Sonoporation-mediated anti-angiogenic gene transfer into muscle effectively regresses distant orthotopic tumors

Ultrasound (US) is an effective tool for local delivery of genes into target tumors or organs. In combination with microbubbles, US can temporarily change the permeability of cell membranes by cavitation and facilitate entry of plasmid DNA into cells. Here, we demonstrate that repeated US-mediated d...

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Veröffentlicht in:	Cancer gene therapy 2012-03, Vol.19 (3), p.171-180
Hauptverfasser:	Liao, Z-K, Tsai, K-C, Wang, H-T, Tseng, S-H, Deng, W-P, Chen, W-S, Hwang, L-H
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Angiogenesis Animals Antibiotics, Antineoplastic - pharmacology Antitumor activity Apoptosis Biomedical and Life Sciences Biomedicine Brain tumors Calreticulin Calreticulin - biosynthesis Calreticulin - genetics Care and treatment Cavitation Cell Line, Tumor Cell membranes Chemotherapy Combined Modality Therapy Cytokines Doxorubicin Doxorubicin - pharmacology Endostatin Endostatins - biosynthesis Endostatins - genetics Gene Expression Gene Therapy Gene Transfer Techniques Genetic aspects Genetic Therapy Health aspects Humans Immunotherapy Lymphocytes Male Membrane permeability Mice Mice, Inbred BALB C Mice, Inbred C57BL Molecular Sequence Data Neoplasms - blood supply Neoplasms - genetics Neoplasms - therapy Neovascularization, Pathologic - genetics Neovascularization, Pathologic - therapy original-article Random Allocation Rats Rats, Inbred F344 Sonication - methods Tumor-infiltrating lymphocytes Tumors Ultrasonic waves Ultrasonics - methods
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