Ecotoxicogenomics to Support Ecological Risk Assessment: A Case Study with Bisphenol A in Fish
Effects of bisphenol A (BPA) on ovarian transcript profiles as well as targeted end points with endocrine/reproductive relevance were examined in two fish species, fathead minnow (Pimephales promelas) and zebrafish (Danio rerio), exposed in parallel using matched experimental designs. Four days of w...
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| Veröffentlicht in: | Environmental science & technology 2012-01, Vol.46 (1), p.51-59 |
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| creator | Villeneuve, Daniel L Garcia-Reyero, Natàlia Escalon, B. Lynn Jensen, Kathleen M Cavallin, Jenna E Makynen, Elizabeth A Durhan, Elizabeth J Kahl, Michael D Thomas, Linnea M Perkins, Edward J Ankley, Gerald T |
| description | Effects of bisphenol A (BPA) on ovarian transcript profiles as well as targeted end points with endocrine/reproductive relevance were examined in two fish species, fathead minnow (Pimephales promelas) and zebrafish (Danio rerio), exposed in parallel using matched experimental designs. Four days of waterborne exposure to 10 μg BPA/L caused significant vitellogenin induction in both species. However, zebrafish were less sensitive to effects on hepatic gene expression and steroid production than fathead minnow and the magnitude of vitellogenin induction was more modest (i.e., 3-fold compared to 13 000-fold in fathead minnow). The concentration–response at the ovarian transcriptome level was nonmonotonic and violated assumptions that underlie proposed methods for estimating hazard thresholds from transcriptomic results. However, the nonmonotonic profile was consistent among species and there were nominal similarities in the functions associated with the differentially expressed genes, suggesting potential activation of common pathway perturbation motifs in both species. Overall, the results provide an effective case study for considering the potential application of ecotoxicogenomics to ecological risk assessments and provide novel comparative data regarding effects of BPA in fish. |
| doi_str_mv | 10.1021/es201150a |
| format | Article |
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Lynn ; Jensen, Kathleen M ; Cavallin, Jenna E ; Makynen, Elizabeth A ; Durhan, Elizabeth J ; Kahl, Michael D ; Thomas, Linnea M ; Perkins, Edward J ; Ankley, Gerald T</creator><creatorcontrib>Villeneuve, Daniel L ; Garcia-Reyero, Natàlia ; Escalon, B. Lynn ; Jensen, Kathleen M ; Cavallin, Jenna E ; Makynen, Elizabeth A ; Durhan, Elizabeth J ; Kahl, Michael D ; Thomas, Linnea M ; Perkins, Edward J ; Ankley, Gerald T</creatorcontrib><description>Effects of bisphenol A (BPA) on ovarian transcript profiles as well as targeted end points with endocrine/reproductive relevance were examined in two fish species, fathead minnow (Pimephales promelas) and zebrafish (Danio rerio), exposed in parallel using matched experimental designs. Four days of waterborne exposure to 10 μg BPA/L caused significant vitellogenin induction in both species. However, zebrafish were less sensitive to effects on hepatic gene expression and steroid production than fathead minnow and the magnitude of vitellogenin induction was more modest (i.e., 3-fold compared to 13 000-fold in fathead minnow). The concentration–response at the ovarian transcriptome level was nonmonotonic and violated assumptions that underlie proposed methods for estimating hazard thresholds from transcriptomic results. However, the nonmonotonic profile was consistent among species and there were nominal similarities in the functions associated with the differentially expressed genes, suggesting potential activation of common pathway perturbation motifs in both species. Overall, the results provide an effective case study for considering the potential application of ecotoxicogenomics to ecological risk assessments and provide novel comparative data regarding effects of BPA in fish.