Association between the STin2 VNTR polymorphism and smoking behavior in oral cancer patients and healthy individuals
The serotonergic system may be involved in smoking behavior since the intake of nicotine increases serotonin secretion in the CNS. Moreover, evidence supporting the beneficial effect of selective serotonin reuptake for quitting smoking suggesting that the serotonin transporter (5-HTT) is a plausible...
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creator | de Lima, Kalil William Alves Guembarovski, Roberta Losi Oda, Julie Massayo Maeda Ramos, Gyl Oliveira, Benedito Valdecir Cavalli, Iglenir João de Souza Fonseca Ribeiro, Enilze Maria Gonçalves, Marlene Silva Bardi Aoki, Mateus Nobrega Nunes, Sandra Odebrecht Vargas Watanabe, Maria Angelica Ehara |
description | The serotonergic system may be involved in smoking behavior since the intake of nicotine increases serotonin secretion in the CNS. Moreover, evidence supporting the beneficial effect of selective serotonin reuptake for quitting smoking suggesting that the serotonin transporter (5-HTT) is a plausible target for the understanding and elucidation of smoking behavior. The transcriptional activity of its human gene (SLC6A4) is modulated by a polymorphism described in the second intron, the STin2 VNTR, which thus may interfere with 5-HTT synthesis. In this study was analyzed the polymorphism STin2 VNTR of 60 smokers male patients diagnosed for oral carcinoma, 61 male smokers without cancer and 65 non-smoker healthy blood donors. The STin2. 9 allele carriers were more present in smoker groups (with cancer and without cancer, respectively) than in the non-smoker (OR = 7.11, 95% CI = 0.83–60.91 and OR = 24.73; IC 95% = 3.17–192.66). Conversely, individuals carrying allele 10 were more prevalent in non-smokers compared with smokers (oral cancer patients and individuals without cancer, respectively), showing a protective factor of this allele (OR = 0.56; 95% CI = 0.24–1.33 and OR = 0.46; 95% CI = 0.20–1.07). This is the first report of a study assessing the importance of STin2 VNTR smoking behavior in Brazilian individuals and the association of STin2. 9 allele carriers in nicotine dependence. It is suggested that individuals with low serotonin concentration in the central nervous system, probably due to the presence of the allele for high expression of 5-HTT,especially STin2. 9, were more susceptible to nicotine dependence. Moreover, individuals with the 10 allele might have less risk for nicotine dependence. |
doi_str_mv | 10.1007/s10238-011-0140-y |
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Moreover, evidence supporting the beneficial effect of selective serotonin reuptake for quitting smoking suggesting that the serotonin transporter (5-HTT) is a plausible target for the understanding and elucidation of smoking behavior. The transcriptional activity of its human gene (SLC6A4) is modulated by a polymorphism described in the second intron, the STin2 VNTR, which thus may interfere with 5-HTT synthesis. In this study was analyzed the polymorphism STin2 VNTR of 60 smokers male patients diagnosed for oral carcinoma, 61 male smokers without cancer and 65 non-smoker healthy blood donors. The STin2. 9 allele carriers were more present in smoker groups (with cancer and without cancer, respectively) than in the non-smoker (OR = 7.11, 95% CI = 0.83–60.91 and OR = 24.73; IC 95% = 3.17–192.66). Conversely, individuals carrying allele 10 were more prevalent in non-smokers compared with smokers (oral cancer patients and individuals without cancer, respectively), showing a protective factor of this allele (OR = 0.56; 95% CI = 0.24–1.33 and OR = 0.46; 95% CI = 0.20–1.07). This is the first report of a study assessing the importance of STin2 VNTR smoking behavior in Brazilian individuals and the association of STin2. 9 allele carriers in nicotine dependence. It is suggested that individuals with low serotonin concentration in the central nervous system, probably due to the presence of the allele for high expression of 5-HTT,especially STin2. 9, were more susceptible to nicotine dependence. Moreover, individuals with the 10 allele might have less risk for nicotine dependence.</description><identifier>ISSN: 1591-8890</identifier><identifier>EISSN: 1591-9528</identifier><identifier>DOI: 10.1007/s10238-011-0140-y</identifier><identifier>PMID: 21626393</identifier><identifier>CODEN: CEMLBA</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Aged ; Alleles ; Brazil - epidemiology ; Carcinoma, Squamous Cell - epidemiology ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - pathology ; Case-Control Studies ; Electrophoresis, Polyacrylamide Gel ; Gene Frequency ; Genome, Human ; Genotype ; Hematology ; Humans ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mouth Neoplasms - epidemiology ; Mouth Neoplasms - genetics ; Mouth Neoplasms - pathology ; Oncology ; Oral cancer ; Original Article ; Patients ; Polymorphism ; Polymorphism, Genetic ; Serotonin - metabolism ; Serotonin Plasma Membrane Transport Proteins - genetics ; Serotonin Plasma Membrane Transport Proteins - metabolism ; Smoking ; Smoking - epidemiology ; Smoking - genetics ; Smoking - pathology ; Smoking - psychology ; Tobacco Use Disorder - epidemiology ; Tobacco Use Disorder - genetics ; Tobacco Use Disorder - pathology ; Tobacco Use Disorder - psychology ; Transcriptional Activation</subject><ispartof>Clinical and experimental medicine, 2012-03, Vol.12 (1), p.13-19</ispartof><rights>Springer-Verlag 2011</rights><rights>Springer-Verlag 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-178966acfadab02912268492a77bda10cde94c390c02a6abb06d7787c0579ca83</citedby><cites>FETCH-LOGICAL-c370t-178966acfadab02912268492a77bda10cde94c390c02a6abb06d7787c0579ca83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10238-011-0140-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10238-011-0140-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21626393$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Lima, Kalil William Alves</creatorcontrib><creatorcontrib>Guembarovski, Roberta Losi</creatorcontrib><creatorcontrib>Oda, Julie Massayo Maeda</creatorcontrib><creatorcontrib>Ramos, Gyl</creatorcontrib><creatorcontrib>Oliveira, Benedito Valdecir</creatorcontrib><creatorcontrib>Cavalli, Iglenir João</creatorcontrib><creatorcontrib>de Souza Fonseca Ribeiro, Enilze Maria</creatorcontrib><creatorcontrib>Gonçalves, Marlene Silva Bardi</creatorcontrib><creatorcontrib>Aoki, Mateus Nobrega</creatorcontrib><creatorcontrib>Nunes, Sandra Odebrecht Vargas</creatorcontrib><creatorcontrib>Watanabe, Maria Angelica Ehara</creatorcontrib><title>Association between the STin2 VNTR polymorphism and smoking behavior in oral cancer patients and healthy individuals</title><title>Clinical and experimental medicine</title><addtitle>Clin Exp Med</addtitle><addtitle>Clin Exp Med</addtitle><description>The serotonergic system may be involved in smoking behavior since the intake of nicotine increases serotonin secretion in the CNS. Moreover, evidence supporting the beneficial effect of selective serotonin reuptake for quitting smoking suggesting that the serotonin transporter (5-HTT) is a plausible target for the understanding and elucidation of smoking behavior. The transcriptional activity of its human gene (SLC6A4) is modulated by a polymorphism described in the second intron, the STin2 VNTR, which thus may interfere with 5-HTT synthesis. In this study was analyzed the polymorphism STin2 VNTR of 60 smokers male patients diagnosed for oral carcinoma, 61 male smokers without cancer and 65 non-smoker healthy blood donors. The STin2. 9 allele carriers were more present in smoker groups (with cancer and without cancer, respectively) than in the non-smoker (OR = 7.11, 95% CI = 0.83–60.91 and OR = 24.73; IC 95% = 3.17–192.66). Conversely, individuals carrying allele 10 were more prevalent in non-smokers compared with smokers (oral cancer patients and individuals without cancer, respectively), showing a protective factor of this allele (OR = 0.56; 95% CI = 0.24–1.33 and OR = 0.46; 95% CI = 0.20–1.07). This is the first report of a study assessing the importance of STin2 VNTR smoking behavior in Brazilian individuals and the association of STin2. 9 allele carriers in nicotine dependence. It is suggested that individuals with low serotonin concentration in the central nervous system, probably due to the presence of the allele for high expression of 5-HTT,especially STin2. 9, were more susceptible to nicotine dependence. Moreover, individuals with the 10 allele might have less risk for nicotine dependence.</description><subject>Aged</subject><subject>Alleles</subject><subject>Brazil - epidemiology</subject><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Case-Control Studies</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Gene Frequency</subject><subject>Genome, Human</subject><subject>Genotype</subject><subject>Hematology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - epidemiology</subject><subject>Mouth Neoplasms - genetics</subject><subject>Mouth Neoplasms - pathology</subject><subject>Oncology</subject><subject>Oral cancer</subject><subject>Original Article</subject><subject>Patients</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Serotonin - metabolism</subject><subject>Serotonin Plasma Membrane Transport Proteins - genetics</subject><subject>Serotonin Plasma Membrane Transport Proteins - metabolism</subject><subject>Smoking</subject><subject>Smoking - epidemiology</subject><subject>Smoking - genetics</subject><subject>Smoking - pathology</subject><subject>Smoking - psychology</subject><subject>Tobacco Use Disorder - epidemiology</subject><subject>Tobacco Use Disorder - genetics</subject><subject>Tobacco Use Disorder - pathology</subject><subject>Tobacco Use Disorder - psychology</subject><subject>Transcriptional Activation</subject><issn>1591-8890</issn><issn>1591-9528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kE1LxDAQhoMofv8ALxK8VyfpNh9HEb9AFHT1GtI0a6PbpCZdpf_e6K568jDMwDzzDjwIHRA4JgD8JBGgpSiAkFwTKMY1tE0qSQpZUbG-moWQsIV2UnoBIJUoYRNtUcIoK2W5jYbTlIJxenDB49oOH9Z6PLQWP0ydp_jpdnqP-zAfuxD71qUOa9_g1IVX558z3-p3FyJ2Hoeo59hob2zEfY6zfkjfcGv1fGjHzDTu3TULPU97aGOWm91f9V30eHE-Pbsqbu4ur89ObwpTchgKwoVkTJuZbnQNVBJKmZhIqjmvG03ANFZOTCnBANVM1zWwhnPBDVRcGi3KXXS0zO1jeFvYNKiXsIg-v1SSskrQSrIMkSVkYkgp2pnqo-t0HBUB9aVZLTWrrFl9aVZjvjlcBS_qzja_Fz9eM0CXQMor_2zj3-f_Uz8BtWSJuw</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>de