Extracorporeal shockwave-induced expression of lubricin in tendons and septa
Lubricin, a lubricating glycoprotein that facilitates tendon gliding, is upregulated by mechanical as well as biochemical stimuli, prompting this study of its induction by extracorporeal shockwave therapy (ESWT). The objective of this study was to characterize and quantify the effect of ESWT on lubr...
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| Veröffentlicht in: | Cell and tissue research 2011-11, Vol.346 (2), p.255-262 |
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| creator | Zhang, Dafang Kearney, Cathal J. Cheriyan, Thomas Schmid, Thomas M. Spector, Myron |
| description | Lubricin, a lubricating glycoprotein that facilitates tendon gliding, is upregulated by mechanical as well as biochemical stimuli, prompting this study of its induction by extracorporeal shockwave therapy (ESWT). The objective of this study was to characterize and quantify the effect of ESWT on lubricin expression in tendons and septa in a rat model. Hindlimbs of six rats were treated with low-dose ESWT and those of another six with high-dose ESWT, using contralateral limbs as controls. After 4 days, resected samples were processed for immunolocalization of lubricin using a purified monoclonal antibody. ESWT was found to increase lubricin expression in both low-dose and high-dose ESWT-treated tendons and also in septa. Lubricin expression generally increased with increasing dose of ESWT. Increased lubricin expression may contribute to the beneficial effects of ESWT in providing pain and symptom relief in musculoskeletal disorders by decreasing erosive wear. |
| doi_str_mv | 10.1007/s00441-011-1258-7 |
| format | Article |
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The objective of this study was to characterize and quantify the effect of ESWT on lubricin expression in tendons and septa in a rat model. Hindlimbs of six rats were treated with low-dose ESWT and those of another six with high-dose ESWT, using contralateral limbs as controls. After 4 days, resected samples were processed for immunolocalization of lubricin using a purified monoclonal antibody. ESWT was found to increase lubricin expression in both low-dose and high-dose ESWT-treated tendons and also in septa. Lubricin expression generally increased with increasing dose of ESWT. Increased lubricin expression may contribute to the beneficial effects of ESWT in providing pain and symptom relief in musculoskeletal disorders by decreasing erosive wear.</description><identifier>ISSN: 0302-766X</identifier><identifier>EISSN: 1432-0878</identifier><identifier>DOI: 10.1007/s00441-011-1258-7</identifier><identifier>PMID: 22009294</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Analysis ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Cellular biology ; Extracellular Matrix - metabolism ; Gene expression ; Glycoproteins ; Glycoproteins - metabolism ; High-Energy Shock Waves ; Hindlimb - anatomy & histology ; Hindlimb - cytology ; Hindlimb - metabolism ; Human Genetics ; Intracellular Space - metabolism ; Male ; Molecular Medicine ; Monoclonal antibodies ; Proteomics ; Rats ; Rats, Sprague-Dawley ; Regular Article ; Rodents ; Staining and Labeling ; Tendons ; Tendons - cytology ; Tendons - metabolism</subject><ispartof>Cell and tissue research, 2011-11, Vol.346 (2), p.255-262</ispartof><rights>Springer-Verlag 2011</rights><rights>COPYRIGHT 2011 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-30ffcf82b7752eb43f6b39a3d049c5dcad7b6bcc5f005f062147a57fdddcf7f73</citedby><cites>FETCH-LOGICAL-c436t-30ffcf82b7752eb43f6b39a3d049c5dcad7b6bcc5f005f062147a57fdddcf7f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00441-011-1258-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00441-011-1258-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22009294$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Dafang</creatorcontrib><creatorcontrib>Kearney, Cathal J.</creatorcontrib><creatorcontrib>Cheriyan, Thomas</creatorcontrib><creatorcontrib>Schmid, Thomas M.</creatorcontrib><creatorcontrib>Spector, Myron</creatorcontrib><title>Extracorporeal shockwave-induced expression of lubricin in tendons and septa</title><title>Cell and tissue research</title><addtitle>Cell Tissue Res</addtitle><addtitle>Cell Tissue Res</addtitle><description>Lubricin, a lubricating glycoprotein that facilitates tendon gliding, is upregulated by mechanical as well as biochemical stimuli, prompting this study of its induction by extracorporeal shockwave therapy (ESWT). The objective of this study was to characterize and quantify the effect of ESWT on lubricin expression in tendons and septa in a rat model. Hindlimbs of six rats were treated with low-dose ESWT and those of another six with high-dose ESWT, using contralateral limbs as controls. After 4 days, resected samples were processed for immunolocalization of lubricin using a purified monoclonal antibody. ESWT was found to increase lubricin expression in both low-dose and high-dose ESWT-treated tendons and also in septa. Lubricin expression generally increased with increasing dose of ESWT. Increased lubricin expression may contribute to the beneficial effects of ESWT in providing pain and symptom relief in musculoskeletal disorders by decreasing erosive wear.