Polybrominated Diphenyl Ethers, Hydroxylated Polybrominated Diphenyl Ethers, and Measures of Thyroid Function in Second Trimester Pregnant Women in California
Prenatal exposure to polybrominated diphenyl ethers (PBDEs) may disrupt thyroid function and contribute to adverse neurodevelopmental outcomes. We conducted a pilot study to explore the relationship between serum concentrations of lower-brominated PBDEs (BDE-17 to -154), higher-brominated PBDEs (BDE...
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| Veröffentlicht in: | Environmental science & technology 2011-09, Vol.45 (18), p.7896-7905 |
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| creator | Zota, Ami R Park, June-Soo Wang, Yunzhu Petreas, Myrto Zoeller, R.Thomas Woodruff, Tracey J |
| description | Prenatal exposure to polybrominated diphenyl ethers (PBDEs) may disrupt thyroid function and contribute to adverse neurodevelopmental outcomes. We conducted a pilot study to explore the relationship between serum concentrations of lower-brominated PBDEs (BDE-17 to -154), higher-brominated PBDEs (BDE-183 to -209), and hydroxylated PBDE metabolites (OH-PBDEs) with measures of thyroid function in pregnant women. Concentrations of PBDEs, OH-PBDEs, thyroid-stimulating hormone (TSH), total thyroxine (T4), and free T4 were measured in serum samples collected between 2008 and 2009 from 25 second trimester pregnant women in California. Median concentrations of lower-brominated PBDEs and OH-PBDEs were the highest reported to date in pregnant women. Median concentrations of BDE-47 and the sum of lower-brominated PBDEs (ΣPBDE5) were 43.1 ng/g lipid and 85.8 ng/g lipid, respectively, and the sum of OH-PBDEs (ΣOH-PBDE4) was 0.084 ng/mL. We observed a positive association between the weighted sum of chemicals known to bind to transthyretin (ΣTTR binders) and TSH levels. We also found positive associations between TSH and ΣPBDE5, ΣOH-PBDE4, BDE-47, BDE-85, 5-OH-BDE47, and 4′-OH-BDE49, and an inverse association with BDE-207. Relationships with free and total T4 were weak and inconsistent. Our results indicate that PBDE exposures are elevated in pregnant women in California and suggest a relationship with thyroid function. Further investigation is warranted to characterize the risks of PBDE exposures during pregnancy. |
| doi_str_mv | 10.1021/es200422b |
| format | Article |
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We conducted a pilot study to explore the relationship between serum concentrations of lower-brominated PBDEs (BDE-17 to -154), higher-brominated PBDEs (BDE-183 to -209), and hydroxylated PBDE metabolites (OH-PBDEs) with measures of thyroid function in pregnant women. Concentrations of PBDEs, OH-PBDEs, thyroid-stimulating hormone (TSH), total thyroxine (T4), and free T4 were measured in serum samples collected between 2008 and 2009 from 25 second trimester pregnant women in California. Median concentrations of lower-brominated PBDEs and OH-PBDEs were the highest reported to date in pregnant women. Median concentrations of BDE-47 and the sum of lower-brominated PBDEs (ΣPBDE5) were 43.1 ng/g lipid and 85.8 ng/g lipid, respectively, and the sum of OH-PBDEs (ΣOH-PBDE4) was 0.084 ng/mL. We observed a positive association between the weighted sum of chemicals known to bind to transthyretin (ΣTTR binders) and TSH levels. We also found positive associations between TSH and ΣPBDE5, ΣOH-PBDE4, BDE-47, BDE-85, 5-OH-BDE47, and 4′-OH-BDE49, and an inverse association with BDE-207. Relationships with free and total T4 were weak and inconsistent. Our results indicate that PBDE exposures are elevated in pregnant women in California and suggest a relationship with thyroid function. Further investigation is warranted to characterize the risks of PBDE exposures during pregnancy.