Association between the STin2 VNTR polymorphism and smoking behavior in oral cancer patients and healthy individuals

The serotonergic system may be involved in smoking behavior since the intake of nicotine increases serotonin secretion in the CNS. Moreover, evidence supporting the beneficial effect of selective serotonin reuptake for quitting smoking suggesting that the serotonin transporter (5-HTT) is a plausible...

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Veröffentlicht in:Clinical and experimental medicine 2012-03, Vol.12 (1), p.13-19
Hauptverfasser: de Lima, Kalil William Alves, Guembarovski, Roberta Losi, Oda, Julie Massayo Maeda, Ramos, Gyl, Oliveira, Benedito Valdecir, Cavalli, Iglenir João, de Souza Fonseca Ribeiro, Enilze Maria, Gonçalves, Marlene Silva Bardi, Aoki, Mateus Nobrega, Nunes, Sandra Odebrecht Vargas, Watanabe, Maria Angelica Ehara
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container_issue 1
container_start_page 13
container_title Clinical and experimental medicine
container_volume 12
creator de Lima, Kalil William Alves
Guembarovski, Roberta Losi
Oda, Julie Massayo Maeda
Ramos, Gyl
Oliveira, Benedito Valdecir
Cavalli, Iglenir João
de Souza Fonseca Ribeiro, Enilze Maria
Gonçalves, Marlene Silva Bardi
Aoki, Mateus Nobrega
Nunes, Sandra Odebrecht Vargas
Watanabe, Maria Angelica Ehara
description The serotonergic system may be involved in smoking behavior since the intake of nicotine increases serotonin secretion in the CNS. Moreover, evidence supporting the beneficial effect of selective serotonin reuptake for quitting smoking suggesting that the serotonin transporter (5-HTT) is a plausible target for the understanding and elucidation of smoking behavior. The transcriptional activity of its human gene (SLC6A4) is modulated by a polymorphism described in the second intron, the STin2 VNTR, which thus may interfere with 5-HTT synthesis. In this study was analyzed the polymorphism STin2 VNTR of 60 smokers male patients diagnosed for oral carcinoma, 61 male smokers without cancer and 65 non-smoker healthy blood donors. The STin2. 9 allele carriers were more present in smoker groups (with cancer and without cancer, respectively) than in the non-smoker (OR = 7.11, 95% CI = 0.83–60.91 and OR = 24.73; IC 95% = 3.17–192.66). Conversely, individuals carrying allele 10 were more prevalent in non-smokers compared with smokers (oral cancer patients and individuals without cancer, respectively), showing a protective factor of this allele (OR = 0.56; 95% CI = 0.24–1.33 and OR = 0.46; 95% CI = 0.20–1.07). This is the first report of a study assessing the importance of STin2 VNTR smoking behavior in Brazilian individuals and the association of STin2. 9 allele carriers in nicotine dependence. It is suggested that individuals with low serotonin concentration in the central nervous system, probably due to the presence of the allele for high expression of 5-HTT,especially STin2. 9, were more susceptible to nicotine dependence. Moreover, individuals with the 10 allele might have less risk for nicotine dependence.
