p53 mutations and codon 213 polymorphism of p53 in lung cancers of former uranium miners
There is a high prevalence of G-->T transversions of p53 in lung cancers of smokers. One study has reported a special "hotspot" mutation at codon 249 of p53 in lung cancers of former uranium miners. The aim of our study was to look for mutational spectra of p53 in former German uranium...
Gespeichert in:
| Veröffentlicht in: | Journal of cancer research and clinical oncology 1999, Vol.125 (5), p.309-312 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 312 |
|---|---|
| container_issue | 5 |
| container_start_page | 309 |
| container_title | Journal of cancer research and clinical oncology |
| container_volume | 125 |
| creator | POPP, W VAHRENHOLZ, C SCHUSTER, H WIESNER, B BAUER, P TÄUSCHER, F PLOGMANN, H MORGENROTH, K KONIETZKO, N NORPOTH, K |
| description | There is a high prevalence of G-->T transversions of p53 in lung cancers of smokers. One study has reported a special "hotspot" mutation at codon 249 of p53 in lung cancers of former uranium miners. The aim of our study was to look for mutational spectra of p53 in former German uranium miners with lung cancers.
We investigated 16 patients with lung cancer who had worked as uranium miners in Germany and 13 lung cancer patients without a mining history of the same region. By means of the polymerase chain reaction and sequencing we looked for mutations in exons 5 7 of the p53 gene.
We could not find any suggestion of hotspot mutations. The only G-->T mutation in former uranium miners was detected in the only nonsmoker. In 3 patients (19% of the total) we found a codon 213/3 polymorphism.
The results indicate that G-->T transversions do not seem to be very common mutations in p53 in lung cancers probably caused by radiation. Therefore, p53 may be mutated early in lung cancer development if radiation exposure is a critical factor in carcinogenesis. In accordance with studies of thyroid cancer patients in the Chernobyl region, our results may indicate an overrepresentation of codon 213/3 polymorphism in p53 in radiation-caused cancers. |
| doi_str_mv | 10.1007/s004320050279 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_921443725</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2586308721</sourcerecordid><originalsourceid>FETCH-LOGICAL-c345t-5be87a59c409d096bbc06f6675761380c65dd8f7017713f9437abccabada1b9b3</originalsourceid><addsrcrecordid>eNpV0M9LwzAUB_AgipvTo1cJ4rX6XtM0zVGGv2DgRcFbSdNGO5akJu1h_70ZG6in8JIPL-99CblEuEUAcRcBCpYDcMiFPCJzTFWGjPFjMgcUmPEcyxk5i3ENqeYiPyUzBMYlMjEnHwNn1E6jGnvvIlWupdq33tEcGR38Zmt9GL76aKk3dGd7RzeT-6RaOd2FuLs2Ptgu0Cko10-W2t6lh3NyYtQmdheHc0HeHx_els_Z6vXpZXm_yjQr-JjxpquE4lIXIFuQZdNoKE1ZpkFLZBXokrdtZUQaXSAzsmBCNVqrRrUKG9mwBbne9x2C_566ONZrPwWXvqxljkXyOU8o2yMdfIyhM_UQeqvCtkaodzHW_2JM_urQdGps1_7R-9wSuDkAFbXamLS67uOvE0JWFbIfT8B4Gg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>921443725</pqid></control><display><type>article</type><title>p53 mutations and codon 213 polymorphism of p53 in lung cancers of former uranium miners</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>POPP, W ; VAHRENHOLZ, C ; SCHUSTER, H ; WIESNER, B ; BAUER, P ; TÄUSCHER, F ; PLOGMANN, H ; MORGENROTH, K ; KONIETZKO, N ; NORPOTH, K</creator><creatorcontrib>POPP, W ; VAHRENHOLZ, C ; SCHUSTER, H ; WIESNER, B ; BAUER, P ; TÄUSCHER, F ; PLOGMANN, H ; MORGENROTH, K ; KONIETZKO, N ; NORPOTH, K</creatorcontrib><description>There is a high prevalence of G-->T transversions of p53 in lung cancers of smokers. One study has reported a special "hotspot" mutation at codon 249 of p53 in lung cancers of former uranium miners. The aim of our study was to look for mutational spectra of p53 in former German uranium miners with lung cancers.
We investigated 16 patients with lung cancer who had worked as uranium miners in Germany and 13 lung cancer patients without a mining history of the same region. By means of the polymerase chain reaction and sequencing we looked for mutations in exons 5 7 of the p53 gene.
We could not find any suggestion of hotspot mutations. The only G-->T mutation in former uranium miners was detected in the only nonsmoker. In 3 patients (19% of the total) we found a codon 213/3 polymorphism.
