Absence of Integrin [alpha]v[Beta]3 Enhances Vascular Leak in Mice by Inhibiting Endothelial Cortical Actin Formation

Sepsis and acute lung injury (ALI) have devastatingly high mortality rates. Both are associated with increased vascular leak, a process regulated by complex molecular mechanisms. We hypothesized that integrin αv[beta]3 could be an important determinant of vascular leak and endothelial permeability i...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2012-01, Vol.185 (1), p.58
Hauptverfasser:	Su, George, Atakilit, Amha, Li, John T, Wu, Nanyan, Bhattacharya, Mallar, Zhu, Jieling, Shieh, Jennifer E, Li, Elizabeth, Chen, Robert, Sun, Stephen, Su, Cynthia P, Sheppard, Dean
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Blood platelets Bone marrow Edema Endothelium Ligands Localization Mortality Permeability Sepsis Vascular endothelial growth factor
Online-Zugang:	Volltext
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