Palmitic acid in the sn-2 position of triacylglycerols acutely influences postprandial lipid metabolism
The triacylglycerol structure of saturated fats may influence postprandial lipemia. We tested the hypothesis that high-fat meals rich in palmitic acid (16:0) in the sn-2 position decrease lipemia. Postprandial changes in plasma lipids, apolipoprotein B48, and cytokines were compared in healthy men (...
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| Veröffentlicht in: | The American journal of clinical nutrition 2011-12, Vol.94 (6), p.1433-1441 |
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| creator | SANDERS, Thomas A. B FILIPPOU, Androulla BERRY, Sarah E BAUMGARTNER, Sabine MENSINK, Ronald P |
| description | The triacylglycerol structure of saturated fats may influence postprandial lipemia.
We tested the hypothesis that high-fat meals rich in palmitic acid (16:0) in the sn-2 position decrease lipemia.
Postprandial changes in plasma lipids, apolipoprotein B48, and cytokines were compared in healthy men (n = 25) and women (n = 25) by using a randomized crossover design after meals that provided 50 g fat supplied as high-oleic sunflower oil (control), palm olein (PO), interesterified palm olein (IPO), and lard containing 0.6, 9.2, 39.1, and 70.5 mol% 16:0, respectively, at sn-2.
The sn-2-rich meals elicited different postprandial responses in plasma concentrations of nonesterified fatty acid (meal × time, P = 0.00014), triacylglycerol (meal × time, P = 0.002), and apolipoprotein B48 (meal × time × sex, P = 0.008). Nonesterified fatty acid concentrations were lower up to 3 h after lard and IPO meals than after control or PO meals. Triacylglycerol increased less steeply after lard and IPO meals than after control and PO meals; the incremental AUCs (iAUCs) were 34% (95% CI: 7%, 124%; P < 0.05) and 26% (95% CI: 16%, 132%; P < 0.05) lower after lard than after control and PO meals, respectively. In men, the maximal increment in apolipoprotein B48 was 14% (95% CI: 3%, 25%; P < 0.05) and 16% (95% CI: 2%, 30%; P < 0.05) lower for lard and IPO, respectively, compared with control. The postprandial iAUC in triacylglycerol was 51% lower in women (P = 0.001) than in men. Plasma IL-6 increased postprandially, but IL-8, TNF-α, and E-selectin decreased after all meals.
Fats with a higher proportion of palmitic acid in the sn-2 position decrease postprandial lipemia in healthy subjects. This trial was registered at controlled-trials.com as ISRCTN20774126. |
| doi_str_mv | 10.3945/ajcn.111.017459 |
| format | Article |
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We tested the hypothesis that high-fat meals rich in palmitic acid (16:0) in the sn-2 position decrease lipemia.
Postprandial changes in plasma lipids, apolipoprotein B48, and cytokines were compared in healthy men (n = 25) and women (n = 25) by using a randomized crossover design after meals that provided 50 g fat supplied as high-oleic sunflower oil (control), palm olein (PO), interesterified palm olein (IPO), and lard containing 0.6, 9.2, 39.1, and 70.5 mol% 16:0, respectively, at sn-2.
The sn-2-rich meals elicited different postprandial responses in plasma concentrations of nonesterified fatty acid (meal × time, P = 0.00014), triacylglycerol (meal × time, P = 0.002), and apolipoprotein B48 (meal × time × sex, P = 0.008). Nonesterified fatty acid concentrations were lower up to 3 h after lard and IPO meals than after control or PO meals. Triacylglycerol increased less steeply after lard and IPO meals than after control and PO meals; the incremental AUCs (iAUCs) were 34% (95% CI: 7%, 124%; P < 0.05) and 26% (95% CI: 16%, 132%; P < 0.05) lower after lard than after control and PO meals, respectively. In men, the maximal increment in apolipoprotein B48 was 14% (95% CI: 3%, 25%; P < 0.05) and 16% (95% CI: 2%, 30%; P < 0.05) lower for lard and IPO, respectively, compared with control. The postprandial iAUC in triacylglycerol was 51% lower in women (P = 0.001) than in men. Plasma IL-6 increased postprandially, but IL-8, TNF-α, and E-selectin decreased after all meals.
