Propylthiouracil-induced autoimmune syndromes: 11 case report
The objective of this study was to report 11 cases of propylthiouracil (PTU)-induced autoimmune syndromes. We describe the clinical presentation, course, and outcome of 11 patients and compare clinical features between PTU-induced lupus and PTU-induced vasculitis. Of our 11 patients, 7 patients had...
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| Veröffentlicht in: | Rheumatology international 2012-03, Vol.32 (3), p.679-681 |
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| creator | Wu, Rui Li, Rongheng |
| description | The objective of this study was to report 11 cases of propylthiouracil (PTU)-induced autoimmune syndromes. We describe the clinical presentation, course, and outcome of 11 patients and compare clinical features between PTU-induced lupus and PTU-induced vasculitis. Of our 11 patients, 7 patients had vasculitis and 4 patients had lupus. Patients with vasculitis were olderand had a longer duration of treatment in comparison with lupus. P-ANCA were predominantly found in PTU-induced vasculitis, but also found in lupus, while ANA and anti-dsDNA were often found in lupus. Some difference of renal and pulmonary involvement was often found between PTU-induced vasculitis and lupus. Most of patients needed steroids or immunosuppressive drugs. Vasculitis in the cases of PTU-induced autoimmune phenomena is often found than lupus. P-ANCA in both PTU-induced lupus and vasculitis can all present, but there are differences in clinical and outcome features to diagnosis. |
| doi_str_mv | 10.1007/s00296-010-1675-z |
| format | Article |
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We describe the clinical presentation, course, and outcome of 11 patients and compare clinical features between PTU-induced lupus and PTU-induced vasculitis. Of our 11 patients, 7 patients had vasculitis and 4 patients had lupus. Patients with vasculitis were olderand had a longer duration of treatment in comparison with lupus. P-ANCA were predominantly found in PTU-induced vasculitis, but also found in lupus, while ANA and anti-dsDNA were often found in lupus. Some difference of renal and pulmonary involvement was often found between PTU-induced vasculitis and lupus. Most of patients needed steroids or immunosuppressive drugs. Vasculitis in the cases of PTU-induced autoimmune phenomena is often found than lupus. P-ANCA in both PTU-induced lupus and vasculitis can all present, but there are differences in clinical and outcome features to diagnosis.</description><identifier>ISSN: 0172-8172</identifier><identifier>EISSN: 1437-160X</identifier><identifier>DOI: 10.1007/s00296-010-1675-z</identifier><identifier>PMID: 21136260</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Antibodies, Antineutrophil Cytoplasmic - blood ; Antithyroid Agents - adverse effects ; Drug Therapy, Combination ; Female ; Glucocorticoids - therapeutic use ; Humans ; Immunosuppressive Agents - therapeutic use ; Kidney - drug effects ; Kidney - pathology ; Lung - drug effects ; Lung - pathology ; Lupus Erythematosus, Systemic - chemically induced ; Lupus Erythematosus, Systemic - drug therapy ; Lupus Erythematosus, Systemic - pathology ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Propylthiouracil - adverse effects ; Rheumatology ; Therapeutics ; Treatment Outcome ; Vasculitis - chemically induced ; Vasculitis - drug therapy ; Vasculitis - pathology ; Young Adult</subject><ispartof>Rheumatology international, 2012-03, Vol.32 (3), p.679-681</ispartof><rights>Springer-Verlag 2010</rights><rights>Springer-Verlag 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-adcd16348996c1542c501785f976f7ccd0def8c2cc4a90fbd377417ebe511b183</citedby><cites>FETCH-LOGICAL-c436t-adcd16348996c1542c501785f976f7ccd0def8c2cc4a90fbd377417ebe511b183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00296-010-1675-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00296-010-1675-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21136260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Rui</creatorcontrib><creatorcontrib>Li, Rongheng</creatorcontrib><title>Propylthiouracil-induced autoimmune syndromes: 11 case report</title><title>Rheumatology international</title><addtitle>Rheumatol Int</addtitle><addtitle>Rheumatol Int</addtitle><description>The objective of this study was to report 11 cases of propylthiouracil (PTU)-induced autoimmune syndromes. We describe the clinical presentation, course, and outcome of 11 patients and compare clinical features between PTU-induced lupus and PTU-induced vasculitis. Of our 11 patients, 7 patients had vasculitis and 4 patients had lupus. Patients with vasculitis were olderand had a longer duration of treatment in comparison with lupus. P-ANCA were predominantly found in PTU-induced vasculitis, but also found in lupus, while ANA and anti-dsDNA were often found in lupus. Some difference of renal and pulmonary involvement was often found between PTU-induced vasculitis and lupus. Most of patients needed steroids or immunosuppressive drugs. Vasculitis in the cases of PTU-induced autoimmune phenomena is often found than lupus. P-ANCA in both PTU-induced lupus and vasculitis can all present, but there are differences