Lima, Kalil William Alves</creator><creator>Guembarovski, Roberta Losi</creator><creator>Oda, Julie Massayo Maeda</creator><creator>Ramos, Gyl</creator><creator>Oliveira, Benedito Valdecir</creator><creator>Cavalli, Iglenir João</creator><creator>de Souza Fonseca Ribeiro, Enilze Maria</creator><creator>Gonçalves, Marlene Silva Bardi</creator><creator>Aoki, Mateus Nobrega</creator><creator>Nunes, Sandra Odebrecht Vargas</creator><creator>Watanabe, Maria Angelica Ehara</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20120301</creationdate><title>Association between the STin2 VNTR polymorphism and smoking behavior in oral cancer patients and healthy individuals</title><author>de Lima, Kalil William Alves ; Guembarovski, Roberta Losi ; Oda, Julie Massayo Maeda ; Ramos, Gyl ; Oliveira, Benedito Valdecir ; Cavalli, Iglenir João ; de Souza Fonseca Ribeiro, Enilze Maria ; Gonçalves, Marlene Silva Bardi ; Aoki, Mateus Nobrega ; Nunes, Sandra Odebrecht Vargas ; Watanabe, Maria Angelica Ehara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-178966acfadab02912268492a77bda10cde94c390c02a6abb06d7787c0579ca83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Alleles</topic><topic>Brazil - epidemiology</topic><topic>Carcinoma, Squamous Cell - epidemiology</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Case-Control Studies</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Gene Frequency</topic><topic>Genome, Human</topic><topic>Genotype</topic><topic>Hematology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - epidemiology</topic><topic>Mouth Neoplasms - genetics</topic><topic>Mouth Neoplasms - pathology</topic><topic>Oncology</topic><topic>Oral cancer</topic><topic>Original Article</topic><topic>Patients</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Serotonin - metabolism</topic><topic>Serotonin Plasma Membrane Transport Proteins - genetics</topic><topic>Serotonin Plasma Membrane Transport Proteins - metabolism</topic><topic>Smoking</topic><topic>Smoking - 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Moreover, evidence supporting the beneficial effect of selective serotonin reuptake for quitting smoking suggesting that the serotonin transporter (5-HTT) is a plausible target for the understanding and elucidation of smoking behavior. The transcriptional activity of its human gene (SLC6A4) is modulated by a polymorphism described in the second intron, the STin2 VNTR, which thus may interfere with 5-HTT synthesis. In this study was analyzed the polymorphism STin2 VNTR of 60 smokers male patients diagnosed for oral carcinoma, 61 male smokers without cancer and 65 non-smoker healthy blood donors. The STin2. 9 allele carriers were more present in smoker groups (with cancer and without cancer, respectively) than in the non-smoker (OR = 7.11, 95% CI = 0.83–60.91 and OR = 24.73; IC 95% = 3.17–192.66). Conversely, individuals carrying allele 10 were more prevalent in non-smokers compared with smokers (oral cancer patients and individuals without cancer, respectively), showing a protective factor of this allele (OR = 0.56; 95% CI = 0.24–1.33 and OR = 0.46; 95% CI = 0.20–1.07). This is the first report of a study assessing the importance of STin2 VNTR smoking behavior in Brazilian individuals and the association of STin2. 9 allele carriers in nicotine dependence. It is suggested that individuals with low serotonin concentration in the central nervous system, probably due to the presence of the allele for high expression of 5-HTT,especially STin2. 9, were more susceptible to nicotine dependence. Moreover, individuals with the 10 allele might have less risk for nicotine dependence.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>21626393</pmid><doi>10.1007/s10238-011-0140-y</doi><tpages>7</tpages></addata></record> |
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subjects | Aged Alleles Brazil - epidemiology Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Case-Control Studies Electrophoresis, Polyacrylamide Gel Gene Frequency Genome, Human Genotype Hematology Humans Internal Medicine Male Medicine Medicine & Public Health Middle Aged Mouth Neoplasms - epidemiology Mouth Neoplasms - genetics Mouth Neoplasms - pathology Oncology Oral cancer Original Article Patients Polymorphism Polymorphism, Genetic Serotonin - metabolism Serotonin Plasma Membrane Transport Proteins - genetics Serotonin Plasma Membrane Transport Proteins - metabolism Smoking Smoking - epidemiology Smoking - genetics Smoking - pathology Smoking - psychology Tobacco Use Disorder - epidemiology Tobacco Use Disorder - genetics Tobacco Use Disorder - pathology Tobacco Use Disorder - psychology Transcriptional Activation |
title | Association between the STin2 VNTR polymorphism and smoking behavior in oral cancer patients and healthy individuals |
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