Subversion of innate immune responses by bacterial hindrance of NF-[kappa]B pathway

Summary Bacterial infections cause substantial mortality and burden of disease globally. Induction of a strong innate inflammatory response is the first common host mechanism required for elimination of the invading pathogens. The host transcription factor, nuclear factor kappa B (NF-κB) is essentia...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cellular microbiology 2012-02, Vol.14 (2), p.155
1. Verfasser: Le Negrate, Gaëlle
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 2
container_start_page 155
container_title Cellular microbiology
container_volume 14
creator Le Negrate, Gaëlle
description Summary Bacterial infections cause substantial mortality and burden of disease globally. Induction of a strong innate inflammatory response is the first common host mechanism required for elimination of the invading pathogens. The host transcription factor, nuclear factor kappa B (NF-κB) is essential for immune activation. Conversely, bacterial pathogens have evolved strategies to interfere directly with host cell signalling by regulating or mimicking host proteins. Given the key role of NF-κB in the host inflammatory response, bacteria have expectedly developed virulence effectors interfering with NF-κB signalling pathways. In this review, we explore the bacterial mechanisms utilized to prevent effective NF-κB signalling, which in turn usurp the host inflammatory response.
format Article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_916733749</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2564479841</sourcerecordid><originalsourceid>FETCH-proquest_journals_9167337493</originalsourceid><addsrcrecordid>eNqNjk0LgkAURYcoyD7-w9BecNQ0t0XSqk3tIuRpTxzTmWlmLPz3GUTrVvfCuQfuiDgsjHx3vfH98a-zcEpmxtSex6KYMYecTl3-RG24FFSWlAsBFilv204g1WiUFAYNzXuaQ2FRc2hoxcVNgyjwYxxT93IHpeC6pQps9YJ-QSYlNAaX35yTVbo_7w6u0vLRobFZLTstBpQlw40giMMk-Gv0Btq8QQ8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>916733749</pqid></control><display><type>article</type><title>Subversion of innate immune responses by bacterial hindrance of NF-[kappa]B pathway</title><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Free Content</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Le Negrate, Gaëlle</creator><creatorcontrib>Le Negrate, Gaëlle</creatorcontrib><description>Summary Bacterial infections cause substantial mortality and burden of disease globally. Induction of a strong innate inflammatory response is the first common host mechanism required for elimination of the invading pathogens. The host transcription factor, nuclear factor kappa B (NF-κB) is essential for immune activation. Conversely, bacterial pathogens have evolved strategies to interfere directly with host cell signalling by regulating or mimicking host proteins. Given the key role of NF-κB in the host inflammatory response, bacteria have expectedly developed virulence effectors interfering with NF-κB signalling pathways. In this review, we explore the bacterial mechanisms utilized to prevent effective NF-κB signalling, which in turn usurp the host inflammatory response.</description><identifier>ISSN: 1462-5814</identifier><identifier>EISSN: 1462-5822</identifier><language>eng</language><publisher>Oxford: Hindawi Limited</publisher><ispartof>Cellular microbiology, 2012-02, Vol.14 (2), p.155</ispartof><rights>2011 Blackwell Publishing Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>Le Negrate, Gaëlle</creatorcontrib><title>Subversion of innate immune responses by bacterial hindrance of NF-[kappa]B pathway</title><title>Cellular microbiology</title><description>Summary Bacterial infections cause substantial mortality and burden of disease globally. Induction of a strong innate inflammatory response is the first common host mechanism required for elimination of the invading pathogens. The host transcription factor, nuclear factor kappa B (NF-κB) is essential for immune activation. Conversely, bacterial pathogens have evolved strategies to interfere directly with host cell signalling by regulating or mimicking host proteins. Given the key role of NF-κB in the host inflammatory response, bacteria have expectedly developed virulence effectors interfering with NF-κB signalling pathways. In this review, we explore the bacterial mechanisms utilized to prevent effective NF-κB signalling, which in turn usurp the host inflammatory response.</description><issn>1462-5814</issn><issn>1462-5822</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqNjk0LgkAURYcoyD7-w9BecNQ0t0XSqk3tIuRpTxzTmWlmLPz3GUTrVvfCuQfuiDgsjHx3vfH98a-zcEpmxtSex6KYMYecTl3-RG24FFSWlAsBFilv204g1WiUFAYNzXuaQ2FRc2hoxcVNgyjwYxxT93IHpeC6pQps9YJ-QSYlNAaX35yTVbo_7w6u0vLRobFZLTstBpQlw40giMMk-Gv0Btq8QQ8</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Le Negrate, Gaëlle</creator><general>Hindawi Limited</general><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>20120201</creationdate><title>Subversion of innate immune responses by bacterial hindrance of NF-[kappa]B pathway</title><author>Le Negrate, Gaëlle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_9167337493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Le Negrate, Gaëlle</creatorcontrib><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Cellular microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Le Negrate, Gaëlle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subversion of innate immune responses by bacterial hindrance of NF-[kappa]B pathway</atitle><jtitle>Cellular microbiology</jtitle><date>2012-02-01</date><risdate>2012</risdate><volume>14</volume><issue>2</issue><spage>155</spage><pages>155-</pages><issn>1462-5814</issn><eissn>1462-5822</eissn><abstract>Summary Bacterial infections cause substantial mortality and burden of disease globally. Induction of a strong innate inflammatory response is the first common host mechanism required for elimination of the invading pathogens. The host transcription factor, nuclear factor kappa B (NF-κB) is essential for immune activation. Conversely, bacterial pathogens have evolved strategies to interfere directly with host cell signalling by regulating or mimicking host proteins. Given the key role of NF-κB in the host inflammatory response, bacteria have expectedly developed virulence effectors interfering with NF-κB signalling pathways. In this review, we explore the bacterial mechanisms utilized to prevent effective NF-κB signalling, which in turn usurp the host inflammatory response.</abstract><cop>Oxford</cop><pub>Hindawi Limited</pub></addata></record>
fulltext fulltext
identifier ISSN: 1462-5814
ispartof Cellular microbiology, 2012-02, Vol.14 (2), p.155
issn 1462-5814
1462-5822
language eng
recordid cdi_proquest_journals_916733749
source Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection
title Subversion of innate immune responses by bacterial hindrance of NF-[kappa]B pathway
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T07%3A34%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Subversion%20of%20innate%20immune%20responses%20by%20bacterial%20hindrance%20of%20NF-%5Bkappa%5DB%20pathway&rft.jtitle=Cellular%20microbiology&rft.au=Le%20Negrate,%20Ga%C3%ABlle&rft.date=2012-02-01&rft.volume=14&rft.issue=2&rft.spage=155&rft.pages=155-&rft.issn=1462-5814&rft.eissn=1462-5822&rft_id=info:doi/&rft_dat=%3Cproquest%3E2564479841%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=916733749&rft_id=info:pmid/&rfr_iscdi=true