A potential mechanism of action of dietary anthocyanins: modulation of endothelial superoxide production by phenolic acid metabolites
[...] cyanidin-3-glucoside and protocatechuic acid did not appear to attenuate superoxide production at physiological concentrations, although both the glucuronide [87.9 (sd 4.1) and -1.4 (sd 18.9)% inhibition] and methyl 0.5 (sd 17.7) and 67.6 (sd 26.3)% inhibition conjugates of protocatechuic acid...
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| Veröffentlicht in: | Proceedings of the Nutrition Society 2011, Vol.70 (OCE4), Article E232 |
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| creator | Woodward, G. M. Cassidy, A. Kay, C. D. |
| description | [...] cyanidin-3-glucoside and protocatechuic acid did not appear to attenuate superoxide production at physiological concentrations, although both the glucuronide [87.9 (sd 4.1) and -1.4 (sd 18.9)% inhibition] and methyl 0.5 (sd 17.7) and 67.6 (sd 26.3)% inhibition conjugates of protocatechuic acid demonstrated significant inhibitory effects. [...] the ability of phenolic acids to inhibit superoxide release appeared to be inversely associated with the number of aryl hydroxyls ([left right arrow with stroke]OH=[arrow up]bioactivity), which was in express opposition to their antioxidant potential ([arrow up]OH=[arrow up]antioxidant potential), as established via Fe/ion reduction and xanthane oxidase inhibition assays. |
| doi_str_mv | 10.1017/S0029665111002837 |
| format | Article |
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| source | Cambridge University Press Journals Complete |
| subjects | Acids Antioxidants Metabolites Phenols |
| title | A potential mechanism of action of dietary anthocyanins: modulation of endothelial superoxide production by phenolic acid metabolites |
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