GPG-NH2 acts via the metabolite [alpha]HGA to target HIV-1 Env to the ER-associated protein degradation pathway

Abstract Background: The synthetic peptide glycyl-prolyl-glycine amide (GPG-NH2 ) was previously shown to abolish the ability of HIV-1 particles to fuse with the target cells, by reducing the content of the viral envelope glycoprotein (Env) in progeny HIV-1 particles. The loss of Env was found to re...

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Veröffentlicht in:	Retrovirology 2010-01, Vol.7, p.20
Hauptverfasser:	Jejcic, Alenka, Höglund, Stefan, Vahlne, Anders
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Cytoplasm Membranes Metabolites
Online-Zugang:	Volltext
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