Comparison of Histological Measures of Skin Photoaging
Background: Dermal elastosis is considered the histological ‘gold standard’ for evaluation of skin photoaging, but the relation of the level of dermal elastosis to other histological indicators of photoaging is not clear. Objective: To investigate how various proposed histological measures of photoa...
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| Veröffentlicht in: | Dermatology (Basel) 2011-01, Vol.223 (2), p.140-151 |
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| creator | Hughes, M.C. Bredoux, C. Salas, F. Lombard, D. Strutton, G.M. Fourtanier, A. Green, A.C. |
| description | Background: Dermal elastosis is considered the histological ‘gold standard’ for evaluation of skin photoaging, but the relation of the level of dermal elastosis to other histological indicators of photoaging is not clear. Objective: To investigate how various proposed histological measures of photoaging compare with the level of dermal elastosis. Methods: Prospective, community-based study in Southeast Queensland, Australia, among 89 participants aged 40–82 years. Quantitative histology was used to evaluate 8 biomarkers of photoaged skin, and associations between grades of dermal elastosis and each of the other 7 biomarkers were analysed using ordinal logistic regression models with proportional odds assumption, using histological grades of elastosis as the outcome. Results: Older age, male sex and high outdoor exposure levels were confirmed as predictors ofhigh levels of dermal elastosis. After adjustment for age and sex, the only significant positive association with increasing elastosis grades was the proportion of p53-positive cells. Epidermal thickness, interdigitation index proportion of surface covered with melanin (% Fontana-Masson staining) and glycosaminoglycan content were not associated with elastosis in either crude or adjusted models. Conclusions: Amonga range of suggested biomarkers of photoaged skin, only p53-positive cells appear to be strongly associated with the level of dermal elastosis. |
| doi_str_mv | 10.1159/000332425 |
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Objective: To investigate how various proposed histological measures of photoaging compare with the level of dermal elastosis. Methods: Prospective, community-based study in Southeast Queensland, Australia, among 89 participants aged 40–82 years. Quantitative histology was used to evaluate 8 biomarkers of photoaged skin, and associations between grades of dermal elastosis and each of the other 7 biomarkers were analysed using ordinal logistic regression models with proportional odds assumption, using histological grades of elastosis as the outcome. Results: Older age, male sex and high outdoor exposure levels were confirmed as predictors ofhigh levels of dermal elastosis. After adjustment for age and sex, the only significant positive association with increasing elastosis grades was the proportion of p53-positive cells. Epidermal thickness, interdigitation index proportion of surface covered with melanin (% Fontana-Masson staining) and glycosaminoglycan content were not associated with elastosis in either crude or adjusted models. Conclusions: Amonga range of suggested biomarkers of photoaged skin, only p53-positive cells appear to be strongly associated with the level of dermal elastosis.</description><identifier>ISSN: 1018-8665</identifier><identifier>EISSN: 1421-9832</identifier><identifier>DOI: 10.1159/000332425</identifier><identifier>PMID: 21997520</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Aging ; Biological and medical sciences ; Biomarkers ; Dermatology ; Dermis - chemistry ; Dermis - pathology ; Elastic Tissue - pathology ; Epidermis - chemistry ; Epidermis - pathology ; Female ; Glycosaminoglycans ; Histology ; Humans ; Immunohistochemistry ; Logistic Models ; Male ; Medical sciences ; Melanins ; Middle Aged ; Original Paper ; Queensland ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Sex Factors ; Skin ; Skin Aging - pathology ; Sunlight - adverse effects ; Tumor Suppressor Protein p53 ; Ultraviolet radiation</subject><ispartof>Dermatology (Basel), 2011-01, Vol.223 (2), p.140-151</ispartof><rights>2011 S. Karger AG, Basel</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 S. Karger AG, Basel.</rights><rights>Copyright (c) 2011 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-6ee5b173330c4b5a03437c994b797ec1fb3230931f94313819378fd8a1a9d1763</citedby><cites>FETCH-LOGICAL-c362t-6ee5b173330c4b5a03437c994b797ec1fb3230931f94313819378fd8a1a9d1763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25232358$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21997520$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hughes, M.C.</creatorcontrib><creatorcontrib>Bredoux, C.</creatorcontrib><creatorcontrib>Salas, F.</creatorcontrib><creatorcontrib>Lombard, D.</creatorcontrib><creatorcontrib>Strutton, G.M.</creatorcontrib><creatorcontrib>Fourtanier, A.</creatorcontrib><creatorcontrib>Green, A.C.</creatorcontrib><title>Comparison of Histological Measures of Skin Photoaging</title><title>Dermatology (Basel)</title><addtitle>Dermatology</addtitle><description>Background: Dermal elastosis is considered the histological ‘gold standard’ for evaluation of skin photoaging, but the relation of the level of dermal elastosis to other histological indicators of photoaging is not clear. Objective: To investigate how various proposed histological measures of photoaging compare with the level of dermal elastosis. Methods: Prospective, community-based study in Southeast Queensland, Australia, among 89 participants aged 40–82 years. Quantitative histology was used to evaluate 8 biomarkers of photoaged skin, and associations between grades of dermal elastosis and each of the other 7 biomarkers were analysed using ordinal logistic regression models with proportional odds assumption, using histological grades of elastosis as the outcome. Results: Older age, male sex and high outdoor exposure levels were confirmed as predictors ofhigh levels of dermal elastosis. After adjustment for age and sex, the only significant positive association with increasing elastosis grades was the proportion of p53-positive cells. Epidermal thickness, interdigitation index proportion of surface covered with melanin (% Fontana-Masson staining) and glycosaminoglycan content were not associated with elastosis in either crude or adjusted models. Conclusions: Amonga range of suggested biomarkers of photoaged skin, only p53-positive cells appear to be strongly associated with the level of dermal elastosis.