Adherence and dosing frequency of common medications for cardiovascular patients
To compare adherence between once-daily (QD) and twice-daily (BID) dosing with chronic-use prescription medications used by patients with cardiovascular disease. Retrospective cohort database analysis. Analysis consisted of 1,077,474 patients aged >18 years with a prescription index date from Jan...
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| Veröffentlicht in: | The American journal of managed care 2012-03, Vol.18 (3), p.139 |
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| creator | Bae, Jay P Dobesh, Paul P Klepser, Donald G Anderson, Johnna D Zagar, Anthony J McCollam, Patrick L Tomlin, Molly E |
| description | To compare adherence between once-daily (QD) and twice-daily (BID) dosing with chronic-use prescription medications used by patients with cardiovascular disease.
Retrospective cohort database analysis.
Analysis consisted of 1,077,474 patients aged >18 years with a prescription index date from January 1 to December 31, 2007, for an antidiabetic, antihyperlipidemic, antiplatelet, or cardiac agent with QD or BID dosing. Adherence (medication possession ratio [MPR]) was the number of days of medication supplied between the first prescription fill date and the subsequent 365 days divided by 365 days. Overall mean MPR and comparisons between dosing frequency groups were assessed with a generalized estimating equation. Covariates included age at index date, gender, Charlson comorbidity index, therapeutic class, dosing frequency, and the interaction between therapeutic class and dosing frequency group.
Overall, the adjusted mean MPR ± standard error (SE) value for QD agents was 13.6% greater than BID agents (0.66 ± 0.0006 vs 0.57 ± 0.0016; P |
| format | Article |
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Retrospective cohort database analysis.
Analysis consisted of 1,077,474 patients aged >18 years with a prescription index date from January 1 to December 31, 2007, for an antidiabetic, antihyperlipidemic, antiplatelet, or cardiac agent with QD or BID dosing. Adherence (medication possession ratio [MPR]) was the number of days of medication supplied between the first prescription fill date and the subsequent 365 days divided by 365 days. Overall mean MPR and comparisons between dosing frequency groups were assessed with a generalized estimating equation. Covariates included age at index date, gender, Charlson comorbidity index, therapeutic class, dosing frequency, and the interaction between therapeutic class and dosing frequency group.
Overall, the adjusted mean MPR ± standard error (SE) value for QD agents was 13.6% greater than BID agents (0.66 ± 0.0006 vs 0.57 ± 0.0016; P <.01). The adjusted mean MPR value for QD agents was 2.9%, 17.5%, and 29.4% greater than BID agents in the antidiabetic, antihyperlipidemic, and antiplatelet therapeutic classes, respectively. For cardiac agents, the adjusted mean MPR value was similar between QD and BID agents. Carvedilol represented approximately 80% of the cardiac agents in the BID group. The adjusted mean MPR ± SE for carvedilol phosphate QD was 0.73 ± 0.0024 and 0.65 ± 0.0027 for carvedilol BID (11% difference; P <.01).
In this large analysis, the QD dosing regimen was related to greater adherence versus a BID regimen.</description><identifier>ISSN: 1088-0224</identifier><identifier>EISSN: 1936-2692</identifier><identifier>PMID: 22435907</identifier><language>eng</language><publisher>United States: MultiMedia Healthcare Inc</publisher><subject>Age Factors ; Anti-Arrhythmia Agents - therapeutic use ; Anticholesteremic Agents - therapeutic use ; Antidiabetics ; Antihypertensive Agents - therapeutic use ; Cardiovascular disease ; Cardiovascular Diseases - drug therapy ; Chronic Disease ; Comparative analysis ; Drug dosages ; Estimating techniques ; Female ; Health Status Indicators ; Humans ; Hypoglycemic Agents - therapeutic use ; Insurance Claim Review ; Male ; Medication Adherence - statistics & numerical data ; Prescription drugs ; Retrospective Studies ; Sex Factors ; Time Factors ; United States</subject><ispartof>The American journal of managed care, 2012-03, Vol.18 (3), p.139</ispartof><rights>Copyright Intellisphere, LLC Mar 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22435907$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bae, Jay P</creatorcontrib><creatorcontrib>Dobesh, Paul P</creatorcontrib><creatorcontrib>Klepser, Donald G</creatorcontrib><creatorcontrib>Anderson, Johnna D</creatorcontrib><creatorcontrib>Zagar, Anthony J</creatorcontrib><creatorcontrib>McCollam, Patrick L</creatorcontrib><creatorcontrib>Tomlin, Molly E</creatorcontrib><title>Adherence and dosing frequency of common medications for cardiovascular patients</title><title>The American journal of managed care</title><addtitle>Am J Manag Care</addtitle><description>To compare adherence between once-daily (QD) and twice-daily (BID) dosing with chronic-use prescription medications used by patients with cardiovascular disease.
