Click Chemistry for Drug Delivery Nanosystems
ABSTRACT The purpose of this Expert Review is to discuss the impact of click chemistry in nanosized drug delivery systems. Since the introduction of the click concept by Sharpless and coworkers in 2001, numerous examples of click reactions have been reported for the preparation and functionalization...
Gespeichert in:
| Veröffentlicht in: | Pharmaceutical research 2012-01, Vol.29 (1), p.1-34 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 34 |
|---|---|
| container_issue | 1 |
| container_start_page | 1 |
| container_title | Pharmaceutical research |
| container_volume | 29 |
| creator | Lallana, Enrique Sousa-Herves, Ana Fernandez-Trillo, Francisco Riguera, Ricardo Fernandez-Megia, Eduardo |
| description | ABSTRACT
The purpose of this Expert Review is to discuss the impact of click chemistry in nanosized drug delivery systems. Since the introduction of the click concept by Sharpless and coworkers in 2001, numerous examples of click reactions have been reported for the preparation and functionalization of polymeric micelles and nanoparticles, liposomes and polymersomes, capsules, microspheres, metal and silica nanoparticles, carbon nanotubes and fullerenes, or bionanoparticles. Among these click processes, Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) has attracted most attention based on its high orthogonality, reliability, and experimental simplicity for non-specialists. A renewed interest in the use of efficient classical transformations has been also observed (
e.g.
, thiol-ene coupling, Michael addition, Diels-Alder). Special emphasis is also devoted to critically discuss the click concept, as well as practical aspects of application of CuAAC to ensure efficient and harmless bioconjugation. |
| doi_str_mv | 10.1007/s11095-011-0568-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_912813139</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2548332891</sourcerecordid><originalsourceid>FETCH-LOGICAL-c509t-844fe56b7d04e4cae4dd4e693627bb8ede624407cf5d44d95d91bba4b88944af3</originalsourceid><addsrcrecordid>eNp1kE1PwzAMhiMEYmPwA7igColjIG6dNjmiji9pggtI3KK0TUdHP0bSIu3fk6mDnThZsp_Xth5CzoFdA2PJjQNgklMGQBmPBeUHZAo8iahk-H5IpiwJkYoEYUJOnFsxxgRIPCaTECRELAqnhKZ1lX8G6YdpKtfbTVB2NpjbYRnMTV19G9951m3nNq43jTslR6WunTnb1Rl5u797TR_p4uXhKb1d0Jwz2VOBWBoeZ0nB0GCuDRYFmlhGcZhkmTCFiUNEluQlLxALyQsJWaYxE0Ii6jKakctx79p2X4NxvVp1g239SSUhFBBBJD0EI5TbzjlrSrW2VaPtRgFTWz9q9KO8H7X1o7jPXOwWD1ljir_ErxAPXO0A7XJdl1a3eeX2HOdx5K16Lhw550ft0tj9h_9f_wFQJXvv</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>912813139</pqid></control><display><type>article</type><title>Click Chemistry for Drug Delivery Nanosystems</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Lallana, Enrique ; Sousa-Herves, Ana ; Fernandez-Trillo, Francisco ; Riguera, Ricardo ; Fernandez-Megia, Eduardo</creator><creatorcontrib>Lallana, Enrique ; Sousa-Herves, Ana ; Fernandez-Trillo, Francisco ; Riguera, Ricardo ; Fernandez-Megia, Eduardo</creatorcontrib><description>ABSTRACT
The purpose of this Expert Review is to discuss the impact of click chemistry in nanosized drug delivery systems. Since the introduction of the click concept by Sharpless and coworkers in 2001, numerous examples of click reactions have been reported for the preparation and functionalization of polymeric micelles and nanoparticles, liposomes and polymersomes, capsules, microspheres, metal and silica nanoparticles, carbon nanotubes and fullerenes, or bionanoparticles. Among these click processes, Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) has attracted most attention based on its high orthogonality, reliability, and experimental simplicity for non-specialists. A renewed interest in the use of efficient classical transformations has been also observed (
e.g.
