Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells

Background Glioblastoma remains one of the most devastating human malignancies, and despite therapeutic advances, there are no drugs that significantly improve the patient survival. Altered expression of the Aurora kinases was found in different malignancies, and their inhibition has been studied in...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2012-03, Vol.138 (3), p.405-414
Hauptverfasser:	Borges, Kleiton Silva, Castro-Gamero, Angel Maurício, Moreno, Daniel Antunes, da Silva Silveira, Vanessa, Brassesco, Maria Sol, de Paula Queiroz, Rosane Gomes, de Oliveira, Harley Francisco, Carlotti, Carlos Gilberto, Scrideli, Carlos Alberto, Tone, Luiz Gonzaga
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents, Alkylating - pharmacology Apoptosis - drug effects Aurora Kinase B Aurora Kinases Benzamides - pharmacology Biological and medical sciences Blotting, Western Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - enzymology Cancer Research Cell Line, Tumor Cell Proliferation Cellular biology Dacarbazine - analogs & derivatives Dacarbazine - pharmacology Gene expression Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Glioblastoma - drug therapy Glioblastoma - enzymology Hematology Humans Internal Medicine Kinases Medical sciences Medicine Medicine & Public Health Neurology Oncology Original Paper Pharmacology Pharmacology. Drug treatments Protein Kinase Inhibitors - pharmacology Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Quinazolines - pharmacology Radiation-Sensitizing Agents - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA, Neoplasm - isolation & purification Time Factors Tumors of the nervous system. Phacomatoses
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