Polymer microring resonators for biochemical sensing applications
Polymer microring resonators were demonstrated for sensing biomolecules without using fluorescent labels. The microring devices, fabricated by a direct imprinting technique, possess high Q factors of /spl sim/20000. This feature provides high sensitivity and a low detection limit for biochemical sen...
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| Veröffentlicht in: | IEEE journal of selected topics in quantum electronics 2006-01, Vol.12 (1), p.134-142 |
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| creator | Chung-Yen Chao Fung, W. Guo, L.J. |
| description | Polymer microring resonators were demonstrated for sensing biomolecules without using fluorescent labels. The microring devices, fabricated by a direct imprinting technique, possess high Q factors of /spl sim/20000. This feature provides high sensitivity and a low detection limit for biochemical sensing applications. With these properties, the devices were used to detect and quantify the biomolecules present either in a homogeneous solution that surrounds the microring waveguide (homogeneous sensing) or specifically bound on the waveguide surface (surface sensing). In the former sensing mechanism, the current devices can detect an effective index change of 10/sup -7/ refractive index units (RIU); in the latter, they can reach a detection limit of /spl sim/250 pg/mm/sup 2/ of biomolecular coverage on the microring surface. In addition, the experiments show that the devices can detect both small and large biomolecules. |
| doi_str_mv | 10.1109/JSTQE.2005.862945 |
| format | Article |
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The microring devices, fabricated by a direct imprinting technique, possess high Q factors of /spl sim/20000. This feature provides high sensitivity and a low detection limit for biochemical sensing applications. With these properties, the devices were used to detect and quantify the biomolecules present either in a homogeneous solution that surrounds the microring waveguide (homogeneous sensing) or specifically bound on the waveguide surface (surface sensing). In the former sensing mechanism, the current devices can detect an effective index change of 10/sup -7/ refractive index units (RIU); in the latter, they can reach a detection limit of /spl sim/250 pg/mm/sup 2/ of biomolecular coverage on the microring surface. In addition, the experiments show that the devices can detect both small and large biomolecules.</description><identifier>ISSN: 1077-260X</identifier><identifier>EISSN: 1558-4542</identifier><identifier>DOI: 10.1109/JSTQE.2005.862945</identifier><identifier>CODEN: IJSQEN</identifier><language>eng</language><publisher>New York: IEEE</publisher><subject>Biochemical sensors ; Biochemistry ; Biomolecules ; biosensors ; Chemical sensors ; Detection ; Devices ; integrated optics ; microresonator ; microring ; microring resonator ; Molecular biophysics ; nanoimprint ; Optical resonators ; Optical sensors ; Optical surface waves ; Optical waveguides ; Polymers ; Q factor ; Q factors ; Quantum electronics ; Resonance ; Resonators ; Surface waves ; waveguide ; Waveguides</subject><ispartof>IEEE journal of selected topics in quantum electronics, 2006-01, Vol.12 (1), p.134-142</ispartof><rights>Copyright The Institute of Electrical and Electronics Engineers, Inc. (IEEE) 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-387056cee741b566dabb22ccfe313dede875525d06d23dfbbdc8010acbd790413</citedby><cites>FETCH-LOGICAL-c421t-387056cee741b566dabb22ccfe313dede875525d06d23dfbbdc8010acbd790413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/1588892$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>314,780,784,796,27924,27925,54758</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/1588892$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc></links><search><creatorcontrib>Chung-Yen Chao</creatorcontrib><creatorcontrib>Fung, W.</creatorcontrib><creatorcontrib>Guo, L.J.</creatorcontrib><title>Polymer microring resonators for biochemical sensing applications</title><title>IEEE journal of selected topics in quantum electronics</title><addtitle>JSTQE</addtitle><description>Polymer microring resonators were demonstrated for sensing biomolecules without using fluorescent labels. The microring devices, fabricated by a direct imprinting technique, possess high Q factors of /spl sim/20000. This feature provides high sensitivity and a low detection limit for biochemical sensing applications. With these properties, the devices were used to detect and quantify the biomolecules present either in a homogeneous solution that surrounds the microring waveguide (homogeneous sensing) or specifically bound on the waveguide surface (surface sensing). In the former sensing mechanism, the current devices can detect an effective index change of 10/sup -7/ refractive index units (RIU); in the latter, they can reach a detection limit of /spl sim/250 pg/mm/sup 2/ of biomolecular coverage on the microring surface. In addition, the experiments show that the devices can detect both small and large biomolecules.