, thiol-ene coupling, Michael addition, Diels-Alder). Special emphasis is also devoted to critically discuss the click concept, as well as practical aspects of application of CuAAC to ensure efficient and harmless bioconjugation.</description><identifier>ISSN: 0724-8741</identifier><identifier>EISSN: 1573-904X</identifier><identifier>DOI: 10.1007/s11095-011-0568-5</identifier><identifier>PMID: 21913032</identifier><identifier>CODEN: PHREEB</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Alkynes - chemistry ; Antibodies - chemistry ; Azides - chemistry ; Biochemistry ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Catalysis ; Chemical reactions ; Click Chemistry ; Copper - chemistry ; Cyclization ; Drug Delivery Systems ; Expert Review ; General pharmacology ; Humans ; Lipids - chemistry ; Medical Law ; Medical sciences ; Nanomedicine ; Nanoparticles - chemistry ; Nanostructured materials ; Nucleic Acids - chemistry ; Peptides - chemistry ; Pharmaceutical sciences ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Pharmacology/Toxicology ; Pharmacy ; Polysaccharides - chemistry ; Proteins - chemistry</subject><ispartof>Pharmaceutical research, 2012-01, Vol.29 (1), p.1-34</ispartof><rights>Springer Science+Business Media, LLC 2011</rights><rights>2015 INIST-CNRS</rights><rights>Springer Science+Business Media, LLC 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-844fe56b7d04e4cae4dd4e693627bb8ede624407cf5d44d95d91bba4b88944af3</citedby><cites>FETCH-LOGICAL-c509t-844fe56b7d04e4cae4dd4e693627bb8ede624407cf5d44d95d91bba4b88944af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11095-011-0568-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11095-011-0568-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25563724$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21913032$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lallana, Enrique</creatorcontrib><creatorcontrib>Sousa-Herves, Ana</creatorcontrib><creatorcontrib>Fernandez-Trillo, Francisco</creatorcontrib><creatorcontrib>Riguera, Ricardo</creatorcontrib><creatorcontrib>Fernandez-Megia, Eduardo</creatorcontrib><title>Click Chemistry for Drug Delivery Nanosystems</title><title>Pharmaceutical research</title><addtitle>Pharm Res</addtitle><addtitle>Pharm Res</addtitle><description>ABSTRACT
The purpose of this Expert Review is to discuss the impact of click chemistry in nanosized drug delivery systems. Since the introduction of the click concept by Sharpless and coworkers in 2001, numerous examples of click reactions have been reported for the preparation and functionalization of polymeric micelles and nanoparticles, liposomes and polymersomes, capsules, microspheres, metal and silica nanoparticles, carbon nanotubes and fullerenes, or bionanoparticles. Among these click processes, Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) has attracted most attention based on its high orthogonality, reliability, and experimental simplicity for non-specialists. A renewed interest in the use of efficient classical transformations has been also observed (
e.g.
, thiol-ene coupling, Michael addition, Diels-Alder). Special emphasis is also devoted to critically discuss the click concept, as well as practical aspects of application of CuAAC to ensure efficient and harmless bioconjugation.</description><subject>Alkynes - chemistry</subject><subject>Antibodies - chemistry</subject><subject>Azides - chemistry</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Catalysis</subject><subject>Chemical reactions</subject><subject>Click Chemistry</subject><subject>Copper - chemistry</subject><subject>Cyclization</subject><subject>Drug Delivery Systems</subject><subject>Expert Review</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Lipids - chemistry</subject><subject>Medical Law</subject><subject>Medical sciences</subject><subject>Nanomedicine</subject><subject>Nanoparticles - chemistry</subject><subject>Nanostructured materials</subject><subject>Nucleic Acids - chemistry</subject><subject>Peptides - chemistry</subject><subject>Pharmaceutical sciences</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Polysaccharides - chemistry</subject><subject>Proteins - chemistry</subject><issn>0724-8741</issn><issn>1573-904X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1PwzAMhiMEYmPwA7igColjIG6dNjmiji9pggtI3KK0TUdHP0bSIu3fk6mDnThZsp_Xth5CzoFdA2PJjQNgklMGQBmPBeUHZAo8iahk-H5IpiwJkYoEYUJOnFsxxgRIPCaTECRELAqnhKZ1lX8G6YdpKtfbTVB2NpjbYRnMTV19G9951m3nNq43jTslR6WunTnb1Rl5u797TR_p4uXhKb1d0Jwz2VOBWBoeZ0nB0GCuDRYFmlhGcZhkmTCFiUNEluQlLxALyQsJWaYxE0Ii6jKakctx79p2X4NxvVp1g239SSUhFBBBJD0EI5TbzjlrSrW2VaPtRgFTWz9q9KO8H7X1o7jPXOwWD1ljir_ErxAPXO0A7XJdl1a3eeX2HOdx5K16Lhw550ft0tj9h_9f_wFQJXvv</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Lallana, Enrique</creator><creator>Sousa-Herves, Ana</creator><creator>Fernandez-Trillo, Francisco</creator><creator>Riguera, Ricardo</creator><creator>Fernandez-Megia, Eduardo</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20120101</creationdate><title>Click