Effect of the antitumoral alkylating agent 3-bromopyruvate on mitochondrial respiration: role of mitochondrially bound hexokinase

The alkylating agent 3-Bromopyruvate (3-BrPA) has been used as an anti-tumoral drug due to its anti-proliferative property in hepatomas cells. This propriety is believed to disturb glycolysis and respiration, which leads to a decreased rate of ATP synthesis. In this study, we evaluated the effects o...

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Veröffentlicht in:	Journal of bioenergetics and biomembranes 2012-02, Vol.44 (1), p.39-49
Hauptverfasser:	Rodrigues-Ferreira, Clara, da Silva, Ana Paula Pereira, Galina, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine diphosphate Animal Anatomy Animal Biochemistry Animals Antineoplastic Agents, Alkylating - pharmacology ATP Biochemistry Bioenergetics Bioorganic Chemistry Brain - metabolism Cancer therapies Cell Respiration - drug effects Chemistry Chemistry and Materials Science Deoxyglucose Glucose-6-Phosphate Hep G2 Cells Hexokinase - metabolism Histology Humans Liver - metabolism Liver cancer Male Membrane Potential, Mitochondrial Mice Mitochondria Mitochondria - drug effects Mitochondria - enzymology Morphology Organic Chemistry Oxygen Consumption Pyruvates - pharmacology Respiration Spectrometry, Fluorescence Succinate Dehydrogenase - metabolism Yeasts
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