</description><subject>Biochemical sensors</subject><subject>Biochemistry</subject><subject>Biomolecules</subject><subject>biosensors</subject><subject>Chemical sensors</subject><subject>Detection</subject><subject>Devices</subject><subject>integrated optics</subject><subject>microresonator</subject><subject>microring</subject><subject>microring resonator</subject><subject>Molecular biophysics</subject><subject>nanoimprint</subject><subject>Optical resonators</subject><subject>Optical sensors</subject><subject>Optical surface waves</subject><subject>Optical waveguides</subject><subject>Polymers</subject><subject>Q factor</subject><subject>Q factors</subject><subject>Quantum electronics</subject><subject>Resonance</subject><subject>Resonators</subject><subject>Surface waves</subject><subject>waveguide</subject><subject>Waveguides</subject><issn>1077-260X</issn><issn>1558-4542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>RIE</sourceid><recordid>eNp9kE1LxDAQhoMouK7-APFSPOip6yRp0vS4LOsXgooreAttOtUubVOT7mH_vVkrCB48zTDzvAPzEHJKYUYpZFf3L6vn5YwBiJmSLEvEHplQIVSciITthx7SNGYS3g7JkfdrAFCJggmZP9lm26KL2to46-ruPXLobZcP1vmosi4qams-MKzzJvLY-R2S930TBkNtO39MDqq88XjyU6fk9Xq5WtzGD483d4v5Q2wSRoeYqxSENIhpQgshZZkXBWPGVMgpL7FElQrBRAmyZLysiqI0CijkpijTDBLKp-RyvNs7-7lBP-i29gabJu_QbrxWmaQq44IH8uJfkingEoQI4PkfcG03rgtf6IwySmkmkwDREQp-vHdY6d7Vbe62moLeudff7vXOvR7dh8zZmKkR8ZcXSqmM8S_XNoDD</recordid><startdate>200601</startdate><enddate>200601</enddate><creator>Chung-Yen Chao</creator><creator>Fung, W.</creator><creator>Guo, L.J.</creator><general>IEEE</general><general>The Institute of Electrical and Electronics Engineers, Inc. (IEEE)</general><scope>97E</scope><scope>RIA</scope><scope>RIE</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>F28</scope><scope>FR3</scope></search><sort><creationdate>200601</creationdate><title>Polymer microring resonators for biochemical sensing applications</title><author>Chung-Yen Chao ; Fung, W. ; Guo, L.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-387056cee741b566dabb22ccfe313dede875525d06d23dfbbdc8010acbd790413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biochemical sensors</topic><topic>Biochemistry</topic><topic>Biomolecules</topic><topic>biosensors</topic><topic>Chemical sensors</topic><topic>Detection</topic><topic>Devices</topic><topic>integrated optics</topic><topic>microresonator</topic><topic>microring</topic><topic>microring resonator</topic><topic>Molecular biophysics</topic><topic>nanoimprint</topic><topic>Optical resonators</topic><topic>Optical sensors</topic><topic>Optical surface waves</topic><topic>Optical waveguides</topic><topic>Polymers</topic><topic>Q factor</topic><topic>Q factors</topic><topic>Quantum electronics</topic><topic>Resonance</topic><topic>Resonators</topic><topic>Surface waves</topic><topic>waveguide</topic><topic>Waveguides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung-Yen Chao</creatorcontrib><creatorcontrib>Fung, W.</creatorcontrib><creatorcontrib>Guo, L.J.</creatorcontrib><collection>IEEE All-Society Periodicals Package (ASPP) 2005-present</collection><collection>IEEE All-Society Periodicals Package (ASPP) 1998-Present</collection><collection>IEEE Electronic Library (IEL)</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><jtitle>IEEE journal of selected topics in quantum electronics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Chung-Yen Chao</au><au>Fung, W.</au><au>Guo, L.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymer microring resonators for biochemical sensing applications</atitle><jtitle>IEEE journal of selected topics in quantum electronics</jtitle><stitle>JSTQE</stitle><date>2006-01</date><risdate>2006</risdate><volume>12</volume><issue>1</issue><spage>134</spage><epage>142</epage><pages>134-142</pages><issn>1077-260X</issn><eissn>1558-4542</eissn><coden>IJSQEN</coden><abstract>Polymer microring resonators were demonstrated for sensing biomolecules without using fluorescent labels. The microring devices, fabricated by a direct imprinting technique, possess high Q factors of /spl sim/20000. This feature provides high sensitivity and a low detection limit for biochemical sensing applications. With these properties, the devices were used to detect and quantify the biomolecules present either in a homogeneous solution that surrounds the microring waveguide (homogeneous sensing) or specifically bound on the waveguide surface (surface sensing). In the former sensing mechanism, the current devices can detect an effective index change of 10/sup -7/ refractive index units (RIU); in the latter, they can reach a detection limit of /spl sim/250 pg/mm/sup 2/ of biomolecular coverage on the microring surface. In addition, the experiments show that the devices can detect both small and large biomolecules.</abstract><cop>New York</cop><pub>IEEE</pub><doi>10.1109/JSTQE.2005.862945</doi><tpages>9</tpages></addata></record> |
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| source | IEEE Electronic Library (IEL) |
| subjects | Biochemical sensors Biochemistry Biomolecules biosensors Chemical sensors Detection Devices integrated optics microresonator microring microring resonator Molecular biophysics nanoimprint Optical resonators Optical sensors Optical surface waves Optical waveguides Polymers Q factor Q factors Quantum electronics Resonance Resonators Surface waves waveguide Waveguides |
| title | Polymer microring resonators for biochemical sensing applications |
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