Contractile effects of endothelins on isolated human ureter
The aim of our study was to investigate mechanism of action of endothelins 1, 2 and 3 on spontaneous activity, tone and intraluminal pressure of human ureter. Both longitudinal tension and intraluminal pressure were recorded from the isolated segments of proximal human ureter. Endothelins 1, 2 and 3...
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| Veröffentlicht in: | Physiological research 2011-01, Vol.60 (6), p.933-939 |
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| creator | Jankovic, S M Jankovic, S V Stojanovic, V Stojadinovic, D Stojadinovic, M Canovic, D Stefanovic, S |
| description | The aim of our study was to investigate mechanism of action of endothelins 1, 2 and 3 on spontaneous activity, tone and intraluminal pressure of human ureter. Both longitudinal tension and intraluminal pressure were recorded from the isolated segments of proximal human ureter. Endothelins 1, 2 and 3 (5.35x10(-11) M - 5.05x10(-8) M) produced concentration-dependent tonic contraction and sustained increase in intraluminal pressure of isolated preparations of human ureter. Endothelins 1 and 3 produced also concentration-dependent inhibition of spontaneous, phasic contractions of the isolated preparations. Selective antagonist of ET(A) receptors BQ123 and selective antagonist of ET(B) receptors BQ788 produced significant inhibition of endothelin-1-induced tonic contraction (pA(2)=8.80 and 6.55, respectively) and increase in intraluminal pressure (pA(2)=8.68 and 7.02, respectively), while they did not affect endothelin-1-induced inhibition of spontaneous activity. Endothelin 1 produces increase in tone and intraluminal pressure of isolated human ureter acting on both ET(A) and ET(B) receptors, the first one being functionally more important. Only endothelins 1 and 3 inhibit spontaneous, phasic activity of human ureter, but this effect was not blocked by selective antagonists of ET(A) and ET(B) receptors. |
| doi_str_mv | 10.33549/physiolres.932144 |
| format | Article |
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Both longitudinal tension and intraluminal pressure were recorded from the isolated segments of proximal human ureter. Endothelins 1, 2 and 3 (5.35x10(-11) M - 5.05x10(-8) M) produced concentration-dependent tonic contraction and sustained increase in intraluminal pressure of isolated preparations of human ureter. Endothelins 1 and 3 produced also concentration-dependent inhibition of spontaneous, phasic contractions of the isolated preparations. Selective antagonist of ET(A) receptors BQ123 and selective antagonist of ET(B) receptors BQ788 produced significant inhibition of endothelin-1-induced tonic contraction (pA(2)=8.80 and 6.55, respectively) and increase in intraluminal pressure (pA(2)=8.68 and 7.02, respectively), while they did not affect endothelin-1-induced inhibition of spontaneous activity. Endothelin 1 produces increase in tone and intraluminal pressure of isolated human ureter acting on both ET(A) and ET(B) receptors, the first one being functionally more important. Only endothelins 1 and 3 inhibit spontaneous, phasic activity of human ureter, but this effect was not blocked by selective antagonists of ET(A) and ET(B) receptors.</description><identifier>ISSN: 0862-8408</identifier><identifier>EISSN: 1802-9973</identifier><identifier>DOI: 10.33549/physiolres.932144</identifier><identifier>PMID: 21995893</identifier><language>eng</language><publisher>Czech Republic: Institute of Physiology</publisher><subject>Aged ; Endothelin Receptor Antagonists ; Endothelin-1 - pharmacology ; Endothelin-1 - physiology ; Endothelin-2 - pharmacology ; Endothelin-2 - physiology ; Endothelin-3 - pharmacology ; Endothelin-3 - physiology ; Endothelins - pharmacology ; Endothelins - physiology ; Female ; Humans ; Male ; Middle Aged ; Muscle Contraction - drug effects ; Muscle Contraction - physiology ; Muscle, Smooth - drug effects ; Muscle, Smooth - physiology ; Muscular system ; Receptors, Endothelin - physiology ; Rodents ; Studies ; Ureter - drug effects ; Ureter - physiology</subject><ispartof>Physiological research, 2011-01, Vol.60 (6), p.933-939</ispartof><rights>Copyright Institute of Physiology 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c341t-c01ff290c91adf464f68764fbf5fddd6f098b2a631e92ad156ea9a9b23e48dfb3</citedby><cites>FETCH-LOGICAL-c341t-c01ff290c91adf464f68764fbf5fddd6f098b2a631e92ad156ea9a9b23e48dfb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,866,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21995893$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jankovic, S M</creatorcontrib><creatorcontrib>Jankovic, S V</creatorcontrib><creatorcontrib>Stojanovic, V</creatorcontrib><creatorcontrib>Stojadinovic, D</creatorcontrib><creatorcontrib>Stojadinovic, M</creatorcontrib><creatorcontrib>Canovic, D</creatorcontrib><creatorcontrib>Stefanovic, S</creatorcontrib><title>Contractile effects of endothelins on isolated human ureter</title><title>Physiological research</title><addtitle>Physiol Res</addtitle><description>The aim of our study was to investigate mechanism of action of endothelins 1, 2 and 3 on spontaneous activity, tone and intraluminal pressure of human ureter. Both longitudinal tension and intraluminal pressure were recorded from the isolated segments of proximal human ureter. Endothelins 1, 2 and 3 (5.35x10(-11) M - 5.05x10(-8) M) produced concentration-dependent tonic