p53 mutations and codon 213 polymorphism of p53 in lung cancers of former uranium miners

There is a high prevalence of G-->T transversions of p53 in lung cancers of smokers. One study has reported a special "hotspot" mutation at codon 249 of p53 in lung cancers of former uranium miners. The aim of our study was to look for mutational spectra of p53 in former German uranium...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 1999, Vol.125 (5), p.309-312
Hauptverfasser:	POPP, W, VAHRENHOLZ, C, SCHUSTER, H, WIESNER, B, BAUER, P, TÄUSCHER, F, PLOGMANN, H, MORGENROTH, K, KONIETZKO, N, NORPOTH, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Codon - genetics DNA Primers Exons Genes, p53 - genetics Humans Lung Neoplasms - etiology Lung Neoplasms - genetics Male Medical sciences Mining Mutation Occupational Diseases - etiology Occupational Diseases - genetics Pneumology Polymorphism, Genetic Tumors of the respiratory system and mediastinum Uranium - adverse effects
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