Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1

The G protein-coupled free fatty acid receptor-1 (FFA1/GPR40) plays a major role in the regulation of insulin secretion by fatty acids. GPR40 is considered a potential therapeutic target to enhance insulin secretion in type 2 diabetes; however, its mode of regulation is essentially unknown. The aims...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-02, Vol.109 (7), p.2376-2381
Hauptverfasser:	Kebede, Melkam, Ferdaoussi, Mourad, Mancini, Arturo, Alquier, Thierry, Kulkarni, Rohit N, Walker, Michael D, Poitout, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Acetylglucosamine - metabolism Animals Beta cells binding sites Biological Sciences biosynthesis Diabetes mellitus Duodenum - metabolism Fatty acids free fatty acids Gene expression Glucosamine Glucose Glucose - metabolism Hexosamines - biosynthesis Homeodomain Proteins - metabolism Humans Insulin Insulin - metabolism Insulin Secretion islets of Langerhans Mice Mice, Inbred C57BL Mutation noninsulin-dependent diabetes mellitus nuclear membrane Nuclear membranes nuclear proteins Nuclei Pancreas Pancreas - metabolism phosphatidylinositol 3,4,5-triphosphate phosphatidylinositol 3-kinase Phosphatidylinositol 3-Kinases - metabolism Promoters Proteins Receptors, G-Protein-Coupled - genetics Secretion Signal transduction Transcription transcription (genetics) Transcription factors Transcription, Genetic
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