The results indicate that G-->T transversions do not seem to be very common mutations in p53 in lung cancers probably caused by radiation. Therefore, p53 may be mutated early in lung cancer development if radiation exposure is a critical factor in carcinogenesis. In accordance with studies of thyroid cancer patients in the Chernobyl region, our results may indicate an overrepresentation of codon 213/3 polymorphism in p53 in radiation-caused cancers.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s004320050279</identifier><identifier>PMID: 10359137</identifier><identifier>CODEN: JCROD7</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Biological and medical sciences ; Codon - genetics ; DNA Primers ; Exons ; Genes, p53 - genetics ; Humans ; Lung Neoplasms - etiology ; Lung Neoplasms - genetics ; Male ; Medical sciences ; Mining ; Mutation ; Occupational Diseases - etiology ; Occupational Diseases - genetics ; Pneumology ; Polymorphism, Genetic ; Tumors of the respiratory system and mediastinum ; Uranium - adverse effects</subject><ispartof>Journal of cancer research and clinical oncology, 1999, Vol.125 (5), p.309-312</ispartof><rights>1999 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-5be87a59c409d096bbc06f6675761380c65dd8f7017713f9437abccabada1b9b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1779881$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10359137$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>POPP, W</creatorcontrib><creatorcontrib>VAHRENHOLZ, C</creatorcontrib><creatorcontrib>SCHUSTER, H</creatorcontrib><creatorcontrib>WIESNER, B</creatorcontrib><creatorcontrib>BAUER, P</creatorcontrib><creatorcontrib>TÄUSCHER, F</creatorcontrib><creatorcontrib>PLOGMANN, H</creatorcontrib><creatorcontrib>MORGENROTH, K</creatorcontrib><creatorcontrib>KONIETZKO, N</creatorcontrib><creatorcontrib>NORPOTH, K</creatorcontrib><title>p53 mutations and codon 213 polymorphism of p53 in lung cancers of former uranium miners</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><description>There is a high prevalence of G-->T transversions of p53 in lung cancers of smokers. One study has reported a special "hotspot" mutation at codon 249 of p53 in lung cancers of former uranium miners. The aim of our study was to look for mutational spectra of p53 in former German uranium miners with lung cancers.
We investigated 16 patients with lung cancer who had worked as uranium miners in Germany and 13 lung cancer patients without a mining history of the same region. By means of the polymerase chain reaction and sequencing we looked for mutations in exons 5 7 of the p53 gene.
We could not find any suggestion of hotspot mutations. The only G-->T mutation in former uranium miners was detected in the only nonsmoker. In 3 patients (19% of the total) we found a codon 213/3 polymorphism.
The results indicate that G-->T transversions do not seem to be very common mutations in p53 in lung cancers probably caused by radiation. Therefore, p53 may be mutated early in lung cancer development if radiation exposure is a critical factor in carcinogenesis. In accordance with studies of thyroid cancer patients in the Chernobyl region, our results may indicate an overrepresentation of codon 213/3 polymorphism in p53 in radiation-caused cancers.</description><subject>Biological and medical sciences</subject><subject>Codon - genetics</subject><subject>DNA Primers</subject><subject>Exons</subject><subject>Genes, p53 - genetics</subject><subject>Humans</subject><subject>Lung Neoplasms - etiology</subject><subject>Lung Neoplasms - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mining</subject><subject>Mutation</subject><subject>Occupational Diseases - etiology</subject><subject>Occupational Diseases - genetics</subject><subject>Pneumology</subject><subject>Polymorphism, Genetic</subject><subject>Tumors of the respiratory system and mediastinum</subject><subject>Uranium - adverse effects</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpV0M9LwzAUB_AgipvTo1cJ4rX6XtM0zVGGv2DgRcFbSdNGO5akJu1h_70ZG6in8JIPL-99CblEuEUAcRcBCpYDcMiFPCJzTFWGjPFjMgcUmPEcyxk5i3ENqeYiPyUzBMYlMjEnHwNn1E6jGnvvIlWupdq33tEcGR38Zmt9GL76aKk3dGd7RzeT-6RaOd2FuLs2Ptgu0Cko10-W2t6lh3NyYtQmdheHc0HeHx_els_Z6vXpZXm_yjQr-JjxpquE4lIXIFuQZdNoKE1ZpkFLZBXokrdtZUQaXSAzsmBCNVqrRrUKG9mwBbne9x2C_566ONZrPwWXvqxljkXyOU8o2yMdfIyhM_UQeqvCtkaodzHW_2JM_urQdGps1_7R-9wSuDkAFbXamLS67uOvE0JWFbIfT8B4Gg</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>POPP, W</creator><creator>VAHRENHOLZ, C</creator><creator>SCHUSTER, H</creator><creator>WIESNER, B</creator><creator>BAUER, P</creator><creator>TÄUSCHER, F</creator><creator>PLOGMANN, H</creator><creator>MORGENROTH, K</creator><creator>KONIETZKO, N</creator><creator>NORPOTH, K</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>1999</creationdate><title>p53 