An Association Study of −1131T>C Single Nucleotide Polymorphism of Apolipoprotein A5 Gene With Coronary Artery Disease

There are contrasting reports from different ethnical groups on the role of -1131T>C single nucleotide polymorphisms (SNPs) in the promoter region of the apolipoprotein A5 (APOA5) gene on the development of coronary artery disease (CAD). Here we have studied this association in a sample of the Iranian population. Seventy-three angiographically confirmed patients with CAD and 55 healthy individuals were entered into this study. The cases and controls were matched for demographic and serum biochemical parameters. Genotyping for the -1131T>C polymorphism of the APOA5 gene was performed using the mismatch polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. There was no association between genotype frequencies or frequency of T (major) and C (minor) alleles with CAD. However, presence of the C allele was significantly associated with the risk of development of hypertriglyceridemia. Our data did not confirm the APOA5 -1131T>C variant as a risk factor for development of CAD in our sample of Iranians.