at intervals before, during, and after a 12-h infusion of l-NAME 1 mg · kg^sup -1^ ·h^sup -1^ for determination of plasma IL-6, IL-8, TNFα and NO^sub 2^^sup -^/NO^sub 3^^sup -^ concentration. Measurements and results: Patients with sepsis had increased plasma levels of IL-6, IL-8, TNFα, and NO^sub 2^^sup -^/NO^sub 3^^sup -^ (p<0.05). Plasma levels of IL-6, IL-8, and NO^sub 2^^sup -^/NO^sub 3^^sup -^ were negatively correlated with systemic vascular resistance (r=-0.62, r=-0.65, and r=-0.78, respectively, all p<0.05). Continuous infusion of l-NAME increased mean arterial pressure and systemic vascular resistance, with a concomitant reduction in cardiac output (all p<0.01). No significant changes were seen in levels of plasma IL-6, IL-8, and NO^sub 2^^sup -^/NO^sub 3^^sup -^ during the 24-h observation period. Plasma levels of TNFα were significantly reduced during l-NAME infusion compared to baseline (p<0.05). Conclusions: NO plays a role in the cardiovascular derangements of human septic shock. Inhibition of NO synthesis with l-NAME does not promote excessive cytokine release in patients with severe sepsis.[PUBLICATION ABSTRACT]</description><subject>Angina pectoris</subject><subject>Blood pressure</subject><subject>Cytokines</subject><subject>Endothelium</subject><subject>Hemodynamics</subject><subject>Hospitals</subject><subject>Hypotension</subject><subject>Intensive care</subject><subject>Nitrates</subject><subject>Nitric oxide</subject><subject>Plasma</subject><subject>Pulmonary arteries</subject><subject>Sepsis</subject><subject>Surgery</subject><subject>Tumor necrosis factor-TNF</subject><subject>Veins & arteries</subject><subject>Ventilators</subject><issn>0342-4642</issn><issn>1432-1238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNjUFOwzAQRS0EEqGwZD9iHVM7dtJmiVAqkKCr7ipUmdSRXVw7ZBwEl-DMOIIDsJkvzX96n5Brzm45Y4s5MsaFZKxklRQnJONSFJQXYnlKMiZkQWUli3NygXhI5KIqeUa-m67TbYTQgaPru-cmB-XBemNfbQzD9Pc2DraF8Gn3GvDLR6PRYg7BQ-8UHhU4_aEdTuzjE63y6S5z2KxXW-V6o16Scv-riXo-pYo6bYAZj2kMdR-TH01o3y7JWacc6qu_nJGbVbO5f6D9EN5HjXF3COPgU7Wr67KsOS8L8S_oB2PBWAk</recordid><startdate>19980701</startdate><enddate>19980701</enddate><creator>Avontuur, J A; M</creator><creator>Stam, T C</creator><creator>Eggermont, A M; M</creator><creator>Braining, H A</creator><creator>Jongen-lavrencic, M</creator><creator>van Amsterdam, J G; C</creator><general>Springer Nature B.V</general><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>19980701</creationdate><title>Effect of l-NAME, an inhibitor of nitric oxide synthesis, on plasma levels of IL-6, IL-8, TNF[alpha] and nitrite/nitrate in human septic shock</title><author>Avontuur, J A; M ; Stam, T C ; Eggermont, A M; M ; Braining, H A ; Jongen-lavrencic, M ; van Amsterdam, J G; C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_9955911523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Angina pectoris</topic><topic>Blood pressure</topic><topic>Cytokines</topic><topic>Endothelium</topic><topic>Hemodynamics</topic><topic>Hospitals</topic><topic>Hypotension</topic><topic>Intensive care</topic><topic>Nitrates</topic><topic>Nitric oxide</topic><topic>Plasma</topic><topic>Pulmonary arteries</topic><topic>Sepsis</topic><topic>Surgery</topic><topic>Tumor necrosis factor-TNF</topic><topic>Veins & arteries</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Avontuur, J A; M</creatorcontrib><creatorcontrib>Stam, T C</creatorcontrib><creatorcontrib>Eggermont, A M; M</creatorcontrib><creatorcontrib>Braining, H A</creatorcontrib><creatorcontrib>Jongen-lavrencic, M</creatorcontrib><creatorcontrib>van Amsterdam, J G; C</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Intensive care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Avontuur, J A; M</au><au>Stam, T C</au><au>Eggermont, A M; M</au><au>Braining, H A</au><au>Jongen-lavrencic, M</au><au>van Amsterdam, J G; C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of l-NAME, an inhibitor of nitric oxide synthesis, on plasma levels of IL-6, IL-8, TNF[alpha] and nitrite/nitrate in human septic shock</atitle><jtitle>Intensive care medicine</jtitle><date>1998-07-01</date><risdate>1998</risdate><volume>24</volume><issue>7</issue><spage>673</spage><pages>673-</pages><issn>0342-4642</issn><eissn>1432-1238</eissn><abstract>Objectives: We tested the effects of N^sup G^-nitro-L-arginine methyl ester (l-NAME), an inhibitor of nitric oxide (NO) synthesis, on plasma levels of interleukin (IL) IL-6, IL-8, tumor necrosis factor-alpha (TNFα) and nitrite/nitrate (NO^sub 2^^sup -^/NO^sub 3^^sup -^) in patients with severe septic shock. Design: Prospective clinical study. Setting: Surgical intensive care unit at a university hospital. Patients: 11 consecutive patients with severe septic shock. Interventions: Standard hemodynamic measurements were made and blood samples taken at intervals before, during, and after a 12-h infusion of l-NAME 1 mg · kg^sup -1^ ·h^sup -1^ for determination of plasma IL-6, IL-8, TNFα and NO^sub 2^^sup -^/NO^sub 3^^sup -^ concentration. Measurements and results: Patients with sepsis had increased plasma levels of IL-6, IL-8, TNFα, and NO^sub 2^^sup -^/NO^sub 3^^sup -^ (p<0.05). Plasma levels of IL-6, IL-8, and NO^sub 2^^sup -^/NO^sub 3^^sup -^ were negatively correlated with systemic vascular resistance (r=-0.62, r=-0.65, and r=-0.78, respectively, all p<0.05). Continuous infusion of l-NAME increased mean arterial pressure and systemic vascular resistance, with a concomitant reduction in cardiac output (all p<0.01). No significant changes were seen in levels of plasma IL-6, IL-8, and NO^sub 2^^sup -^/NO^sub 3^^sup -^ during the 24-h observation period. Plasma levels of TNFα were significantly reduced during l-NAME infusion compared to baseline (p<0.05). Conclusions: NO plays a role in the cardiovascular derangements of human septic shock. Inhibition of NO synthesis with l-NAME does not promote excessive cytokine release in patients with severe sepsis.[PUBLICATION ABSTRACT]</abstract><cop>Heidelberg</cop><pub>Springer Nature B.V</pub><doi>10.1007/s001340050643</doi></addata></record> |
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| ispartof | Intensive care medicine, 1998-07, Vol.24 (7), p.673 |
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| subjects | Angina pectoris Blood pressure Cytokines Endothelium Hemodynamics Hospitals Hypotension Intensive care Nitrates Nitric oxide Plasma Pulmonary arteries Sepsis Surgery Tumor necrosis factor-TNF Veins & arteries Ventilators |
| title | Effect of l-NAME, an inhibitor of nitric oxide synthesis, on plasma levels of IL-6, IL-8, TNF[alpha] and nitrite/nitrate in human septic shock |
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