Melatonin attenuates clock gene Cryptochrome1, which may aggravates mouse anti-type II collagen antibody-induced arthritis

Melatonin attenuates clock gene Cryptochrome1, which may aggravates mouse anti-type II collagen antibody-induced arthritis

Very recently, the circadian rhythm was proved to play an important role in the pathogenesis of arthritis. The role of melatonin in the development and progress of rheumatoid arthritis has been implicated for decades. This study was aimed to investigate the effect of melatonin on the expression of c...

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Veröffentlicht in:Rheumatology international 2012-02, Vol.32 (2), p.379-385
Hauptverfasser: Bang, Jihye, Chang, Hyuk Won, Jung, Hae-Ra, Cho, Chul-Hyun, Hur, Ji-An, Lee, Sang-Il, Choi, Tae Hyun, Kim, Sang-Hyon, Ha, Eunyoung
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container_end_page 385
container_issue 2
container_start_page 379
container_title Rheumatology international
container_volume 32
creator Bang, Jihye
Chang, Hyuk Won
Jung, Hae-Ra
Cho, Chul-Hyun
Hur, Ji-An
Lee, Sang-Il
Choi, Tae Hyun
Kim, Sang-Hyon
Ha, Eunyoung
description Very recently, the circadian rhythm was proved to play an important role in the pathogenesis of arthritis. The role of melatonin in the development and progress of rheumatoid arthritis has been implicated for decades. This study was aimed to investigate the effect of melatonin on the expression of circadian clock genes in mouse anti-type II collagen antibody-induced arthritis (CIA). Mice were divided into 3 groups: control, CIA, and CIA + melatonin treatment (MLT). Both mRNA and protein levels of circadian clock gene Cryptochrome1 ( Cry1 ) were markedly decreased in CIA + MEL group compared with those in control and CIA groups. MLT increased paw thickness. Histologic and X-ray assessment also revealed increased infiltration of inflammatory cells, synovial hyperplasia, and the destruction of articular cartilage and bone by MLT. The concentrations of anti-type II collagen antibody in CIA + MEL group mice were significantly higher than those in control and CIA groups ( P  
doi_str_mv 10.1007/s00296-010-1641-9
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The role of melatonin in the development and progress of rheumatoid arthritis has been implicated for decades. This study was aimed to investigate the effect of melatonin on the expression of circadian clock genes in mouse anti-type II collagen antibody-induced arthritis (CIA). Mice were divided into 3 groups: control, CIA, and CIA + melatonin treatment (MLT). Both mRNA and protein levels of circadian clock gene Cryptochrome1 ( Cry1 ) were markedly decreased in CIA + MEL group compared with those in control and CIA groups. MLT increased paw thickness. Histologic and X-ray assessment also revealed increased infiltration of inflammatory cells, synovial hyperplasia, and the destruction of articular cartilage and bone by MLT. The concentrations of anti-type II collagen antibody in CIA + MEL group mice were significantly higher than those in control and CIA groups ( P  &lt; 0.05). Serum concentrations of TNF-α ( P  &lt; 0.005) and IL-6 ( P  &lt; 0.05) in CIA + MLT group were also increased. Taken together, these results implicate that clock gene Cry1 may be involved in the aggravation of MLT-mediated arthritis in mice anti-type II collagen antibody-induced arthritis.</description><identifier>ISSN: 0172-8172</identifier><identifier>EISSN: 1437-160X</identifier><identifier>DOI: 10.1007/s00296-010-1641-9</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Medicine ; Medicine &amp; Public Health ; Original Article ; Rheumatology</subject><ispartof>Rheumatology international, 2012-02, Vol.32 (2), p.379-385</ispartof><rights>Springer-Verlag 2010</rights><rights>Springer-Verlag 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-d6e2c530ff9df9580461acb9735b44f2330e02995c76ce330db5d674c214aad3</citedby><cites>FETCH-LOGICAL-c381t-d6e2c530ff9df9580461acb9735b44f2330e02995c76ce330db5d674c214aad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00296-010-1641-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00296-010-1641-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Bang, Jihye</creatorcontrib><creatorcontrib>Chang, Hyuk Won</creatorcontrib><creatorcontrib>Jung, Hae-Ra</creatorcontrib><creatorcontrib>Cho, Chul-Hyun</creatorcontrib><creatorcontrib>Hur, Ji-An</creatorcontrib><creatorcontrib>Lee, Sang-Il</creatorcontrib><creatorcontrib>Choi, Tae Hyun</creatorcontrib><creatorcontrib>Kim, Sang-Hyon</creatorcontrib><creatorcontrib>Ha, Eunyoung</creatorcontrib><title>Melatonin attenuates clock gene Cryptochrome1, which may aggravates mouse anti-type II collagen antibody-induced arthritis</title><title>Rheumatology international</title><addtitle>Rheumatol Int</addtitle><description>Very recently, the circadian rhythm was proved to play an important role in the pathogenesis of arthritis. 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Medicine & Public Health
Original Article
Rheumatology
title Melatonin attenuates clock gene Cryptochrome1, which may aggravates mouse anti-type II collagen antibody-induced arthritis
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