Chemistry for Drug Delivery Nanosystems</title><author>Lallana, Enrique ; Sousa-Herves, Ana ; Fernandez-Trillo, Francisco ; Riguera, Ricardo ; Fernandez-Megia, Eduardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-844fe56b7d04e4cae4dd4e693627bb8ede624407cf5d44d95d91bba4b88944af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Alkynes - chemistry</topic><topic>Antibodies - chemistry</topic><topic>Azides - chemistry</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Biomedicine</topic><topic>Catalysis</topic><topic>Chemical reactions</topic><topic>Click Chemistry</topic><topic>Copper - chemistry</topic><topic>Cyclization</topic><topic>Drug Delivery Systems</topic><topic>Expert Review</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Lipids - chemistry</topic><topic>Medical Law</topic><topic>Medical sciences</topic><topic>Nanomedicine</topic><topic>Nanoparticles - chemistry</topic><topic>Nanostructured materials</topic><topic>Nucleic Acids - chemistry</topic><topic>Peptides - chemistry</topic><topic>Pharmaceutical sciences</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Polysaccharides - chemistry</topic><topic>Proteins - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lallana, Enrique</creatorcontrib><creatorcontrib>Sousa-Herves, Ana</creatorcontrib><creatorcontrib>Fernandez-Trillo, Francisco</creatorcontrib><creatorcontrib>Riguera, Ricardo</creatorcontrib><creatorcontrib>Fernandez-Megia, Eduardo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Pharmaceutical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lallana, Enrique</au><au>Sousa-Herves, Ana</au><au>Fernandez-Trillo, Francisco</au><au>Riguera, Ricardo</au><au>Fernandez-Megia, Eduardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Click Chemistry for Drug Delivery Nanosystems</atitle><jtitle>Pharmaceutical research</jtitle><stitle>Pharm Res</stitle><addtitle>Pharm Res</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>29</volume><issue>1</issue><spage>1</spage><epage>34</epage><pages>1-34</pages><issn>0724-8741</issn><eissn>1573-904X</eissn><coden>PHREEB</coden><abstract>ABSTRACT
The purpose of this Expert Review is to discuss the impact of click chemistry in nanosized drug delivery systems. Since the introduction of the click concept by Sharpless and coworkers in 2001, numerous examples of click reactions have been reported for the preparation and functionalization of polymeric micelles and nanoparticles, liposomes and polymersomes, capsules, microspheres, metal and silica nanoparticles, carbon nanotubes and fullerenes, or bionanoparticles. Among these click processes, Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) has attracted most attention based on its high orthogonality, reliability, and experimental simplicity for non-specialists. A renewed interest in the use of efficient classical transformations has been also observed (
e.g.
, thiol-ene coupling, Michael addition, Diels-Alder). Special emphasis is also devoted to critically discuss the click concept, as well as practical aspects of application of CuAAC to ensure efficient and harmless bioconjugation.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>21913032</pmid><doi>10.1007/s11095-011-0568-5</doi><tpages>34</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0724-8741 |
| ispartof | Pharmaceutical research, 2012-01, Vol.29 (1), p.1-34 |
| issn | 0724-8741 1573-904X |
| language | eng |
| recordid | cdi_proquest_journals_912813139 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Alkynes - chemistry Antibodies - chemistry Azides - chemistry Biochemistry Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Catalysis Chemical reactions Click Chemistry Copper - chemistry Cyclization Drug Delivery Systems Expert Review General pharmacology Humans Lipids - chemistry Medical Law Medical sciences Nanomedicine Nanoparticles - chemistry Nanostructured materials Nucleic Acids - chemistry Peptides - chemistry Pharmaceutical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy Polysaccharides - chemistry Proteins - chemistry |
| title | Click Chemistry for Drug Delivery Nanosystems |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T15%3A09%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Click%20Chemistry%20for%20Drug%20Delivery%20Nanosystems&rft.jtitle=Pharmaceutical%20research&rft.au=Lallana,%20Enrique&rft.date=2012-01-01&rft.volume=29&rft.issue=1&rft.spage=1&rft.epage=34&rft.pages=1-34&rft.issn=0724-8741&rft.eissn=1573-904X&rft.coden=PHREEB&rft_id=info:doi/10.1007/s11095-011-0568-5&rft_dat=%3Cproquest_cross%3E2548332891%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=912813139&rft_id=info:pmid/21913032&rfr_iscdi=true |