Mutants of the Escherichia coli heat-labile enterotoxin as safe and strong adjuvants for intranasal delivery of vaccines

Cholera toxin and Escherichia coli heat-labile enterotoxin are powerful mucosal adjuvants but their high toxicity hampers their use in humans. Site-directed mutagenesis has allowed the generation of several cholera toxin and E. coli heat-labile enterotoxin mutants with abolished or strongly reduced...

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Veröffentlicht in:	Expert review of vaccines 2003-04, Vol.2 (2), p.285-293
Hauptverfasser:	Peppoloni, Samuele, Ruggiero, Paolo, Contorni, Mario, Morandi, Maurizio, Pizza, Mariagrazia, Rappuoli, Rino, Podda, Audino, Giudice, Giuseppe Del
Format:	Artikel
Sprache:	eng
Schlagworte:	adjuvants Adjuvants, Immunologic - administration & dosage Administration, Intranasal Analysis Animals Bacterial Toxins - administration & dosage Bacterial Toxins - genetics Cholera Cholera toxin Contamination Drug therapy, Combination Enterotoxins - administration & dosage Enterotoxins - genetics Enzymes Escherichia coli Escherichia coli - genetics Escherichia coli - immunology Escherichia coli Proteins Humans Immunity, Mucosal Influenza Influenza Vaccines - administration & dosage mucosal Mutation Safety Vaccines Vaccines - administration & dosage
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