Peroxisome proliferator-activated receptor-[gamma] agonists repress epithelial sodium channel expression in the kidney

Thiazolidinediones (TZDs), known as peroxisome proliferator-activated receptor (PPAR) agonists, are used to treat type 2 diabetes. However, ~5% of patients experience the treatment-limiting side effect of edema. Studies have implicated activation of the epithelial sodium channel (ENaC) as a cause of...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2012-03, Vol.302 (5), p.F540
Hauptverfasser:	Borsting, Emily, Cheng, Vicki Pei-Chun, Glass, Chris K, Vallon, Volker, Cunard, Robyn
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatin Diabetes Gene expression Kidneys Proteins Rodents T cell receptors
Online-Zugang:	Volltext
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