in clinical and outcome features to diagnosis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Antibodies, Antineutrophil Cytoplasmic - blood</subject><subject>Antithyroid Agents - adverse effects</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Kidney - drug effects</subject><subject>Kidney - pathology</subject><subject>Lung - drug effects</subject><subject>Lung - pathology</subject><subject>Lupus Erythematosus, Systemic - chemically induced</subject><subject>Lupus Erythematosus, Systemic - drug therapy</subject><subject>Lupus Erythematosus, Systemic - pathology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Propylthiouracil - adverse effects</subject><subject>Rheumatology</subject><subject>Therapeutics</subject><subject>Treatment Outcome</subject><subject>Vasculitis - chemically induced</subject><subject>Vasculitis - drug therapy</subject><subject>Vasculitis - pathology</subject><subject>Young Adult</subject><issn>0172-8172</issn><issn>1437-160X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1UMtOwzAQtBCIlsIHcEERd8Ou49gJEgdU8ZIqwQEkblZiO5CqeWAnh_br6yoFTlx2NdrZmdEQco5whQDy2gOwTFBAoChkQjcHZIo8lgHBxyGZAkpG0zAm5MT7JQQsBByTCUOMBRMwJbevru3Wq_6rageX62pFq8YM2pooH_q2quuhsZFfN8a1tfU3EWKkc28jZ7vW9afkqMxX3p7t94y8P9y_zZ_o4uXxeX63oJrHoqe50QZFzNMsExoTznQSoqRJmUlRSq0NGFummmnN8wzKwsRScpS2sAligWk8I5ejbufa78H6Xi1D3CZYqowlMsl4zAMJR5J2rffOlqpzVZ27tUJQu77U2JeCHQ59qU34udgLD0Vtze_HT0GBwEaCD6fm07o_5_9VtyYedgU</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Wu, Rui</creator><creator>Li, Rongheng</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20120301</creationdate><title>Propylthiouracil-induced autoimmune syndromes: 11 case report</title><author>Wu, Rui ; Li, Rongheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-adcd16348996c1542c501785f976f7ccd0def8c2cc4a90fbd377417ebe511b183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Antibodies, Antineutrophil Cytoplasmic - blood</topic><topic>Antithyroid Agents - adverse effects</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Kidney - drug effects</topic><topic>Kidney - pathology</topic><topic>Lung - drug effects</topic><topic>Lung - pathology</topic><topic>Lupus Erythematosus, Systemic - chemically induced</topic><topic>Lupus Erythematosus, Systemic - drug therapy</topic><topic>Lupus Erythematosus, Systemic - pathology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Propylthiouracil - adverse effects</topic><topic>Rheumatology</topic><topic>Therapeutics</topic><topic>Treatment Outcome</topic><topic>Vasculitis - chemically induced</topic><topic>Vasculitis - drug therapy</topic><topic>Vasculitis - pathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Rui</creatorcontrib><creatorcontrib>Li, Rongheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Rheumatology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Rui</au><au>Li, Rongheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Propylthiouracil-induced autoimmune syndromes: 11 case report</atitle><jtitle>Rheumatology international</jtitle><stitle>Rheumatol Int</stitle><addtitle>Rheumatol Int</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>32</volume><issue>3</issue><spage>679</spage><epage>681</epage><pages>679-681</pages><issn>0172-8172</issn><eissn>1437-160X</eissn><abstract>The objective of this study was to report 11 cases of propylthiouracil (PTU)-induced autoimmune syndromes. We describe the clinical presentation, course, and outcome of 11 patients and compare clinical features between PTU-induced lupus and PTU-induced vasculitis. Of our 11 patients, 7 patients had vasculitis and 4 patients had lupus. Patients with vasculitis were olderand had a longer duration of treatment in comparison with lupus. P-ANCA were predominantly found in PTU-induced vasculitis, but also found in lupus, while ANA and anti-dsDNA were often found in lupus. Some difference of renal and pulmonary involvement was often found between PTU-induced vasculitis and lupus. Most of patients needed steroids or immunosuppressive drugs. Vasculitis in the cases of PTU-induced autoimmune phenomena is often found than lupus. P-ANCA in both PTU-induced lupus and vasculitis can all present, but there are differences in clinical and outcome features to diagnosis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21136260</pmid><doi>10.1007/s00296-010-1675-z</doi><tpages>3</tpages></addata></record> |
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| subjects | Adolescent Adult Age Factors Aged Antibodies, Antineutrophil Cytoplasmic - blood Antithyroid Agents - adverse effects Drug Therapy, Combination Female Glucocorticoids - therapeutic use Humans Immunosuppressive Agents - therapeutic use Kidney - drug effects Kidney - pathology Lung - drug effects Lung - pathology Lupus Erythematosus, Systemic - chemically induced Lupus Erythematosus, Systemic - drug therapy Lupus Erythematosus, Systemic - pathology Medicine Medicine & Public Health Middle Aged Original Article Propylthiouracil - adverse effects Rheumatology Therapeutics Treatment Outcome Vasculitis - chemically induced Vasculitis - drug therapy Vasculitis - pathology Young Adult |
| title | Propylthiouracil-induced autoimmune syndromes: 11 case report |
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