Pleural Fluid Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Complicated and Uncomplicated Parapneumonic Pleural Effusions
Background. Soluble triggering receptor expressed on myeoid cells-1 (sTREM-1) has recently been found to be high in infected pleural fluid (PF). Objectives. Diagnostic accuracy of PF sTREM-1 for differentiating uncomplicated parapneumonic effusions (UPPEs) from complicated parapneumonic effusions (C...
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| Veröffentlicht in: | ISRN pulmonology 2011-01, Vol.2011 (2011), p.1-6 |
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| creator | Bediwy, Adel Salah Elkholy, Mohamed Gamal A. Elbedewy, Mohamed Mohamed Hasanein, Mohamed A. |
| description | Background. Soluble triggering receptor expressed on myeoid cells-1 (sTREM-1) has recently been found to be high in infected pleural fluid (PF). Objectives. Diagnostic accuracy of PF sTREM-1 for differentiating uncomplicated parapneumonic effusions (UPPEs) from complicated parapneumonic effusions (CPPEs) was evaluated prospectively. Methods. Serum and PF sTREM-1 were measured for 68 patients with parapneumonic and transudative pleural effusion. Results. PF (but not serum) sTREM-1 concentrations were significantly higher in CPPE than in UPPE. Serum and PF sTREM-1 levels were higher in parapneumonic than in transudative groups. PF sTREM-1 had a sensitivity of 85.19% and a specificity of 83.33% at cutoff value of 250.5 pg/mL for differentiating CPPE and UPPE with area under the curve (AUC) of 0.9336. After excluding purulent CPPE cases, sensitivity and specificity became 90.48% and 83.33%, respectively (at the same cutoff value) with AUC of 0.9444. Conclusion. High concentrations of PF sTREM-1 (above 250.5 pg/mL) help to early diagnose and differentiate CPPE from UPPE. |
| doi_str_mv | 10.5402/2011/716486 |
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L.</contributor><creatorcontrib>Bediwy, Adel Salah ; Elkholy, Mohamed Gamal A. ; Elbedewy, Mohamed Mohamed ; Hasanein, Mohamed A. ; Metersky, M. L.</creatorcontrib><description>Background. Soluble triggering receptor expressed on myeoid cells-1 (sTREM-1) has recently been found to be high in infected pleural fluid (PF). Objectives. Diagnostic accuracy of PF sTREM-1 for differentiating uncomplicated parapneumonic effusions (UPPEs) from complicated parapneumonic effusions (CPPEs) was evaluated prospectively. Methods. Serum and PF sTREM-1 were measured for 68 patients with parapneumonic and transudative pleural effusion. Results. PF (but not serum) sTREM-1 concentrations were significantly higher in CPPE than in UPPE. Serum and PF sTREM-1 levels were higher in parapneumonic than in transudative groups. PF sTREM-1 had a sensitivity of 85.19% and a specificity of 83.33% at cutoff value of 250.5 pg/mL for differentiating CPPE and UPPE with area under the curve (AUC) of 0.9336. After excluding purulent CPPE cases, sensitivity and specificity became 90.48% and 83.33%, respectively (at the same cutoff value) with AUC of 0.9444. Conclusion. High concentrations of PF sTREM-1 (above 250.5 pg/mL) help to early diagnose and differentiate CPPE from UPPE.</description><identifier>ISSN: 2090-5769</identifier><identifier>EISSN: 2090-5777</identifier><identifier>DOI: 10.5402/2011/716486</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Glucose ; Lungs ; Medical diagnosis ; Medicine ; Mortality ; Pneumonia ; Signal transduction ; Studies</subject><ispartof>ISRN pulmonology, 2011-01, Vol.2011 (2011), p.1-6</ispartof><rights>Copyright © 2011 Adel Salah Bediwy et al.</rights><rights>Copyright © 2011 Adel Salah Bediwy et al. Adel Salah Bediwy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1576-843cb0694da5bc49ad5814c0b89f79cb398221678c1c7f8b383abcab13dd50a83</cites><orcidid>0000-0002-0281-0010</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><contributor>Metersky, M. 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Serum and PF sTREM-1 levels were higher in parapneumonic than in transudative groups. PF sTREM-1 had a sensitivity of 85.19% and a specificity of 83.33% at cutoff value of 250.5 pg/mL for differentiating CPPE and UPPE with area under the curve (AUC) of 0.9336. After excluding purulent CPPE cases, sensitivity and specificity became 90.48% and 83.33%, respectively (at the same cutoff value) with AUC of 0.9444. Conclusion. High concentrations of PF sTREM-1 (above 250.5 pg/mL) help to early diagnose and differentiate CPPE from UPPE.