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Dermatology</subject><subject>Dermis - chemistry</subject><subject>Dermis - pathology</subject><subject>Elastic Tissue - pathology</subject><subject>Epidermis - chemistry</subject><subject>Epidermis - pathology</subject><subject>Female</subject><subject>Glycosaminoglycans</subject><subject>Histology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melanins</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Queensland</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Sex Factors</subject><subject>Skin</subject><subject>Skin Aging - pathology</subject><subject>Sunlight - adverse effects</subject><subject>Tumor Suppressor Protein p53</subject><subject>Ultraviolet radiation</subject><issn>1018-8665</issn><issn>1421-9832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0MFLwzAUBvAgipvTg3eRIoh4qCZ5bZMcZagTJgrquaRZWrO1zUzag_-9GasTPCWQH9_L-xA6JfiGkFTcYowBaELTPTQmCSWx4ED3wx0THvMsS0foyPtlYJQzcYhGlAjBUorHKJvaZi2d8baNbBnNjO9sbSujZB09a-l7p_3m4W1l2uj103ZWVqatjtFBKWuvT4Zzgj4e7t-ns3j-8vg0vZvHCjLaxZnWaUEYAGCVFKnEkABTQiQFE0wrUhZAAQsgpUiAACcCGC8XXBIpFoRlMEFX29y1s1-99l3eGK90XctW297nAjMMYXkI8uKfXNreteFzuaAhiokwZ4Kut0g5673TZb52ppHuOyc431SZ76oM9nwI7ItGL3byt7sALgcgfairdLJVxv-5lIblUh7c2datpKu024Fhzg8yRICF</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Hughes, M.C.</creator><creator>Bredoux, C.</creator><creator>Salas, F.</creator><creator>Lombard, D.</creator><creator>Strutton, G.M.</creator><creator>Fourtanier, A.</creator><creator>Green, A.C.</creator><general>Karger</general><general>S. 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Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Sex Factors</topic><topic>Skin</topic><topic>Skin Aging - pathology</topic><topic>Sunlight - adverse effects</topic><topic>Tumor Suppressor Protein p53</topic><topic>Ultraviolet radiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hughes, M.C.</creatorcontrib><creatorcontrib>Bredoux, C.</creatorcontrib><creatorcontrib>Salas, F.</creatorcontrib><creatorcontrib>Lombard, D.</creatorcontrib><creatorcontrib>Strutton, G.M.</creatorcontrib><creatorcontrib>Fourtanier, A.</creatorcontrib><creatorcontrib>Green, A.C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Dermatology (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hughes, M.C.</au><au>Bredoux, C.</au><au>Salas, F.</au><au>Lombard, D.</au><au>Strutton, G.M.</au><au>Fourtanier, A.</au><au>Green, A.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Histological Measures of Skin Photoaging</atitle><jtitle>Dermatology (Basel)</jtitle><addtitle>Dermatology</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>223</volume><issue>2</issue><spage>140</spage><epage>151</epage><pages>140-151</pages><issn>1018-8665</issn><eissn>1421-9832</eissn><abstract>Background: Dermal elastosis is considered the histological ‘gold standard’ for evaluation of skin photoaging, but the relation of the level of dermal elastosis to other histological indicators of photoaging is not clear. Objective: To investigate how various proposed histological measures of photoaging compare with the level of dermal elastosis. Methods: Prospective, community-based study in Southeast Queensland, Australia, among 89 participants aged 40–82 years. Quantitative histology was used to evaluate 8 biomarkers of photoaged skin, and associations between grades of dermal elastosis and each of the other 7 biomarkers were analysed using ordinal logistic regression models with proportional odds assumption, using histological grades of elastosis as the outcome. Results: Older age, male sex and high outdoor exposure levels were confirmed as predictors ofhigh levels of dermal elastosis. After adjustment for age and sex, the only significant positive association with increasing elastosis grades was the proportion of p53-positive cells. Epidermal thickness, interdigitation index proportion of surface covered with melanin (% Fontana-Masson staining) and glycosaminoglycan content were not associated with elastosis in either crude or adjusted models. Conclusions: Amonga range of suggested biomarkers of photoaged skin, only p53-positive cells appear to be strongly associated with the level of dermal elastosis.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>21997520</pmid><doi>10.1159/000332425</doi><tpages>12</tpages></addata></record> |
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| subjects | Adult Age Factors Aged Aged, 80 and over Aging Biological and medical sciences Biomarkers Dermatology Dermis - chemistry Dermis - pathology Elastic Tissue - pathology Epidermis - chemistry Epidermis - pathology Female Glycosaminoglycans Histology Humans Immunohistochemistry Logistic Models Male Medical sciences Melanins Middle Aged Original Paper Queensland Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Sex Factors Skin Skin Aging - pathology Sunlight - adverse effects Tumor Suppressor Protein p53 Ultraviolet radiation |
| title | Comparison of Histological Measures of Skin Photoaging |
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