mutations and codon 213 polymorphism of p53 in lung cancers of former uranium miners</title><author>POPP, W ; VAHRENHOLZ, C ; SCHUSTER, H ; WIESNER, B ; BAUER, P ; TÄUSCHER, F ; PLOGMANN, H ; MORGENROTH, K ; KONIETZKO, N ; NORPOTH, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-5be87a59c409d096bbc06f6675761380c65dd8f7017713f9437abccabada1b9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Biological and medical sciences</topic><topic>Codon - genetics</topic><topic>DNA Primers</topic><topic>Exons</topic><topic>Genes, p53 - genetics</topic><topic>Humans</topic><topic>Lung Neoplasms - etiology</topic><topic>Lung Neoplasms - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mining</topic><topic>Mutation</topic><topic>Occupational Diseases - etiology</topic><topic>Occupational Diseases - genetics</topic><topic>Pneumology</topic><topic>Polymorphism, Genetic</topic><topic>Tumors of the respiratory system and mediastinum</topic><topic>Uranium - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>POPP, W</creatorcontrib><creatorcontrib>VAHRENHOLZ, C</creatorcontrib><creatorcontrib>SCHUSTER, H</creatorcontrib><creatorcontrib>WIESNER, B</creatorcontrib><creatorcontrib>BAUER, P</creatorcontrib><creatorcontrib>TÄUSCHER, F</creatorcontrib><creatorcontrib>PLOGMANN, H</creatorcontrib><creatorcontrib>MORGENROTH, K</creatorcontrib><creatorcontrib>KONIETZKO, N</creatorcontrib><creatorcontrib>NORPOTH, K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>POPP, W</au><au>VAHRENHOLZ, C</au><au>SCHUSTER, H</au><au>WIESNER, B</au><au>BAUER, P</au><au>TÄUSCHER, F</au><au>PLOGMANN, H</au><au>MORGENROTH, K</au><au>KONIETZKO, N</au><au>NORPOTH, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>p53 mutations and codon 213 polymorphism of p53 in lung cancers of former uranium miners</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>1999</date><risdate>1999</risdate><volume>125</volume><issue>5</issue><spage>309</spage><epage>312</epage><pages>309-312</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><coden>JCROD7</coden><abstract>There is a high prevalence of G-->T transversions of p53 in lung cancers of smokers. One study has reported a special "hotspot" mutation at codon 249 of p53 in lung cancers of former uranium miners. The aim of our study was to look for mutational spectra of p53 in former German uranium miners with lung cancers.
We investigated 16 patients with lung cancer who had worked as uranium miners in Germany and 13 lung cancer patients without a mining history of the same region. By means of the polymerase chain reaction and sequencing we looked for mutations in exons 5 7 of the p53 gene.
We could not find any suggestion of hotspot mutations. The only G-->T mutation in former uranium miners was detected in the only nonsmoker. In 3 patients (19% of the total) we found a codon 213/3 polymorphism.
The results indicate that G-->T transversions do not seem to be very common mutations in p53 in lung cancers probably caused by radiation. Therefore, p53 may be mutated early in lung cancer development if radiation exposure is a critical factor in carcinogenesis. In accordance with studies of thyroid cancer patients in the Chernobyl region, our results may indicate an overrepresentation of codon 213/3 polymorphism in p53 in radiation-caused cancers.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>10359137</pmid><doi>10.1007/s004320050279</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0171-5216 |
| ispartof | Journal of cancer research and clinical oncology, 1999, Vol.125 (5), p.309-312 |
| issn | 0171-5216 1432-1335 |
| language | eng |
| recordid | cdi_proquest_journals_921443725 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Biological and medical sciences Codon - genetics DNA Primers Exons Genes, p53 - genetics Humans Lung Neoplasms - etiology Lung Neoplasms - genetics Male Medical sciences Mining Mutation Occupational Diseases - etiology Occupational Diseases - genetics Pneumology Polymorphism, Genetic Tumors of the respiratory system and mediastinum Uranium - adverse effects |
| title | p53 mutations and codon 213 polymorphism of p53 in lung cancers of former uranium miners |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T03%3A17%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=p53%20mutations%20and%20codon%20213%20polymorphism%20of%20p53%20in%20lung%20cancers%20of%20former%20uranium%20miners&rft.jtitle=Journal%20of%20cancer%20research%20and%20clinical%20oncology&rft.au=POPP,%20W&rft.date=1999&rft.volume=125&rft.issue=5&rft.spage=309&rft.epage=312&rft.pages=309-312&rft.issn=0171-5216&rft.eissn=1432-1335&rft.coden=JCROD7&rft_id=info:doi/10.1007/s004320050279&rft_dat=%3Cproquest_cross%3E2586308721%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=921443725&rft_id=info:pmid/10359137&rfr_iscdi=true |