Resveratrol ameliorates oxidative DNA damage and protects against acrylamide-induced oxidative stress in rats
Acrylamide (ACR), used in many fields from industrial manufacturing to laboratory personnel work is also formed during the heating process through interactions of amino acids. Therefore ACR poses a significant risk to human health. This study aimed to elucidate whether resveratrol (RVT) treatment co...
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| Veröffentlicht in: | Molecular biology reports 2012-04, Vol.39 (4), p.4589-4596 |
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| creator | Alturfan, A. Ata Tozan-Beceren, Ayfer Şehirli, Ahmet Özer Demiralp, Emel Şener, Göksel Omurtag, Gülden Zehra |
| description | Acrylamide (ACR), used in many fields from industrial manufacturing to laboratory personnel work is also formed during the heating process through interactions of amino acids. Therefore ACR poses a significant risk to human health. This study aimed to elucidate whether resveratrol (RVT) treatment could modulate ACR-induced oxidative DNA damage and oxidative changes in rat brain, lung, liver, kidney and testes tissues. Rats were divided into four groups as control (C); RVT (30 mg/kg i.p. dissolved in 0.9% NaCl), ACR (40 mg/kg i.p.) and RVT + ACR groups. After 10 days rats were decapitated and tissues were excised. 8-hydroxydeoxyguanosine (8-OHdG) is a biomarker of oxidative DNA damage. 8-OHdG content in the extracted DNA solution was determined by enzyme-linked immunosorbent assay method. Malondialdehyde (MDA), glutathione (GSH) levels and myeloperoxidase activity (MPO) were determined in tissues, while oxidant-induced tissue fibrosis was determined by collagen contents. Serum enzyme activities, cytokine levels, leukocyte apoptosis were assayed in plasma. As an indicator of oxidative DNA damage, 8-OHdG levels significantly increased in ACR group and this was reversed significantly by RVT treatment. In ACR group, GSH levels decreased significantly while the MDA levels, MPO activity and collagen content increased in the tissues suggesting oxidative organ damage. In RVT-treated ACR group, oxidant responses reversed significantly. Serum enzyme activities, cytokine levels and leukocyte late apoptosis which increased following ACR administration, decreased with RVT treatment. Therefore supplementing with RVT can be useful in individuals at risk of ACR toxicity. |
| doi_str_mv | 10.1007/s11033-011-1249-5 |
| format | Article |
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Ata ; Tozan-Beceren, Ayfer ; Şehirli, Ahmet Özer ; Demiralp, Emel ; Şener, Göksel ; Omurtag, Gülden Zehra</creator><creatorcontrib>Alturfan, A. Ata ; Tozan-Beceren, Ayfer ; Şehirli, Ahmet Özer ; Demiralp, Emel ; Şener, Göksel ; Omurtag, Gülden Zehra</creatorcontrib><description>Acrylamide (ACR), used in many fields from industrial manufacturing to laboratory personnel work is also formed during the heating process through interactions of amino acids. Therefore ACR poses a significant risk to human health. This study aimed to elucidate whether resveratrol (RVT) treatment could modulate ACR-induced oxidative DNA damage and oxidative changes in rat brain, lung, liver, kidney and testes tissues. Rats were divided into four groups as control (C); RVT (30 mg/kg i.p. dissolved in 0.9% NaCl), ACR (40 mg/kg i.p.) and RVT + ACR groups. After 10 days rats were decapitated and tissues were excised. 8-hydroxydeoxyguanosine (8-OHdG) is a biomarker of oxidative DNA damage. 8-OHdG content in the extracted DNA solution was determined by enzyme-linked immunosorbent assay method. Malondialdehyde (MDA), glutathione (GSH) levels and myeloperoxidase activity (MPO) were determined in tissues, while oxidant-induced tissue fibrosis was determined by collagen contents. Serum enzyme activities, cytokine levels, leukocyte apoptosis were assayed in plasma. As an indicator of oxidative DNA damage, 8-OHdG levels significantly increased in ACR group and this was reversed significantly by RVT treatment. In ACR group, GSH levels decreased significantly while the MDA levels, MPO activity and collagen content increased in the tissues suggesting oxidative organ damage. In RVT-treated ACR group, oxidant responses reversed significantly. Serum enzyme activities, cytokine levels and leukocyte late apoptosis which increased following ACR administration, decreased with RVT treatment. Therefore supplementing with RVT can be useful in individuals at risk of ACR toxicity.