</description><subject>Analysis</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cellular biology</subject><subject>Extracellular Matrix - metabolism</subject><subject>Gene expression</subject><subject>Glycoproteins</subject><subject>Glycoproteins - metabolism</subject><subject>High-Energy Shock Waves</subject><subject>Hindlimb - anatomy & histology</subject><subject>Hindlimb - cytology</subject><subject>Hindlimb - metabolism</subject><subject>Human Genetics</subject><subject>Intracellular Space - metabolism</subject><subject>Male</subject><subject>Molecular Medicine</subject><subject>Monoclonal antibodies</subject><subject>Proteomics</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Regular Article</subject><subject>Rodents</subject><subject>Staining and Labeling</subject><subject>Tendons</subject><subject>Tendons - 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metabolism</topic><topic>Gene expression</topic><topic>Glycoproteins</topic><topic>Glycoproteins - metabolism</topic><topic>High-Energy Shock Waves</topic><topic>Hindlimb - anatomy & histology</topic><topic>Hindlimb - cytology</topic><topic>Hindlimb - metabolism</topic><topic>Human Genetics</topic><topic>Intracellular Space - metabolism</topic><topic>Male</topic><topic>Molecular Medicine</topic><topic>Monoclonal antibodies</topic><topic>Proteomics</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Regular Article</topic><topic>Rodents</topic><topic>Staining and Labeling</topic><topic>Tendons</topic><topic>Tendons - cytology</topic><topic>Tendons - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Dafang</creatorcontrib><creatorcontrib>Kearney, Cathal J.</creatorcontrib><creatorcontrib>Cheriyan, Thomas</creatorcontrib><creatorcontrib>Schmid, Thomas M.</creatorcontrib><creatorcontrib>Spector, Myron</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><jtitle>Cell and tissue research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Dafang</au><au>Kearney, Cathal J.</au><au>Cheriyan, Thomas</au><au>Schmid, Thomas M.</au><au>Spector, Myron</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extracorporeal shockwave-induced expression of lubricin in tendons and septa</atitle><jtitle>Cell and tissue research</jtitle><stitle>Cell Tissue Res</stitle><addtitle>Cell Tissue Res</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>346</volume><issue>2</issue><spage>255</spage><epage>262</epage><pages>255-262</pages><issn>0302-766X</issn><eissn>1432-0878</eissn><abstract>Lubricin, a lubricating glycoprotein that facilitates tendon gliding, is upregulated by mechanical as well as biochemical stimuli, prompting this study of its induction by extracorporeal shockwave therapy (ESWT). The objective of this study was to characterize and quantify the effect of ESWT on lubricin expression in tendons and septa in a rat model. Hindlimbs of six rats were treated with low-dose ESWT and those of another six with high-dose ESWT, using contralateral limbs as controls. After 4 days, resected samples were processed for immunolocalization of lubricin using a purified monoclonal antibody. ESWT was found to increase lubricin expression in both low-dose and high-dose ESWT-treated tendons and also in septa. Lubricin expression generally increased with increasing dose of ESWT. Increased lubricin expression may contribute to the beneficial effects of ESWT in providing pain and symptom relief in musculoskeletal disorders by decreasing erosive wear.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22009294</pmid><doi>10.1007/s00441-011-1258-7</doi><tpages>8</tpages></addata></record> |
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| subjects | Analysis Animals Biomedical and Life Sciences Biomedicine Cellular biology Extracellular Matrix - metabolism Gene expression Glycoproteins Glycoproteins - metabolism High-Energy Shock Waves Hindlimb - anatomy & histology Hindlimb - cytology Hindlimb - metabolism Human Genetics Intracellular Space - metabolism Male Molecular Medicine Monoclonal antibodies Proteomics Rats Rats, Sprague-Dawley Regular Article Rodents Staining and Labeling Tendons Tendons - cytology Tendons - metabolism |
| title | Extracorporeal shockwave-induced expression of lubricin in tendons and septa |
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