Impact of Drug Conjugation on Pharmacokinetics and Tissue Distribution of Anti-STEAP1 Antibody–Drug Conjugates in Rats

Antibody–drug conjugates (ADCs) are designed to combine the exquisite specificity of antibodies to target tumor antigens with the cytotoxic potency of chemotherapeutic drugs. In addition to the general chemical stability of the linker, a thorough understanding of the relationship between ADC composi...

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Veröffentlicht in:	Bioconjugate chemistry 2011-10, Vol.22 (10), p.1994-2004
Hauptverfasser:	Boswell, C. Andrew, Mundo, Eduardo E, Zhang, Crystal, Bumbaca, Daniela, Valle, Nicole R, Kozak, Katherine R, Fourie, Aimee, Chuh, Josefa, Koppada, Neelima, Saad, Ola, Gill, Herman, Shen, Ben-Quan, Rubinfeld, Bonnee, Tibbitts, Jay, Kaur, Surinder, Theil, Frank-Peter, Fielder, Paul J, Khawli, Leslie A, Lin, Kedan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - blood Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - pharmacokinetics Antigens Antigens, Neoplasm - immunology Cancer Disulfides - chemistry Humans Immunoconjugates - blood Immunoconjugates - chemistry Immunoconjugates - pharmacokinetics Immunoglobulins Male Models, Molecular Oligopeptides - blood Oligopeptides - chemistry Oligopeptides - pharmacokinetics Oxidoreductases - immunology Pharmacokinetics Rats Rats, Sprague-Dawley Rodents Tissue Distribution Tissues Tumors
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