</description><identifier>ISSN: 0013-936X</identifier><identifier>EISSN: 1520-5851</identifier><identifier>DOI: 10.1021/es201150a</identifier><identifier>PMID: 21786754</identifier><identifier>CODEN: ESTHAG</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Benzhydryl Compounds ; Bisphenol A ; Case studies ; Chemical compounds ; Cyprinidae - blood ; Cyprinidae - genetics ; Ecotoxicology - methods ; Female ; Fish ; Gene expression ; Gene Expression Regulation - drug effects ; Genomics ; Male ; Metagenomics - methods ; Oligonucleotide Array Sequence Analysis ; Ovaries ; Phenols - toxicity ; Principal Component Analysis ; Reproducibility of Results ; Risk Assessment ; Steroids ; Toxicity ; Toxicity Tests ; Transcriptome - drug effects ; Transcriptome - genetics ; Vitellogenins - blood ; Zebrafish - genetics</subject><ispartof>Environmental science & technology, 2012-01, Vol.46 (1), p.51-59</ispartof><rights>Copyright © 2011 American Chemical Society</rights><rights>Copyright American Chemical Society Jan 3, 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a341t-707194076100d19531a96262b077a966f0836661ea7786658d27ec3e72e70bfa3</citedby><cites>FETCH-LOGICAL-a341t-707194076100d19531a96262b077a966f0836661ea7786658d27ec3e72e70bfa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/es201150a$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/es201150a$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>315,782,786,2767,27083,27931,27932,56745,56795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21786754$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Villeneuve, Daniel L</creatorcontrib><creatorcontrib>Garcia-Reyero, Natàlia</creatorcontrib><creatorcontrib>Escalon, B. Lynn</creatorcontrib><creatorcontrib>Jensen, Kathleen M</creatorcontrib><creatorcontrib>Cavallin, Jenna E</creatorcontrib><creatorcontrib>Makynen, Elizabeth A</creatorcontrib><creatorcontrib>Durhan, Elizabeth J</creatorcontrib><creatorcontrib>Kahl, Michael D</creatorcontrib><creatorcontrib>Thomas, Linnea M</creatorcontrib><creatorcontrib>Perkins, Edward J</creatorcontrib><creatorcontrib>Ankley, Gerald T</creatorcontrib><title>Ecotoxicogenomics to Support Ecological Risk Assessment: A Case Study with Bisphenol A in Fish</title><title>Environmental science & technology</title><addtitle>Environ. Sci. Technol</addtitle><description>Effects of bisphenol A (BPA) on ovarian transcript profiles as well as targeted end points with endocrine/reproductive relevance were examined in two fish species, fathead minnow (Pimephales promelas) and zebrafish (Danio rerio), exposed in parallel using matched experimental designs. Four days of waterborne exposure to 10 μg BPA/L caused significant vitellogenin induction in both species. However, zebrafish were less sensitive to effects on hepatic gene expression and steroid production than fathead minnow and the magnitude of vitellogenin induction was more modest (i.e., 3-fold compared to 13 000-fold in fathead minnow). The concentration–response at the ovarian transcriptome level was nonmonotonic and violated assumptions that underlie proposed methods for estimating hazard thresholds from transcriptomic results. However, the nonmonotonic profile was consistent among species and there were nominal similarities in the functions associated with the differentially expressed genes, suggesting potential activation of common pathway perturbation motifs in both species. Overall, the results provide an effective case study for considering the potential application of ecotoxicogenomics to ecological risk assessments and provide novel comparative data regarding effects of BPA in fish.