Fats with a higher proportion of palmitic acid in the sn-2 position decrease postprandial lipemia in healthy subjects. This trial was registered at controlled-trials.com as ISRCTN20774126.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.3945/ajcn.111.017459</identifier><identifier>PMID: 22030225</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Nutrition</publisher><subject>Adolescent ; Adult ; Apolipoproteins B - blood ; Area Under Curve ; Arecaceae - chemistry ; Biological and medical sciences ; Body fat ; Cross-Over Studies ; Cytokines - blood ; Dietary Fats - blood ; Dietary Fats - pharmacology ; Double-Blind Method ; E-Selectin - blood ; Fatty Acids - pharmacology ; Fatty Acids - therapeutic use ; Fatty Acids, Nonesterified - blood ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Hyperlipidemias - blood ; Hyperlipidemias - prevention & control ; Lipid Metabolism - drug effects ; Lipids ; Male ; Metabolism ; Oleic Acid - pharmacology ; Oleic Acid - therapeutic use ; Palmitic Acid - pharmacology ; Palmitic Acid - therapeutic use ; Postprandial Period ; Reference Values ; Sex Factors ; Triglycerides ; Triglycerides - blood ; Triglycerides - chemistry ; Triglycerides - pharmacology ; Vegetable oils ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Young Adult</subject><ispartof>The American journal of clinical nutrition, 2011-12, Vol.94 (6), p.1433-1441</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Dec 1, 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-b779750e6230b610c61daa90bd5556171e769101575b3af36242688717a36e8d3</citedby><cites>FETCH-LOGICAL-c460t-b779750e6230b610c61daa90bd5556171e769101575b3af36242688717a36e8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25229062$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22030225$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SANDERS, Thomas A. B</creatorcontrib><creatorcontrib>FILIPPOU, Androulla</creatorcontrib><creatorcontrib>BERRY, Sarah E</creatorcontrib><creatorcontrib>BAUMGARTNER, Sabine</creatorcontrib><creatorcontrib>MENSINK, Ronald P</creatorcontrib><title>Palmitic acid in the sn-2 position of triacylglycerols acutely influences postprandial lipid metabolism</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>The triacylglycerol structure of saturated fats may influence postprandial lipemia.
We tested the hypothesis that high-fat meals rich in palmitic acid (16:0) in the sn-2 position decrease lipemia.
Postprandial changes in plasma lipids, apolipoprotein B48, and cytokines were compared in healthy men (n = 25) and women (n = 25) by using a randomized crossover design after meals that provided 50 g fat supplied as high-oleic sunflower oil (control), palm olein (PO), interesterified palm olein (IPO), and lard containing 0.6, 9.2, 39.1, and 70.5 mol% 16:0, respectively, at sn-2.
The sn-2-rich meals elicited different postprandial responses in plasma concentrations of nonesterified fatty acid (meal × time, P = 0.00014), triacylglycerol (meal × time, P = 0.002), and apolipoprotein B48 (meal × time × sex, P = 0.008). Nonesterified fatty acid concentrations were lower up to 3 h after lard and IPO meals than after control or PO meals. Triacylglycerol increased less steeply after lard and IPO meals than after control and PO meals; the incremental AUCs (iAUCs) were 34% (95% CI: 7%, 124%; P < 0.05) and 26% (95% CI: 16%, 132%; P < 0.05) lower after lard than after control and PO meals, respectively. In men, the maximal increment in apolipoprotein B48 was 14% (95% CI: 3%, 25%; P < 0.05) and 16% (95% CI: 2%, 30%; P < 0.05) lower for lard and IPO, respectively, compared with control. The postprandial iAUC in triacylglycerol was 51% lower in women (P = 0.001) than in men. Plasma IL-6 increased postprandially, but IL-8, TNF-α, and E-selectin decreased after all meals.
