The molecular interaction of a copper chelate with human P-glycoprotein

One of the major reasons for multidrug resistance (MDR) in cancer is the overexpression of P-glycoprotein (P-gp, ABCB1), a drug efflux pump. A novel copper complex, namely, copper (II) N-(2-hydroxyacetophenone) glycinate (CuNG) previously synthesized and characterized by the authors had been tested...

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Veröffentlicht in:	Molecular and cellular biochemistry 2012-05, Vol.364 (1-2), p.309-320
Hauptverfasser:	Ghosh, Ruma Dey, Chakraborty, Paramita, Banerjee, Kaushik, Adhikary, Arghya, Sarkar, Avijit, Chatterjee, Mitali, Das, Tanya, Choudhuri, Soumitra Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Adenosine Triphosphatases - metabolism Animals Anthracyclines ATP Binding Cassette Transporter, Sub-Family B ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Biochemistry Biomedical and Life Sciences Cardiology Cell Line Chelating Agents - chemistry Chelating Agents - pharmacology Chromophores Copper Copper compounds Doxorubicin - pharmacology Drug interactions Drug resistance Fibroblasts - metabolism Gene expression Glycine - analogs & derivatives Glycine - chemistry Glycine - pharmacology Glycoproteins Hormones, Sex Humans Immunoglobulins Life Sciences Medical Biochemistry Mice Molecular biology Monoclonal antibodies Oncology Organometallic Compounds - chemistry Organometallic Compounds - pharmacology RNA Toy industry
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