Optical Diffuse Imaging of an Ex Vivo Model Cancerous Human Breast Using Independent Component Analysis
Optical imaging using independent component analysis (OPTICA) has been used for detection, 3D localization, and cross-section imaging of a tumor inside a model human breast composed of ex vivo human breast tissues. OPTICA uses a multisource target illumination and multidetector signal acquisition sc...
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Veröffentlicht in: | IEEE journal of selected topics in quantum electronics 2008-01, Vol.14 (1), p.43-49 |
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creator | Min Xu Alrubaiee, M. Gayen, S.K. Alfano, R.R. |
description | Optical imaging using independent component analysis (OPTICA) has been used for detection, 3D localization, and cross-section imaging of a tumor inside a model human breast composed of ex vivo human breast tissues. OPTICA uses a multisource target illumination and multidetector signal acquisition scheme to obtain multiple spatial and angular views of the sample for target localization. Independent component analysis of the perturbations in the spatial light intensity distribution measured on the sample boundary sorts out the signal originating from individual targets. A back-projection technique estimates the cross-section of each target. The approach correctly provided the positions of a tumor located at the mid-plane and two glandular structures located at different positions within the 33-mm thick model breast. The reconstructed cross-section images are in good agreement with known dimensions of the structures, and pathological findings. |
doi_str_mv | 10.1109/JSTQE.2007.912831 |
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OPTICA uses a multisource target illumination and multidetector signal acquisition scheme to obtain multiple spatial and angular views of the sample for target localization. Independent component analysis of the perturbations in the spatial light intensity distribution measured on the sample boundary sorts out the signal originating from individual targets. A back-projection technique estimates the cross-section of each target. The approach correctly provided the positions of a tumor located at the mid-plane and two glandular structures located at different positions within the 33-mm thick model breast. The reconstructed cross-section images are in good agreement with known dimensions of the structures, and pathological findings.</description><identifier>ISSN: 1077-260X</identifier><identifier>EISSN: 1558-4542</identifier><identifier>DOI: 10.1109/JSTQE.2007.912831</identifier><identifier>CODEN: IJSQEN</identifier><language>eng</language><publisher>New York: IEEE</publisher><subject>Biomedical optical imaging ; Breast ; Breast cancer ; Breast neoplasms ; Cross sections ; diffuse optical imaging ; Human ; Humans ; Image reconstruction ; Imaging ; Independent component analysis ; Lighting ; Magnetic resonance imaging ; near infrared (NIR) imaging ; Optical devices ; Optical imaging ; optical imaging using independent component analysis (OPTICA) ; optical mammography ; Position (location) ; Tumors ; Ultrafast optics</subject><ispartof>IEEE journal of selected topics in quantum electronics, 2008-01, Vol.14 (1), p.43-49</ispartof><rights>Copyright The Institute of Electrical and Electronics Engineers, Inc. (IEEE) 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-1c3fe6bbbe632cdc12d789535b0aa007cac297d7d87d347e827395f96d3652d03</citedby><cites>FETCH-LOGICAL-c356t-1c3fe6bbbe632cdc12d789535b0aa007cac297d7d87d347e827395f96d3652d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/4451139$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>314,776,780,792,27903,27904,54737</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/4451139$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc></links><search><creatorcontrib>Min Xu</creatorcontrib><creatorcontrib>Alrubaiee, M.</creatorcontrib><creatorcontrib>Gayen, S.K.</creatorcontrib><creatorcontrib>Alfano, R.R.</creatorcontrib><title>Optical Diffuse Imaging of an Ex Vivo Model Cancerous Human Breast Using Independent Component Analysis</title><title>IEEE journal of selected topics in quantum electronics</title><addtitle>JSTQE</addtitle><description>Optical imaging using independent component analysis (OPTICA) has been used for detection, 3D localization, and cross-section imaging of a tumor inside a model human breast composed of ex vivo human breast tissues. OPTICA uses a multisource target illumination and multidetector signal acquisition scheme to obtain multiple spatial and angular views of the sample for target localization. Independent component analysis of the perturbations in the spatial light intensity distribution measured on the sample boundary sorts out the signal originating from individual targets. A back-projection technique estimates the cross-section of each target. The approach correctly provided the positions of a tumor located at the mid-plane and two glandular structures located at different positions within the 33-mm thick model breast. The reconstructed cross-section images are in good agreement with known dimensions of the structures, and pathological findings.</description><subject>Biomedical optical imaging</subject><subject>Breast</subject><subject>Breast cancer</subject><subject>Breast neoplasms</subject><subject>Cross sections</subject><subject>diffuse optical imaging</subject><subject>Human</subject><subject>Humans</subject><subject>Image reconstruction</subject><subject>Imaging</subject><subject>Independent component analysis</subject><subject>Lighting</subject><subject>Magnetic resonance imaging</subject><subject>near infrared (NIR) imaging</subject><subject>Optical devices</subject><subject>Optical imaging</subject><subject>optical imaging using independent component analysis (OPTICA)</subject><subject>optical mammography</subject><subject>Position (location)</subject><subject>Tumors</subject><subject>Ultrafast optics</subject><issn>1077-260X</issn><issn>1558-4542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>RIE</sourceid><recordid>eNp9kU1LxDAQhoMoqKs_QLwED-Klaz6apD3quuqKIuIH3kI2mS6VtqlNK-6_N-uKBw9eZgbmeYeZeRE6oGRMKclPbx6fHqZjRoga55RlnG6gHSpElqQiZZuxJkolTJLXbbQbwhshJEszsoMW921fWlPhi7IohgB4VptF2SywL7Bp8PQTv5QfHt95BxWemMZC54eAr4c6ds87MKHHz2ElmDUOWoih6fHE161vVtVZY6plKMMe2ipMFWD_J4_Q8-X0aXKd3N5fzSZnt4nlQvYJtbwAOZ_PQXJmnaXMqSwXXMyJMfE4ayzLlVMuU46nCjKmeC6KXDouBXOEj9Dxem7b-fcBQq_rMlioKtNAXFxzyblUJIvgyb8glYpyItIYR-joD_rmhy4eFnT8NUsFESxCdA3ZzofQQaHbrqxNt9SU6JVF-tsivbJIry2KmsO1pgSAXz5NBaU8519g-IxG</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Min Xu</creator><creator>Alrubaiee, M.</creator><creator>Gayen, S.K.</creator><creator>Alfano, R.R.</creator><general>IEEE</general><general>The Institute of Electrical and Electronics Engineers, Inc. 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OPTICA uses a multisource target illumination and multidetector signal acquisition scheme to obtain multiple spatial and angular views of the sample for target localization. Independent component analysis of the perturbations in the spatial light intensity distribution measured on the sample boundary sorts out the signal originating from individual targets. A back-projection technique estimates the cross-section of each target. The approach correctly provided the positions of a tumor located at the mid-plane and two glandular structures located at different positions within the 33-mm thick model breast. The reconstructed cross-section images are in good agreement with known dimensions of the structures, and pathological findings.</abstract><cop>New York</cop><pub>IEEE</pub><doi>10.1109/JSTQE.2007.912831</doi><tpages>7</tpages></addata></record> |
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subjects | Biomedical optical imaging Breast Breast cancer Breast neoplasms Cross sections diffuse optical imaging Human Humans Image reconstruction Imaging Independent component analysis Lighting Magnetic resonance imaging near infrared (NIR) imaging Optical devices Optical imaging optical imaging using independent component analysis (OPTICA) optical mammography Position (location) Tumors Ultrafast optics |
title | Optical Diffuse Imaging of an Ex Vivo Model Cancerous Human Breast Using Independent Component Analysis |
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