Optical Diffuse Imaging of an Ex Vivo Model Cancerous Human Breast Using Independent Component Analysis

Optical imaging using independent component analysis (OPTICA) has been used for detection, 3D localization, and cross-section imaging of a tumor inside a model human breast composed of ex vivo human breast tissues. OPTICA uses a multisource target illumination and multidetector signal acquisition sc...

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Veröffentlicht in:IEEE journal of selected topics in quantum electronics 2008-01, Vol.14 (1), p.43-49
Hauptverfasser: Min Xu, Alrubaiee, M., Gayen, S.K., Alfano, R.R.
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container_title IEEE journal of selected topics in quantum electronics
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creator Min Xu
Alrubaiee, M.
Gayen, S.K.
Alfano, R.R.
description Optical imaging using independent component analysis (OPTICA) has been used for detection, 3D localization, and cross-section imaging of a tumor inside a model human breast composed of ex vivo human breast tissues. OPTICA uses a multisource target illumination and multidetector signal acquisition scheme to obtain multiple spatial and angular views of the sample for target localization. Independent component analysis of the perturbations in the spatial light intensity distribution measured on the sample boundary sorts out the signal originating from individual targets. A back-projection technique estimates the cross-section of each target. The approach correctly provided the positions of a tumor located at the mid-plane and two glandular structures located at different positions within the 33-mm thick model breast. The reconstructed cross-section images are in good agreement with known dimensions of the structures, and pathological findings.
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subjects Biomedical optical imaging
Breast
Breast cancer
Breast neoplasms
Cross sections
diffuse optical imaging
Human
Humans
Image reconstruction
Imaging
Independent component analysis
Lighting
Magnetic resonance imaging
near infrared (NIR) imaging
Optical devices
Optical imaging
optical imaging using independent component analysis (OPTICA)
optical mammography
Position (location)
Tumors
Ultrafast optics
title Optical Diffuse Imaging of an Ex Vivo Model Cancerous Human Breast Using Independent Component Analysis
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