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-011-1249-5</identifier><identifier>PMID: 21947844</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Acrylamide - toxicity ; Alanine Transaminase - blood ; Animal Anatomy ; Animal Biochemistry ; Animals ; Apoptosis ; Apoptosis - drug effects ; Aspartate Aminotransferases - blood ; Biomarkers ; Biomedical and Life Sciences ; Blood Urea Nitrogen ; Creatinine - blood ; Cytokines - blood ; Deoxyguanosine - analogs & derivatives ; Deoxyguanosine - blood ; DNA Damage ; Female ; Glutathione - metabolism ; Histology ; Humans ; L-Lactate Dehydrogenase - blood ; Leukocytes ; Life Sciences ; Lymphocytes - drug effects ; Lymphocytes - pathology ; Male ; Malondialdehyde - metabolism ; Morphology ; Neutrophils - drug effects ; Neutrophils - pathology ; Oxidative stress ; Oxidative Stress - drug effects ; Peroxidase - metabolism ; Protective Agents - pharmacology ; Rats ; Rats, Wistar ; Rodents ; Stilbenes - pharmacology</subject><ispartof>Molecular biology reports, 2012-04, Vol.39 (4), p.4589-4596</ispartof><rights>Springer Science+Business Media B.V. 2011</rights><rights>Springer Science+Business Media B.V. 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p178t-647efc1de4c99b0f94c7125b606002b8bef1f2e38ac7f6fab504c6a749997153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-011-1249-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-011-1249-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21947844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alturfan, A. Ata</creatorcontrib><creatorcontrib>Tozan-Beceren, Ayfer</creatorcontrib><creatorcontrib>Şehirli, Ahmet Özer</creatorcontrib><creatorcontrib>Demiralp, Emel</creatorcontrib><creatorcontrib>Şener, Göksel</creatorcontrib><creatorcontrib>Omurtag, Gülden Zehra</creatorcontrib><title>Resveratrol ameliorates oxidative DNA damage and protects against acrylamide-induced oxidative stress in rats</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>Acrylamide (ACR), used in many fields from industrial manufacturing to laboratory personnel work is also formed during the heating process through interactions of amino acids. Therefore ACR poses a significant risk to human health. This study aimed to elucidate whether resveratrol (RVT) treatment could modulate ACR-induced oxidative DNA damage and oxidative changes in rat brain, lung, liver, kidney and testes tissues. Rats were divided into four groups as control (C); RVT (30 mg/kg i.p. dissolved in 0.9% NaCl), ACR (40 mg/kg i.p.) and RVT + ACR groups. After 10 days rats were decapitated and tissues were excised. 8-hydroxydeoxyguanosine (8-OHdG) is a biomarker of oxidative DNA damage. 8-OHdG content in the extracted DNA solution was determined by enzyme-linked immunosorbent assay method. Malondialdehyde (MDA), glutathione (GSH) levels and myeloperoxidase activity (MPO) were determined in tissues, while oxidant-induced tissue fibrosis was determined by collagen contents. Serum enzyme activities, cytokine levels, leukocyte apoptosis were assayed in plasma. As an indicator of oxidative DNA damage, 8-OHdG levels significantly increased in ACR group and this was reversed significantly by RVT treatment. In ACR group, GSH levels decreased significantly while the MDA levels, MPO activity and collagen content increased in the tissues suggesting oxidative organ damage. In RVT-treated ACR group, oxidant responses reversed significantly. Serum enzyme activities, cytokine levels and leukocyte late apoptosis which increased following ACR administration, decreased with RVT treatment. Therefore supplementing with RVT can be useful in individuals at risk of ACR toxicity.