doi_str_mv 10.1007/s10238-011-0140-y
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Moreover, evidence supporting the beneficial effect of selective serotonin reuptake for quitting smoking suggesting that the serotonin transporter (5-HTT) is a plausible target for the understanding and elucidation of smoking behavior. The transcriptional activity of its human gene (SLC6A4) is modulated by a polymorphism described in the second intron, the STin2 VNTR, which thus may interfere with 5-HTT synthesis. In this study was analyzed the polymorphism STin2 VNTR of 60 smokers male patients diagnosed for oral carcinoma, 61 male smokers without cancer and 65 non-smoker healthy blood donors. The STin2. 9 allele carriers were more present in smoker groups (with cancer and without cancer, respectively) than in the non-smoker (OR = 7.11, 95% CI = 0.83–60.91 and OR = 24.73; IC 95% = 3.17–192.66). Conversely, individuals carrying allele 10 were more prevalent in non-smokers compared with smokers (oral cancer patients and individuals without cancer, respectively), showing a protective factor of this allele (OR = 0.56; 95% CI = 0.24–1.33 and OR = 0.46; 95% CI = 0.20–1.07). This is the first report of a study assessing the importance of STin2 VNTR smoking behavior in Brazilian individuals and the association of STin2. 9 allele carriers in nicotine dependence. It is suggested that individuals with low serotonin concentration in the central nervous system, probably due to the presence of the allele for high expression of 5-HTT,especially STin2. 9, were more susceptible to nicotine dependence. 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Moreover, evidence supporting the beneficial effect of selective serotonin reuptake for quitting smoking suggesting that the serotonin transporter (5-HTT) is a plausible target for the understanding and elucidation of smoking behavior. The transcriptional activity of its human gene (SLC6A4) is modulated by a polymorphism described in the second intron, the STin2 VNTR, which thus may interfere with 5-HTT synthesis. In this study was analyzed the polymorphism STin2 VNTR of 60 smokers male patients diagnosed for oral carcinoma, 61 male smokers without cancer and 65 non-smoker healthy blood donors. The STin2. 9 allele carriers were more present in smoker groups (with cancer and without cancer, respectively) than in the non-smoker (OR = 7.11, 95% CI = 0.83–60.91 and OR = 24.73; IC 95% = 3.17–192.66). Conversely, individuals carrying allele 10 were more prevalent in non-smokers compared with smokers (oral cancer patients and individuals without cancer, respectively), showing a protective factor of this allele (OR = 0.56; 95% CI = 0.24–1.33 and OR = 0.46; 95% CI = 0.20–1.07). This is the first report of a study assessing the importance of STin2 VNTR smoking behavior in Brazilian individuals and the association of STin2. 9 allele carriers in nicotine dependence. It is suggested that individuals with low serotonin concentration in the central nervous system, probably due to the presence of the allele for high expression of 5-HTT,especially STin2. 9, were more susceptible to nicotine dependence. 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Moreover, evidence supporting the beneficial effect of selective serotonin reuptake for quitting smoking suggesting that the serotonin transporter (5-HTT) is a plausible target for the understanding and elucidation of smoking behavior. The transcriptional activity of its human gene (SLC6A4) is modulated by a polymorphism described in the second intron, the STin2 VNTR, which thus may interfere with 5-HTT synthesis. In this study was analyzed the polymorphism STin2 VNTR of 60 smokers male patients diagnosed for oral carcinoma, 61 male smokers without cancer and 65 non-smoker healthy blood donors. The STin2. 9 allele carriers were more present in smoker groups (with cancer and without cancer, respectively) than in the non-smoker (OR = 7.11, 95% CI = 0.83–60.91 and OR = 24.73; IC 95% = 3.17–192.66). Conversely, individuals carrying allele 10 were more prevalent in non-smokers compared with smokers (oral cancer patients and individuals without cancer, respectively), showing a protective factor of this allele (OR = 0.56; 95% CI = 0.24–1.33 and OR = 0.46; 95% CI = 0.20–1.07). This is the first report of a study assessing the importance of STin2 VNTR smoking behavior in Brazilian individuals and the association of STin2. 9 allele carriers in nicotine dependence. It is suggested that individuals with low serotonin concentration in the central nervous system, probably due to the presence of the allele for high expression of 5-HTT,especially STin2. 9, were more susceptible to nicotine dependence. Moreover, individuals with the 10 allele might have less risk for nicotine dependence.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>21626393</pmid><doi>10.1007/s10238-011-0140-y</doi><tpages>7</tpages></addata></record>
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subjects Aged
Alleles
Brazil - epidemiology
Carcinoma, Squamous Cell - epidemiology
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - pathology
Case-Control Studies
Electrophoresis, Polyacrylamide Gel
Gene Frequency
Genome, Human
Genotype
Hematology
Humans
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Mouth Neoplasms - epidemiology
Mouth Neoplasms - genetics
Mouth Neoplasms - pathology
Oncology
Oral cancer
Original Article
Patients
Polymorphism
Polymorphism, Genetic
Serotonin - metabolism
Serotonin Plasma Membrane Transport Proteins - genetics
Serotonin Plasma Membrane Transport Proteins - metabolism
Smoking
Smoking - epidemiology
Smoking - genetics
Smoking - pathology
Smoking - psychology
Tobacco Use Disorder - epidemiology
Tobacco Use Disorder - genetics
Tobacco Use Disorder - pathology
Tobacco Use Disorder - psychology
Transcriptional Activation
title Association between the STin2 VNTR polymorphism and smoking behavior in oral cancer patients and healthy individuals
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