Fats with a higher proportion of palmitic acid in the sn-2 position decrease postprandial lipemia in healthy subjects. This trial was registered at controlled-trials.com as ISRCTN20774126.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Apolipoproteins B - blood</subject><subject>Area Under Curve</subject><subject>Arecaceae - chemistry</subject><subject>Biological and medical sciences</subject><subject>Body fat</subject><subject>Cross-Over Studies</subject><subject>Cytokines - blood</subject><subject>Dietary Fats - blood</subject><subject>Dietary Fats - pharmacology</subject><subject>Double-Blind Method</subject><subject>E-Selectin - blood</subject><subject>Fatty Acids - pharmacology</subject><subject>Fatty Acids - therapeutic use</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hyperlipidemias - blood</subject><subject>Hyperlipidemias - prevention & control</subject><subject>Lipid Metabolism - drug effects</subject><subject>Lipids</subject><subject>Male</subject><subject>Metabolism</subject><subject>Oleic Acid - pharmacology</subject><subject>Oleic Acid - therapeutic use</subject><subject>Palmitic Acid - pharmacology</subject><subject>Palmitic Acid - therapeutic use</subject><subject>Postprandial Period</subject><subject>Reference Values</subject><subject>Sex Factors</subject><subject>Triglycerides</subject><subject>Triglycerides - blood</subject><subject>Triglycerides - chemistry</subject><subject>Triglycerides - pharmacology</subject><subject>Vegetable oils</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Young Adult</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkDtPwzAUhS0EoqUws6EIiTHttR3b8YgQL6kSDDBbjuMUV84DOxn673HVAtMd7nfOkT6ErjEsqSzYSm9Nt8QYLwGLgskTNMeSljklIE7RHABILjFnM3QR4xYAk6Lk52hGCFAghM3R5l371o3OZNq4OnNdNn7ZLHY5yYY-pkffZX2TjcFps_MbvzM29D4mehqt36VA4yfbGRv3_DgE3dVO-8y7IdW1dtRV711sL9FZo320V8e7QJ9Pjx8PL_n67fn14X6dm4LDmFdCSMHAckKh4hgMx7XWEqqaMcaxwFZwiQEzwSqqG8pJQXhZCiw05bas6QLdHnqH0H9PNo5q20-hS5NKAqecMSEStDpAJvQxBtuoIbhWh53CoPZe1d6rSl7VwWtK3Bxrp6q19R__KzIBd0dAR6N9kzwYF_85RkjaJ_QHiFSAhg</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>SANDERS, Thomas A. B</creator><creator>FILIPPOU, Androulla</creator><creator>BERRY, Sarah E</creator><creator>BAUMGARTNER, Sabine</creator><creator>MENSINK, Ronald P</creator><general>American Society for Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope></search><sort><creationdate>20111201</creationdate><title>Palmitic acid in the sn-2 position of triacylglycerols acutely influences postprandial lipid metabolism</title><author>SANDERS, Thomas A. 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Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hyperlipidemias - blood</topic><topic>Hyperlipidemias - prevention & control</topic><topic>Lipid Metabolism - drug effects</topic><topic>Lipids</topic><topic>Male</topic><topic>Metabolism</topic><topic>Oleic Acid - pharmacology</topic><topic>Oleic Acid - therapeutic use</topic><topic>Palmitic Acid - pharmacology</topic><topic>Palmitic Acid - therapeutic use</topic><topic>Postprandial Period</topic><topic>Reference Values</topic><topic>Sex Factors</topic><topic>Triglycerides</topic><topic>Triglycerides - blood</topic><topic>Triglycerides - chemistry</topic><topic>Triglycerides - pharmacology</topic><topic>Vegetable oils</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SANDERS, Thomas A. B</creatorcontrib><creatorcontrib>FILIPPOU, Androulla</creatorcontrib><creatorcontrib>BERRY, Sarah E</creatorcontrib><creatorcontrib>BAUMGARTNER, Sabine</creatorcontrib><creatorcontrib>MENSINK, Ronald P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SANDERS, Thomas A. B</au><au>FILIPPOU, Androulla</au><au>BERRY, Sarah E</au><au>BAUMGARTNER, Sabine</au><au>MENSINK, Ronald P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Palmitic acid in the sn-2 position of triacylglycerols acutely influences postprandial lipid metabolism</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>94</volume><issue>6</issue><spage>1433</spage><epage>1441</epage><pages>1433-1441</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>The triacylglycerol structure of saturated fats may influence postprandial lipemia.
