Accurate measurement of total attenuation coefficient of thin tissue with optical coherence tomography
Noninvasive accurate measurements of tissue optical properties are needed for many diagnostic and therapeutic applications. Optical coherence tomography (OCT) recently proposed for high-resolution imaging in tissue can potentially be applied for accurate, noninvasive, and high-resolution measurement...
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| Veröffentlicht in: | IEEE journal of selected topics in quantum electronics 2003-03, Vol.9 (2), p.210-221 |
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| creator | Kholodnykh, A.I. Petrova, I.Y. Motamedi, M. Esenaliev, R.O. |
| description | Noninvasive accurate measurements of tissue optical properties are needed for many diagnostic and therapeutic applications. Optical coherence tomography (OCT) recently proposed for high-resolution imaging in tissue can potentially be applied for accurate, noninvasive, and high-resolution measurement of tissue total attenuation coefficient. However, confocal function (dependence of OCT sensitivity on the distance of probed site from the focal plane of the objective lens) and multiple scattering substantially limit the accuracy of the measurement with the OCT technique. We studied the influence of the confocal function and multiple scattering on the accuracy of the measurement and proposed methods that provide measurement of the total attenuation coefficient with a significantly reduced systematic error. Experiments were performed in tissue phantoms and porcine and human skin in vitro and in vivo. Our data indicate that the tissue total attenuation coefficient can noninvasively be measured in vivo with the accuracy of 5%-10% in the range from 0.5 to 17 mm/sup -1/ and about 20% in the range up to 40 mm/sup -1/. These results suggest that the proper correction of the OCT-based measurement for the confocal function and multiple scattering provides absolute values of tissue total attenuation coefficient with high accuracy and resolution that may not be achievable by other optical techniques in vivo. |
| doi_str_mv | 10.1109/JSTQE.2003.814194 |
| format | Article |
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Optical coherence tomography (OCT) recently proposed for high-resolution imaging in tissue can potentially be applied for accurate, noninvasive, and high-resolution measurement of tissue total attenuation coefficient. However, confocal function (dependence of OCT sensitivity on the distance of probed site from the focal plane of the objective lens) and multiple scattering substantially limit the accuracy of the measurement with the OCT technique. We studied the influence of the confocal function and multiple scattering on the accuracy of the measurement and proposed methods that provide measurement of the total attenuation coefficient with a significantly reduced systematic error. Experiments were performed in tissue phantoms and porcine and human skin in vitro and in vivo. Our data indicate that the tissue total attenuation coefficient can noninvasively be measured in vivo with the accuracy of 5%-10% in the range from 0.5 to 17 mm/sup -1/ and about 20% in the range up to 40 mm/sup -1/. These results suggest that the proper correction of the OCT-based measurement for the confocal function and multiple scattering provides absolute values of tissue total attenuation coefficient with high accuracy and resolution that may not be achievable by other optical techniques in vivo.</description><identifier>ISSN: 1077-260X</identifier><identifier>EISSN: 1558-4542</identifier><identifier>DOI: 10.1109/JSTQE.2003.814194</identifier><identifier>CODEN: IJSQEN</identifier><language>eng</language><publisher>New York: IEEE</publisher><subject>Accuracy ; Attenuation coefficients ; Attenuation measurement ; Biocompatibility ; Biomedical materials ; Confocal ; High-resolution imaging ; Humans ; Imaging phantoms ; In vivo ; In vivo testing ; In vivo tests ; Lenses ; Optical attenuators ; Optical scattering ; Optical sensors ; Scattering ; Studies ; Surgical implants ; Tomography</subject><ispartof>IEEE journal of selected topics in quantum electronics, 2003-03, Vol.9 (2), p.210-221</ispartof><rights>Copyright The Institute of Electrical and Electronics Engineers, Inc. (IEEE) 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-316d5eb52c4bb20d931d7e1c6d1e86985aba553293d951929764c328969f71b23</citedby><cites>FETCH-LOGICAL-c354t-316d5eb52c4bb20d931d7e1c6d1e86985aba553293d951929764c328969f71b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/1238980$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>314,776,780,792,27901,27902,54733</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/1238980$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc></links><search><creatorcontrib>Kholodnykh, A.I.</creatorcontrib><creatorcontrib>Petrova, I.Y.</creatorcontrib><creatorcontrib>Motamedi, M.</creatorcontrib><creatorcontrib>Esenaliev, R.O.</creatorcontrib><title>Accurate measurement of total attenuation coefficient of thin tissue with optical coherence tomography</title><title>IEEE journal of selected topics in quantum electronics</title><addtitle>JSTQE</addtitle><description>Noninvasive accurate measurements of tissue optical properties are needed for many diagnostic and therapeutic applications. Optical coherence tomography (OCT) recently proposed for high-resolution imaging in tissue can potentially be applied for accurate, noninvasive, and high-resolution measurement of tissue total attenuation coefficient. However, confocal function (dependence of OCT sensitivity on the distance of probed site from the focal plane of the objective lens) and multiple scattering substantially limit the accuracy of the measurement with the OCT technique. We studied the influence of the confocal function and multiple scattering on the accuracy of the measurement and proposed methods that provide measurement of the total attenuation coefficient with a significantly reduced systematic error. Experiments were performed in tissue phantoms and porcine and human skin in vitro and in vivo. Our data indicate that the tissue total attenuation coefficient can noninvasively be measured in vivo with the accuracy of 5%-10% in the range from 0.5 to 17 mm/sup -1/ and about 20% in the range up to 40 mm/sup -1/. These results suggest that the proper correction of the OCT-based measurement for the confocal function and multiple scattering provides absolute values of tissue total attenuation coefficient with high accuracy and resolution that may not be achievable by other optical techniques in vivo.