Mechanisms of resistance to methotrexate in childhood acute lymphoblastic leukemia : circumvention of thymidylate synthase inhibition

In about 25% of patients suffering from acute lymphoblastic leukemia (ALL) treatment failures occur that are most likely due to development of resistance to methotrexate (MTX). Blasts from patients with ALL were evaluated for MTX uptake, formation of long-chain MTX polyglutamates (MTX-Glu5+6), cytot...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of cancer research and clinical oncology 1999-08, Vol.125 (8-9), p.513-519
Hauptverfasser:	WEIGAND, M, FREI, E, GRAF, N, BUCHHOLZ, B, WOLFROM, C, BREUER, A, WIESSLER, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antimetabolites, Antineoplastic - pharmacology Antimetabolites, Antineoplastic - therapeutic use Antineoplastic agents Biological and medical sciences Child Child, Preschool Female General aspects Humans Infant Leukemia, Myeloid, Acute - enzymology Male Medical sciences Methotrexate - pharmacology Methotrexate - therapeutic use Pharmacology. Drug treatments Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology Recurrence Thymidylate Synthase - antagonists & inhibitors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!