Feasibility of biweekly combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in patients with metastatic solid tumors: results of a two-step phase I trial: XELIRI and XELIRINOX

Background Biweekly schedule of capecitabine combined with irinotecan (XELIRI), consecutively with irinotecan and oxaliplatin (XELIRINOX), was evaluated in patients with metastatic cancer from any solid tumors. Patients and methods In this two-step phase I trial, seventeen and eleven patients were e...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2012-03, Vol.69 (3), p.807-814
Hauptverfasser:	Mazard, T., Ychou, M., Thezenas, S., Poujol, S., Pinguet, F., Thirion, A., Bleuse, J. P., Portales, F., Samalin, E., Assenat, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Camptothecin - administration & dosage Camptothecin - adverse effects Camptothecin - analogs & derivatives Camptothecin - pharmacokinetics Camptothecin - therapeutic use Cancer Research Capecitabine Chromatography, High Pressure Liquid Deoxycytidine - administration & dosage Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacokinetics Deoxycytidine - therapeutic use Dose-Response Relationship, Drug Drug Administration Schedule Feasibility Studies Female Fluorouracil - administration & dosage Fluorouracil - adverse effects Fluorouracil - analogs & derivatives Fluorouracil - pharmacokinetics Fluorouracil - therapeutic use Gastroenterology. Liver. Pancreas. Abdomen Glucuronosyltransferase - genetics Humans Male Maximum Tolerated Dose Medical sciences Medicine Medicine & Public Health Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Mutation Neoplasm Metastasis Neoplasms - drug therapy Neoplasms - genetics Neoplasms - pathology Oncology Organoplatinum Compounds - administration & dosage Organoplatinum Compounds - adverse effects Organoplatinum Compounds - pharmacokinetics Organoplatinum Compounds - therapeutic use Original Article Pharmacology. Drug treatments Pharmacology/Toxicology Prospective Studies Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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