</description><subject>Accuracy</subject><subject>Attenuation coefficients</subject><subject>Attenuation measurement</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Confocal</subject><subject>High-resolution imaging</subject><subject>Humans</subject><subject>Imaging phantoms</subject><subject>In vivo</subject><subject>In vivo testing</subject><subject>In vivo tests</subject><subject>Lenses</subject><subject>Optical attenuators</subject><subject>Optical scattering</subject><subject>Optical sensors</subject><subject>Scattering</subject><subject>Studies</subject><subject>Surgical implants</subject><subject>Tomography</subject><issn>1077-260X</issn><issn>1558-4542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>RIE</sourceid><recordid>eNp9kU1rGzEQhkVJoY7TH1B6WXIovayj0ceudDQmaRICIcSF3oRWO1vLeFeOpCX433cTtwR6yGnm8LzvMDyEfAG6AKD64vZx_XC5YJTyhQIBWnwgM5BSlUIKdjLttK5LVtFfn8hpSltKqRKKzki3dG6MNmPRo01jxB6HXISuyCHbXWFzxmG02YehcAG7zjv_D9j4ocg-pRGLZ583Rdhn76aMCxuMODicOvrwO9r95nBGPnZ2l_Dz3zknP68u16vr8u7-x81qeVc6LkUuOVStxEYyJ5qG0VZzaGsEV7WAqtJK2sZKyZnmrZagma4r4ThTutJdDQ3jc_Lt2LuP4WnElE3vk8Pdzg4YxmSYAg2C1hP4_V0QqhqYZnQ6NSfn_6HbMMZhesNoxrSsJRcTBEfIxZBSxM7so-9tPBig5sWQeTVkXgyZo6Ep8_WY8Yj4xjOutKL8DwIEjTo</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>Kholodnykh, A.I.</creator><creator>Petrova, I.Y.</creator><creator>Motamedi, M.</creator><creator>Esenaliev, R.O.</creator><general>IEEE</general><general>The Institute of Electrical and Electronics Engineers, Inc. (IEEE)</general><scope>RIA</scope><scope>RIE</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>F28</scope><scope>FR3</scope></search><sort><creationdate>20030301</creationdate><title>Accurate measurement of total attenuation coefficient of thin tissue with optical coherence tomography</title><author>Kholodnykh, A.I. ; Petrova, I.Y. ; Motamedi, M. ; Esenaliev, R.O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-316d5eb52c4bb20d931d7e1c6d1e86985aba553293d951929764c328969f71b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Accuracy</topic><topic>Attenuation coefficients</topic><topic>Attenuation measurement</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Confocal</topic><topic>High-resolution imaging</topic><topic>Humans</topic><topic>Imaging phantoms</topic><topic>In vivo</topic><topic>In vivo testing</topic><topic>In vivo tests</topic><topic>Lenses</topic><topic>Optical attenuators</topic><topic>Optical scattering</topic><topic>Optical sensors</topic><topic>Scattering</topic><topic>Studies</topic><topic>Surgical implants</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kholodnykh, A.I.</creatorcontrib><creatorcontrib>Petrova, I.Y.</creatorcontrib><creatorcontrib>Motamedi, M.</creatorcontrib><creatorcontrib>Esenaliev, R.O.</creatorcontrib><collection>IEEE All-Society Periodicals Package (ASPP) 1998-Present</collection><collection>IEEE Electronic Library (IEL)</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><jtitle>IEEE journal of selected topics in quantum electronics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Kholodnykh, A.I.</au><au>Petrova, I.Y.</au><au>Motamedi, M.</au><au>Esenaliev, R.O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Accurate measurement of total attenuation coefficient of thin tissue with optical coherence tomography</atitle><jtitle>IEEE journal of selected topics in quantum electronics</jtitle><stitle>JSTQE</stitle><date>2003-03-01</date><risdate>2003</risdate><volume>9</volume><issue>2</issue><spage>210</spage><epage>221</epage><pages>210-221</pages><issn>1077-260X</issn><eissn>1558-4542</eissn><coden>IJSQEN</coden><abstract>Noninvasive accurate measurements of tissue optical properties are needed for many diagnostic and therapeutic applications. Optical coherence tomography (OCT) recently proposed for high-resolution imaging in tissue can potentially be applied for accurate, noninvasive, and high-resolution measurement of tissue total attenuation coefficient. However, confocal function (dependence of OCT sensitivity on the distance of probed site from the focal plane of the objective lens) and multiple scattering substantially limit the accuracy of the measurement with the OCT technique. We studied the influence of the confocal function and multiple scattering on the accuracy of the measurement and proposed methods that provide measurement of the total attenuation coefficient with a significantly reduced systematic error. Experiments were performed in tissue phantoms and porcine and human skin in vitro and in vivo. Our data indicate that the tissue total attenuation coefficient can noninvasively be measured in vivo with the accuracy of 5%-10% in the range from 0.5 to 17 mm/sup -1/ and about 20% in the range up to 40 mm/sup -1/. These results suggest that the proper correction of the OCT-based measurement for the confocal function and multiple scattering provides absolute values of tissue total attenuation coefficient with high accuracy and resolution that may not be achievable by other optical techniques in vivo.</abstract><cop>New York</cop><pub>IEEE</pub><doi>10.1109/JSTQE.2003.814194</doi><tpages>12</tpages></addata></record> |
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| subjects | Accuracy Attenuation coefficients Attenuation measurement Biocompatibility Biomedical materials Confocal High-resolution imaging Humans Imaging phantoms In vivo In vivo testing In vivo tests Lenses Optical attenuators Optical scattering Optical sensors Scattering Studies Surgical implants Tomography |
| title | Accurate measurement of total attenuation coefficient of thin tissue with optical coherence tomography |
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