We tested the hypothesis that high-fat meals rich in palmitic acid (16:0) in the sn-2 position decrease lipemia.
Postprandial changes in plasma lipids, apolipoprotein B48, and cytokines were compared in healthy men (n = 25) and women (n = 25) by using a randomized crossover design after meals that provided 50 g fat supplied as high-oleic sunflower oil (control), palm olein (PO), interesterified palm olein (IPO), and lard containing 0.6, 9.2, 39.1, and 70.5 mol% 16:0, respectively, at sn-2.
The sn-2-rich meals elicited different postprandial responses in plasma concentrations of nonesterified fatty acid (meal × time, P = 0.00014), triacylglycerol (meal × time, P = 0.002), and apolipoprotein B48 (meal × time × sex, P = 0.008). Nonesterified fatty acid concentrations were lower up to 3 h after lard and IPO meals than after control or PO meals. Triacylglycerol increased less steeply after lard and IPO meals than after control and PO meals; the incremental AUCs (iAUCs) were 34% (95% CI: 7%, 124%; P < 0.05) and 26% (95% CI: 16%, 132%; P < 0.05) lower after lard than after control and PO meals, respectively. In men, the maximal increment in apolipoprotein B48 was 14% (95% CI: 3%, 25%; P < 0.05) and 16% (95% CI: 2%, 30%; P < 0.05) lower for lard and IPO, respectively, compared with control. The postprandial iAUC in triacylglycerol was 51% lower in women (P = 0.001) than in men. Plasma IL-6 increased postprandially, but IL-8, TNF-α, and E-selectin decreased after all meals.
Fats with a higher proportion of palmitic acid in the sn-2 position decrease postprandial lipemia in healthy subjects. This trial was registered at controlled-trials.com as ISRCTN20774126.</abstract><cop>Bethesda, MD</cop><pub>American Society for Nutrition</pub><pmid>22030225</pmid><doi>10.3945/ajcn.111.017459</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The American journal of clinical nutrition, 2011-12, Vol.94 (6), p.1433-1441 |
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| subjects | Adolescent Adult Apolipoproteins B - blood Area Under Curve Arecaceae - chemistry Biological and medical sciences Body fat Cross-Over Studies Cytokines - blood Dietary Fats - blood Dietary Fats - pharmacology Double-Blind Method E-Selectin - blood Fatty Acids - pharmacology Fatty Acids - therapeutic use Fatty Acids, Nonesterified - blood Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans Hyperlipidemias - blood Hyperlipidemias - prevention & control Lipid Metabolism - drug effects Lipids Male Metabolism Oleic Acid - pharmacology Oleic Acid - therapeutic use Palmitic Acid - pharmacology Palmitic Acid - therapeutic use Postprandial Period Reference Values Sex Factors Triglycerides Triglycerides - blood Triglycerides - chemistry Triglycerides - pharmacology Vegetable oils Vertebrates: anatomy and physiology, studies on body, several organs or systems Young Adult |
| title | Palmitic acid in the sn-2 position of triacylglycerols acutely influences postprandial lipid metabolism |
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