Retrospective cohort database analysis.
Analysis consisted of 1,077,474 patients aged >18 years with a prescription index date from January 1 to December 31, 2007, for an antidiabetic, antihyperlipidemic, antiplatelet, or cardiac agent with QD or BID dosing. Adherence (medication possession ratio [MPR]) was the number of days of medication supplied between the first prescription fill date and the subsequent 365 days divided by 365 days. Overall mean MPR and comparisons between dosing frequency groups were assessed with a generalized estimating equation. Covariates included age at index date, gender, Charlson comorbidity index, therapeutic class, dosing frequency, and the interaction between therapeutic class and dosing frequency group.
Overall, the adjusted mean MPR ± standard error (SE) value for QD agents was 13.6% greater than BID agents (0.66 ± 0.0006 vs 0.57 ± 0.0016; P <.01). The adjusted mean MPR value for QD agents was 2.9%, 17.5%, and 29.4% greater than BID agents in the antidiabetic, antihyperlipidemic, and antiplatelet therapeutic classes, respectively. For cardiac agents, the adjusted mean MPR value was similar between QD and BID agents. Carvedilol represented approximately 80% of the cardiac agents in the BID group. The adjusted mean MPR ± SE for carvedilol phosphate QD was 0.73 ± 0.0024 and 0.65 ± 0.0027 for carvedilol BID (11% difference; P <.01).
In this large analysis, the QD dosing regimen was related to greater adherence versus a BID regimen.</description><subject>Age Factors</subject><subject>Anti-Arrhythmia Agents - therapeutic use</subject><subject>Anticholesteremic Agents - therapeutic use</subject><subject>Antidiabetics</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - drug therapy</subject><subject>Chronic Disease</subject><subject>Comparative analysis</subject><subject>Drug dosages</subject><subject>Estimating techniques</subject><subject>Female</subject><subject>Health Status Indicators</subject><subject>Humans</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Insurance Claim Review</subject><subject>Male</subject><subject>Medication Adherence - statistics & numerical data</subject><subject>Prescription drugs</subject><subject>Retrospective Studies</subject><subject>Sex Factors</subject><subject>Time Factors</subject><subject>United States</subject><issn>1088-0224</issn><issn>1936-2692</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1T9tKxDAUDKK4F_0FCb4X0tyaPC6LN1jQh_W5nOaiXbZJTVph_96I69MZZoY5MxdoWWsmKyo1vSyYKFURSvkCrXI-EMKk4vIaLQrFhCbNEr1t7KdLLhiHIVhsY-7DB_bJfc2FPOHosYnDEAMenO0NTH0MGfuYsIFk-_gN2cxHSHgskgtTvkFXHo7Z3Z7vGr0_Puy3z9Xu9ellu9lVI2XNVGlFBemkNp6AEsZKTpSzhtem6yRhILgk0gnfWQFaAYUi15xRa2pfN1yzNbr_yx1TLF3z1B7inEJ52WrJRK0b9Wu6O5vmrvRvx9QPkE7t_372A_83WDM</recordid><startdate>201203</startdate><enddate>201203</enddate><creator>Bae, Jay P</creator><creator>Dobesh, Paul P</creator><creator>Klepser, Donald G</creator><creator>Anderson, Johnna D</creator><creator>Zagar, Anthony J</creator><creator>McCollam, Patrick L</creator><creator>Tomlin, Molly E</creator><general>MultiMedia Healthcare Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>201203</creationdate><title>Adherence and dosing frequency of common medications for cardiovascular patients</title><author>Bae, Jay P ; Dobesh, Paul P ; Klepser, Donald G ; Anderson, Johnna D ; Zagar, Anthony J ; McCollam, Patrick L ; Tomlin, Molly E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p237t-98250b69cf0a85cd6408edc41cbb603a54606e5fbd5a98a2a08e1432dc1f17493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age Factors</topic><topic>Anti-Arrhythmia Agents - therapeutic use</topic><topic>Anticholesteremic Agents - therapeutic use</topic><topic>Antidiabetics</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases - drug therapy</topic><topic>Chronic Disease</topic><topic>Comparative analysis</topic><topic>Drug dosages</topic><topic>Estimating techniques</topic><topic>Female</topic><topic>Health Status Indicators</topic><topic>Humans</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Insurance