UV Light B–Mediated Inhibition of Skin Catalase Activity Promotes Gr-1+CD11b+ Myeloid Cell Expansion

Skin cancer incidence and mortality are higher in men compared with women, but the causes of this sex discrepancy remain largely unknown. UV light exposure induces cutaneous inflammation and neutralizes cutaneous antioxidants. Gr-1+CD11b+ myeloid cells are heterogeneous bone marrow–derived cells tha...

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Veröffentlicht in:	Journal of investigative dermatology 2012-03, Vol.132 (3), p.695-702
Hauptverfasser:	Sullivan, Nicholas J., Tober, Kathleen L., Burns, Erin M., Schick, Jonathan S., Riggenbach, Judith A., Mace, Thomas A., Bill, Matthew A., Young, Gregory S., Oberyszyn, Tatiana M., Lesinski, Gregory B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Catalase - radiation effects CD11b Antigen - metabolism Cell Proliferation Dermatology Female Inflammation - etiology Inflammation - metabolism Male Medical sciences Mice Mice, Hairless Myeloid Cells - enzymology Myeloid Cells - pathology Myeloid Cells - radiation effects Neoplasms, Radiation-Induced - pathology Receptors, Chemokine - metabolism Sex Factors Skin - enzymology Skin - pathology Skin - radiation effects Skin Neoplasms - pathology Ultraviolet Rays
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