</description><subject>Animals</subject><subject>Benzhydryl Compounds</subject><subject>Bisphenol A</subject><subject>Case studies</subject><subject>Chemical compounds</subject><subject>Cyprinidae - blood</subject><subject>Cyprinidae - genetics</subject><subject>Ecotoxicology - methods</subject><subject>Female</subject><subject>Fish</subject><subject>Gene expression</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Genomics</subject><subject>Male</subject><subject>Metagenomics - methods</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Ovaries</subject><subject>Phenols - toxicity</subject><subject>Principal Component Analysis</subject><subject>Reproducibility of Results</subject><subject>Risk Assessment</subject><subject>Steroids</subject><subject>Toxicity</subject><subject>Toxicity Tests</subject><subject>Transcriptome - drug effects</subject><subject>Transcriptome - genetics</subject><subject>Vitellogenins - blood</subject><subject>Zebrafish - genetics</subject><issn>0013-936X</issn><issn>1520-5851</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkMFKw0AQhhdRbK0efAFZBA8eojObZDfxVkurQkGwCp4M23Tbbk27MZOgfXtXWuvB0wzMx_cPP2OnCFcIAq8NCUCMQe-xNsYCgjiJcZ-1ATAM0lC-ttgR0QIARAjJIWsJVIlUcdRmb_3c1e7L5m5mVm5pc-K146OmLF1Vc38s3MzmuuBPlt55l8gQLc2qvuFd3tNk-KhuJmv-aes5v7VUzr2l8De74gNL82N2MNUFmZPt7LCXQf-5dx8MH-8eet1hoMMI60CBwjQCJRFggmkcok6lkGIMSvlNTiEJpZRotPKPyziZCGXy0ChhFIynOuyw8423rNxHY6jOFq6pVj4ySzFSgBGkHrrcQHnliCozzcrKLnW1zhCynyKzXZGePdsKm_HSTHbkb3MeuNgAOqe_sP-ib1TUd04</recordid><startdate>20120103</startdate><enddate>20120103</enddate><creator>Villeneuve, Daniel L</creator><creator>Garcia-Reyero, Natàlia</creator><creator>Escalon, B. 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Lynn</au><au>Jensen, Kathleen M</au><au>Cavallin, Jenna E</au><au>Makynen, Elizabeth A</au><au>Durhan, Elizabeth J</au><au>Kahl, Michael D</au><au>Thomas, Linnea M</au><au>Perkins, Edward J</au><au>Ankley, Gerald T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ecotoxicogenomics to Support Ecological Risk Assessment: A Case Study with Bisphenol A in Fish</atitle><jtitle>Environmental science & technology</jtitle><addtitle>Environ. Sci. Technol</addtitle><date>2012-01-03</date><risdate>2012</risdate><volume>46</volume><issue>1</issue><spage>51</spage><epage>59</epage><pages>51-59</pages><issn>0013-936X</issn><eissn>1520-5851</eissn><coden>ESTHAG</coden><abstract>Effects of bisphenol A (BPA) on ovarian transcript profiles as well as targeted end points with endocrine/reproductive relevance were examined in two fish species, fathead minnow (Pimephales promelas) and zebrafish (Danio rerio), exposed in parallel using matched experimental designs. Four days of waterborne exposure to 10 μg BPA/L caused significant vitellogenin induction in both species. However, zebrafish were less sensitive to effects on hepatic gene expression and steroid production than fathead minnow and the magnitude of vitellogenin induction was more modest (i.e., 3-fold compared to 13 000-fold in fathead minnow). The concentration–response at the ovarian transcriptome level was nonmonotonic and violated assumptions that underlie proposed methods for estimating hazard thresholds from transcriptomic results. However, the nonmonotonic profile was consistent among species and there were nominal similarities in the functions associated with the differentially expressed genes, suggesting potential activation of common pathway perturbation motifs in both species. 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| subjects | Animals Benzhydryl Compounds Bisphenol A Case studies Chemical compounds Cyprinidae - blood Cyprinidae - genetics Ecotoxicology - methods Female Fish Gene expression Gene Expression Regulation - drug effects Genomics Male Metagenomics - methods Oligonucleotide Array Sequence Analysis Ovaries Phenols - toxicity Principal Component Analysis Reproducibility of Results Risk Assessment Steroids Toxicity Toxicity Tests Transcriptome - drug effects Transcriptome - genetics Vitellogenins - blood Zebrafish - genetics |
| title | Ecotoxicogenomics to Support Ecological Risk Assessment: A Case Study with Bisphenol A in Fish |
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