ARK5 is associated with the invasive and metastatic potential of human breast cancer cells

Purpose To investigate the effects of Akt/ARK5 pathways on the metastatic potential of human breast cancer cells. Materials and methods The human ARK5 gene was transfected into MDA-MB-231 cells. Effects of ARK5 on MDA-MB-231 cells were investigated in vitro. The tumorigenicity and spontaneously meta...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2012-02, Vol.138 (2), p.247-254
Hauptverfasser:	Chang, Xin-Zhong, Yu, Jie, Liu, Hai-Yin, Dong, Rui-Hua, Cao, Xu-Chen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Research Cell Adhesion - genetics Cell Line, Tumor Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Female Gene Expression Regulation, Neoplastic Genes Hematology Humans Internal Medicine Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Lung Neoplasms - secondary Matrix Metalloproteinase 14 - genetics Matrix Metalloproteinase 14 - metabolism Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Medicine Medicine & Public Health Metastasis Mice Mice, Inbred BALB C Mice, Nude Neoplasm Invasiveness Neoplasm Metastasis Oncology Original Paper Protein Kinases - genetics Protein Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism RNA Interference Transfection - methods
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