</description><subject>Acrylamide - toxicity</subject><subject>Alanine Transaminase - blood</subject><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Blood Urea Nitrogen</subject><subject>Creatinine - blood</subject><subject>Cytokines - blood</subject><subject>Deoxyguanosine - analogs & derivatives</subject><subject>Deoxyguanosine - blood</subject><subject>DNA Damage</subject><subject>Female</subject><subject>Glutathione - metabolism</subject><subject>Histology</subject><subject>Humans</subject><subject>L-Lactate Dehydrogenase - blood</subject><subject>Leukocytes</subject><subject>Life Sciences</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - pathology</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Morphology</subject><subject>Neutrophils - drug effects</subject><subject>Neutrophils - pathology</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Peroxidase - metabolism</subject><subject>Protective Agents - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Stilbenes - pharmacology</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpNkd9LwzAQx4Mobk7_AF8k-B69a5OmeRzzJwwF2XtI2-vo6I-ZtOL-ezs20adw5HPfO-7D2DXCHQLo-4AIcSwAUWAkjVAnbIpKx0IanZ6yKcSAQqYKJ-wihA0ASNTqnE0iNFKnUk5Z80Hhi7zrfVdz11BddWNBgXffVeH66ov4w9ucF65xa-KuLfjWdz3lfeBu7ao29Nzlfle7pipIVG0x5FT8aw69pxB41fIxNlyys9LVga6O74ytnh5XixexfH9-XcyXYos67UUiNZU5FiRzYzIojcw1RipLIAGIsjSjEsuI4tTlukxKlymQeeK0NMZoVPGM3R5ix10_Bwq93XSDb8eJ1kRJLFUEOEI3R2jIGirs1leN8zv7e5sRiA5AGL_aNfm_FAS7F2APAuwowO4FWBX_AI2Dd7o</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>Alturfan, A. 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Ata</au><au>Tozan-Beceren, Ayfer</au><au>Şehirli, Ahmet Özer</au><au>Demiralp, Emel</au><au>Şener, Göksel</au><au>Omurtag, Gülden Zehra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resveratrol ameliorates oxidative DNA damage and protects against acrylamide-induced oxidative stress in rats</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>39</volume><issue>4</issue><spage>4589</spage><epage>4596</epage><pages>4589-4596</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>Acrylamide (ACR), used in many fields from industrial manufacturing to laboratory personnel work is also formed during the heating process through interactions of amino acids. Therefore ACR poses a significant risk to human health. This study aimed to elucidate whether resveratrol (RVT) treatment could modulate ACR-induced oxidative DNA damage and oxidative changes in rat brain, lung, liver, kidney and testes tissues. Rats were divided into four groups as control (C); RVT (30 mg/kg i.p. dissolved in 0.9% NaCl), ACR (40 mg/kg i.p.) and RVT + ACR groups. After 10 days rats were decapitated and tissues were excised. 8-hydroxydeoxyguanosine (8-OHdG) is a biomarker of oxidative DNA damage. 8-OHdG content in the extracted DNA solution was determined by enzyme-linked immunosorbent assay method. Malondialdehyde (MDA), glutathione (GSH) levels and myeloperoxidase activity (MPO) were determined in tissues, while oxidant-induced tissue fibrosis was determined by collagen contents. Serum enzyme activities, cytokine levels, leukocyte apoptosis were assayed in plasma. As an indicator of oxidative DNA damage, 8-OHdG levels significantly increased in ACR group and this was reversed significantly by RVT treatment. In ACR group, GSH levels decreased significantly while the MDA levels, MPO activity and collagen content increased in the tissues suggesting oxidative organ damage. In RVT-treated ACR group, oxidant responses reversed significantly. Serum enzyme activities, cytokine levels and leukocyte late apoptosis which increased following ACR administration, decreased with RVT treatment. Therefore supplementing with RVT can be useful in individuals at risk of ACR toxicity.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>21947844</pmid><doi>10.1007/s11033-011-1249-5</doi><tpages>8</tpages></addata></record> |
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| ispartof | Molecular biology reports, 2012-04, Vol.39 (4), p.4589-4596 |
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| subjects | Acrylamide - toxicity Alanine Transaminase - blood Animal Anatomy Animal Biochemistry Animals Apoptosis Apoptosis - drug effects Aspartate Aminotransferases - blood Biomarkers Biomedical and Life Sciences Blood Urea Nitrogen Creatinine - blood Cytokines - blood Deoxyguanosine - analogs & derivatives Deoxyguanosine - blood DNA Damage Female Glutathione - metabolism Histology Humans L-Lactate Dehydrogenase - blood Leukocytes Life Sciences Lymphocytes - drug effects Lymphocytes - pathology Male Malondialdehyde - metabolism Morphology Neutrophils - drug effects Neutrophils - pathology Oxidative stress Oxidative Stress - drug effects Peroxidase - metabolism Protective Agents - pharmacology Rats Rats, Wistar Rodents Stilbenes - pharmacology |
| title | Resveratrol ameliorates oxidative DNA damage and protects against acrylamide-induced oxidative stress in rats |
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