MTHFD1 G1958A, BHMT G742A, TC2 C776G and TC2 A67G polymorphisms and head and neck squamous cell carcinoma risk

Alterations in folate metabolism may contribute to the process of carcinogenesis by influencing DNA methylation and genomic stability. Polymorphisms in genes encoding enzymes involved in this pathway may alter enzyme activity and consequently interfere in concentrations of homocysteine and S-adenosy...

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Veröffentlicht in:	Molecular biology reports 2012-02, Vol.39 (2), p.887-893
Hauptverfasser:	da Silva, Lidia Maria Rebolho Batista, Galbiatti, Ana Lívia Silva, Ruiz, Mariangela Torreglosa, Raposo, Luiz Sérgio, Maniglia, José Victor, Pavarino, Érika Cristina, Goloni-Bertollo, Eny Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Anatomy Animal Biochemistry Betaine-Homocysteine S-Methyltransferase - genetics Biomedical and Life Sciences Brazil - epidemiology Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism DNA methylation DNA Methylation - genetics Female Folic Acid - metabolism Genomic Instability - genetics Head & neck cancer Head and Neck Neoplasms - epidemiology Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Histology Humans Life Sciences Logistic Models Male Methylenetetrahydrofolate Dehydrogenase (NADP) - genetics Minor Histocompatibility Antigens Molecular biology Morphology Polymerase Chain Reaction Polymorphism Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide - genetics Risk Factors Transcobalamins - genetics
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