</description><subject>Glucose</subject><subject>Lungs</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Mortality</subject><subject>Pneumonia</subject><subject>Signal transduction</subject><subject>Studies</subject><issn>2090-5769</issn><issn>2090-5777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0EFLwzAUB_AiCo7pybMQPCp1SZo2yVHGpsLEodu5pGk6M7KkJiu6T-DXNqM6vJnLC4_fyyP_JLlA8DYnEI8wRGhEUUFYcZQMMOQwzSmlx4d7wU-T8xDWMJ4CYoL4IPmaG9V5YcDUdLoGr850lVFg4fVqpby2K_CipGq3zoPJZ-tVCKoGzoKnnTIuDoyVMSFFQFswdpvWaCm2UQhbg6WVfzpz4UVrVbdxVkvwu3XSNF3Qzoaz5KQRJqjznzpMltPJYvyQzp7vH8d3s1Si-IGUkUxWsOCkFnklCRd1zhCRsGK8oVxWGWcYo4IyiSRtWJWxTFRSVCir6xwKlg2Tq_7d1rv3ToVtuXadt3FlyTFmhNEcR3TTI-ldCF41Zev1RvhdiWC5z7rcZ132WUd93es3bWvxof_Blz1WkahGHDDhmKMs-wYWO4jl</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Bediwy, Adel Salah</creator><creator>Elkholy, Mohamed Gamal A.</creator><creator>Elbedewy, Mohamed Mohamed</creator><creator>Hasanein, Mohamed A.</creator><general>Hindawi Puplishing Corporation</general><general>International Scholarly Research Network</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0002-0281-0010</orcidid></search><sort><creationdate>20110101</creationdate><title>Pleural Fluid Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Complicated and Uncomplicated Parapneumonic Pleural Effusions</title><author>Bediwy, Adel Salah ; Elkholy, Mohamed Gamal A. ; Elbedewy, Mohamed Mohamed ; Hasanein, Mohamed A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1576-843cb0694da5bc49ad5814c0b89f79cb398221678c1c7f8b383abcab13dd50a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Glucose</topic><topic>Lungs</topic><topic>Medical diagnosis</topic><topic>Medicine</topic><topic>Mortality</topic><topic>Pneumonia</topic><topic>Signal transduction</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bediwy, Adel Salah</creatorcontrib><creatorcontrib>Elkholy, Mohamed Gamal A.</creatorcontrib><creatorcontrib>Elbedewy, Mohamed Mohamed</creatorcontrib><creatorcontrib>Hasanein, Mohamed A.</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>ISRN pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bediwy, Adel Salah</au><au>Elkholy, Mohamed Gamal A.</au><au>Elbedewy, Mohamed Mohamed</au><au>Hasanein, Mohamed A.</au><au>Metersky, M. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pleural Fluid Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Complicated and Uncomplicated Parapneumonic Pleural Effusions</atitle><jtitle>ISRN pulmonology</jtitle><date>2011-01-01</date><risdate>2011</risdate><volume>2011</volume><issue>2011</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>2090-5769</issn><eissn>2090-5777</eissn><abstract>Background. Soluble triggering receptor expressed on myeoid cells-1 (sTREM-1) has recently been found to be high in infected pleural fluid (PF). Objectives. Diagnostic accuracy of PF sTREM-1 for differentiating uncomplicated parapneumonic effusions (UPPEs) from complicated parapneumonic effusions (CPPEs) was evaluated prospectively. Methods. Serum and PF sTREM-1 were measured for 68 patients with parapneumonic and transudative pleural effusion. Results. PF (but not serum) sTREM-1 concentrations were significantly higher in CPPE than in UPPE. Serum and PF sTREM-1 levels were higher in parapneumonic than in transudative groups. PF sTREM-1 had a sensitivity of 85.19% and a specificity of 83.33% at cutoff value of 250.5 pg/mL for differentiating CPPE and UPPE with area under the curve (AUC) of 0.9336. After excluding purulent CPPE cases, sensitivity and specificity became 90.48% and 83.33%, respectively (at the same cutoff value) with AUC of 0.9444. Conclusion. High concentrations of PF sTREM-1 (above 250.5 pg/mL) help to early diagnose and differentiate CPPE from UPPE.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><doi>10.5402/2011/716486</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-0281-0010</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Glucose Lungs Medical diagnosis Medicine Mortality Pneumonia Signal transduction Studies |
| title | Pleural Fluid Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Complicated and Uncomplicated Parapneumonic Pleural Effusions |
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