contraction and sustained increase in intraluminal pressure of isolated preparations of human ureter. Endothelins 1 and 3 produced also concentration-dependent inhibition of spontaneous, phasic contractions of the isolated preparations. Selective antagonist of ET(A) receptors BQ123 and selective antagonist of ET(B) receptors BQ788 produced significant inhibition of endothelin-1-induced tonic contraction (pA(2)=8.80 and 6.55, respectively) and increase in intraluminal pressure (pA(2)=8.68 and 7.02, respectively), while they did not affect endothelin-1-induced inhibition of spontaneous activity. Endothelin 1 produces increase in tone and intraluminal pressure of isolated human ureter acting on both ET(A) and ET(B) receptors, the first one being functionally more important. Only endothelins 1 and 3 inhibit spontaneous, phasic activity of human ureter, but this effect was not blocked by selective antagonists of ET(A) and ET(B) receptors.</description><subject>Aged</subject><subject>Endothelin Receptor Antagonists</subject><subject>Endothelin-1 - pharmacology</subject><subject>Endothelin-1 - physiology</subject><subject>Endothelin-2 - pharmacology</subject><subject>Endothelin-2 - physiology</subject><subject>Endothelin-3 - pharmacology</subject><subject>Endothelin-3 - physiology</subject><subject>Endothelins - pharmacology</subject><subject>Endothelins - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle Contraction - physiology</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscle, Smooth - physiology</subject><subject>Muscular system</subject><subject>Receptors, Endothelin - physiology</subject><subject>Rodents</subject><subject>Studies</subject><subject>Ureter - 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pharmacology</topic><topic>Endothelin-1 - physiology</topic><topic>Endothelin-2 - pharmacology</topic><topic>Endothelin-2 - physiology</topic><topic>Endothelin-3 - pharmacology</topic><topic>Endothelin-3 - physiology</topic><topic>Endothelins - pharmacology</topic><topic>Endothelins - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle Contraction - physiology</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscle, Smooth - physiology</topic><topic>Muscular system</topic><topic>Receptors, Endothelin - physiology</topic><topic>Rodents</topic><topic>Studies</topic><topic>Ureter - drug effects</topic><topic>Ureter - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jankovic, S M</creatorcontrib><creatorcontrib>Jankovic, S V</creatorcontrib><creatorcontrib>Stojanovic, V</creatorcontrib><creatorcontrib>Stojadinovic, D</creatorcontrib><creatorcontrib>Stojadinovic, M</creatorcontrib><creatorcontrib>Canovic, D</creatorcontrib><creatorcontrib>Stefanovic, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Physiological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jankovic, S M</au><au>Jankovic, S V</au><au>Stojanovic, V</au><au>Stojadinovic, D</au><au>Stojadinovic, M</au><au>Canovic, D</au><au>Stefanovic, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contractile effects of endothelins on isolated human ureter</atitle><jtitle>Physiological research</jtitle><addtitle>Physiol Res</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>60</volume><issue>6</issue><spage>933</spage><epage>939</epage><pages>933-939</pages><issn>0862-8408</issn><eissn>1802-9973</eissn><abstract>The aim of our study was to investigate mechanism of action of endothelins 1, 2 and 3 on spontaneous activity, tone and intraluminal pressure of human ureter. Both longitudinal tension and intraluminal pressure were recorded from the isolated segments of proximal human ureter. Endothelins 1, 2 and 3 (5.35x10(-11) M - 5.05x10(-8) M) produced concentration-dependent tonic contraction and sustained increase in intraluminal pressure of isolated preparations of human ureter. Endothelins 1 and 3 produced also concentration-dependent inhibition of spontaneous, phasic contractions of the isolated preparations. Selective antagonist of ET(A) receptors BQ123 and selective antagonist of ET(B) receptors BQ788 produced significant inhibition of endothelin-1-induced tonic contraction (pA(2)=8.80 and 6.55, respectively) and increase in intraluminal pressure (pA(2)=8.68 and 7.02, respectively), while they did not affect endothelin-1-induced inhibition of spontaneous activity. Endothelin 1 produces increase in tone and intraluminal pressure of isolated human ureter acting on both ET(A) and ET(B) receptors, the first one being functionally more important. Only endothelins 1 and 3 inhibit spontaneous, phasic activity of human ureter, but this effect was not blocked by selective antagonists of ET(A) and ET(B) receptors.</abstract><cop>Czech Republic</cop><pub>Institute of Physiology</pub><pmid>21995893</pmid><doi>10.33549/physiolres.932144</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Endothelin Receptor Antagonists Endothelin-1 - pharmacology Endothelin-1 - physiology Endothelin-2 - pharmacology Endothelin-2 - physiology Endothelin-3 - pharmacology Endothelin-3 - physiology Endothelins - pharmacology Endothelins - physiology Female Humans Male Middle Aged Muscle Contraction - drug effects Muscle Contraction - physiology Muscle, Smooth - drug effects Muscle, Smooth - physiology Muscular system Receptors, Endothelin - physiology Rodents Studies Ureter - drug effects Ureter - physiology |
| title | Contractile effects of endothelins on isolated human ureter |
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