Claim Review</topic><topic>Male</topic><topic>Medication Adherence - statistics & numerical data</topic><topic>Prescription drugs</topic><topic>Retrospective Studies</topic><topic>Sex Factors</topic><topic>Time Factors</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bae, Jay P</creatorcontrib><creatorcontrib>Dobesh, Paul P</creatorcontrib><creatorcontrib>Klepser, Donald G</creatorcontrib><creatorcontrib>Anderson, Johnna D</creatorcontrib><creatorcontrib>Zagar, Anthony J</creatorcontrib><creatorcontrib>McCollam, Patrick L</creatorcontrib><creatorcontrib>Tomlin, Molly E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>The American journal of managed care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bae, Jay P</au><au>Dobesh, Paul P</au><au>Klepser, Donald G</au><au>Anderson, Johnna D</au><au>Zagar, Anthony J</au><au>McCollam, Patrick L</au><au>Tomlin, Molly E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adherence and dosing frequency of common medications for cardiovascular patients</atitle><jtitle>The American journal of managed care</jtitle><addtitle>Am J Manag Care</addtitle><date>2012-03</date><risdate>2012</risdate><volume>18</volume><issue>3</issue><spage>139</spage><pages>139-</pages><issn>1088-0224</issn><eissn>1936-2692</eissn><abstract>To compare adherence between once-daily (QD) and twice-daily (BID) dosing with chronic-use prescription medications used by patients with cardiovascular disease.
Retrospective cohort database analysis.
Analysis consisted of 1,077,474 patients aged >18 years with a prescription index date from January 1 to December 31, 2007, for an antidiabetic, antihyperlipidemic, antiplatelet, or cardiac agent with QD or BID dosing. Adherence (medication possession ratio [MPR]) was the number of days of medication supplied between the first prescription fill date and the subsequent 365 days divided by 365 days. Overall mean MPR and comparisons between dosing frequency groups were assessed with a generalized estimating equation. Covariates included age at index date, gender, Charlson comorbidity index, therapeutic class, dosing frequency, and the interaction between therapeutic class and dosing frequency group.
Overall, the adjusted mean MPR ± standard error (SE) value for QD agents was 13.6% greater than BID agents (0.66 ± 0.0006 vs 0.57 ± 0.0016; P <.01). The adjusted mean MPR value for QD agents was 2.9%, 17.5%, and 29.4% greater than BID agents in the antidiabetic, antihyperlipidemic, and antiplatelet therapeutic classes, respectively. For cardiac agents, the adjusted mean MPR value was similar between QD and BID agents. Carvedilol represented approximately 80% of the cardiac agents in the BID group. The adjusted mean MPR ± SE for carvedilol phosphate QD was 0.73 ± 0.0024 and 0.65 ± 0.0027 for carvedilol BID (11% difference; P <.01).
In this large analysis, the QD dosing regimen was related to greater adherence versus a BID regimen.</abstract><cop>United States</cop><pub>MultiMedia Healthcare Inc</pub><pmid>22435907</pmid></addata></record> |
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| ispartof | The American journal of managed care, 2012-03, Vol.18 (3), p.139 |
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| language | eng |
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| subjects | Age Factors Anti-Arrhythmia Agents - therapeutic use Anticholesteremic Agents - therapeutic use Antidiabetics Antihypertensive Agents - therapeutic use Cardiovascular disease Cardiovascular Diseases - drug therapy Chronic Disease Comparative analysis Drug dosages Estimating techniques Female Health Status Indicators Humans Hypoglycemic Agents - therapeutic use Insurance Claim Review Male Medication Adherence - statistics & numerical data Prescription drugs Retrospective Studies Sex Factors Time Factors United States |
| title | Adherence and dosing frequency of common medications for cardiovascular patients |
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