</description><identifier>ISSN: 0013-936X</identifier><identifier>EISSN: 1520-5851</identifier><identifier>DOI: 10.1021/es200422b</identifier><identifier>PMID: 21830753</identifier><identifier>CODEN: ESTHAG</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; California ; Chemical compounds ; Cross-Sectional Studies ; Ecotoxicology and Human Environmental Health ; Environmental Monitoring ; Environmental pollutants toxicology ; Female ; Flame Retardants - analysis ; General aspects ; Halogenated Diphenyl Ethers - blood ; Human exposure ; Humans ; Medical sciences ; Middle Aged ; Neurosciences ; PCB ; Pilot Projects ; Polybrominated diphenyl ethers ; Polychlorinated biphenyls ; Pregnancy ; Pregnancy - blood ; Pregnancy Trimester, Second - blood ; Prenatal development ; Thyroid diseases ; Thyroid gland ; Thyroid Gland - metabolism ; Thyrotropin - blood ; Thyroxine - blood ; Toxicology ; Young Adult</subject><ispartof>Environmental science & technology, 2011-09, Vol.45 (18), p.7896-7905</ispartof><rights>Copyright © 2011 American Chemical Society</rights><rights>2015 INIST-CNRS</rights><rights>Copyright American Chemical Society Sep 15, 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a472t-c129c4df9291db411e5d661b3a68015fb1db6685bb504a64b348de16926a5a7c3</citedby><cites>FETCH-LOGICAL-a472t-c129c4df9291db411e5d661b3a68015fb1db6685bb504a64b348de16926a5a7c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/es200422b$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/es200422b$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24520602$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21830753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zota, Ami R</creatorcontrib><creatorcontrib>Park, June-Soo</creatorcontrib><creatorcontrib>Wang, Yunzhu</creatorcontrib><creatorcontrib>Petreas, Myrto</creatorcontrib><creatorcontrib>Zoeller, R.Thomas</creatorcontrib><creatorcontrib>Woodruff, Tracey J</creatorcontrib><title>Polybrominated Diphenyl Ethers, Hydroxylated Polybrominated Diphenyl Ethers, and Measures of Thyroid Function in Second Trimester Pregnant Women in California</title><title>Environmental science & technology</title><addtitle>Environ. Sci. Technol</addtitle><description>Prenatal exposure to polybrominated diphenyl ethers (PBDEs) may disrupt thyroid function and contribute to adverse neurodevelopmental outcomes. We conducted a pilot study to explore the relationship between serum concentrations of lower-brominated PBDEs (BDE-17 to -154), higher-brominated PBDEs (BDE-183 to -209), and hydroxylated PBDE metabolites (OH-PBDEs) with measures of thyroid function in pregnant women. Concentrations of PBDEs, OH-PBDEs, thyroid-stimulating hormone (TSH), total thyroxine (T4), and free T4 were measured in serum samples collected between 2008 and 2009 from 25 second trimester pregnant women in California. Median concentrations of lower-brominated PBDEs and OH-PBDEs were the highest reported to date in pregnant women. Median concentrations of BDE-47 and the sum of lower-brominated PBDEs (ΣPBDE5) were 43.1 ng/g lipid and 85.8 ng/g lipid, respectively, and the sum of OH-PBDEs (ΣOH-PBDE4) was 0.084 ng/mL. We observed a positive association between the weighted sum of chemicals known to bind to transthyretin (ΣTTR binders) and TSH levels. We also found positive associations between TSH and ΣPBDE5, ΣOH-PBDE4, BDE-47, BDE-85, 5-OH-BDE47, and 4′-OH-BDE49, and an inverse association with BDE-207. Relationships with free and total T4 were weak and inconsistent. Our results indicate that PBDE exposures are elevated in pregnant women in California and suggest a relationship with thyroid function. Further investigation is warranted to characterize the risks of PBDE exposures during pregnancy.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>California</subject><subject>Chemical compounds</subject><subject>Cross-Sectional Studies</subject><subject>Ecotoxicology and Human Environmental Health</subject><subject>Environmental Monitoring</subject><subject>Environmental pollutants toxicology</subject><subject>Female</subject><subject>Flame Retardants - analysis</subject><subject>General aspects</subject><subject>Halogenated Diphenyl Ethers - blood</subject><subject>Human exposure</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurosciences</subject><subject>PCB</subject><subject>Pilot Projects</subject><subject>Polybrominated diphenyl ethers</subject><subject>Polychlorinated biphenyls</subject><subject>Pregnancy</subject><subject>Pregnancy - blood</subject><subject>Pregnancy Trimester, Second - blood</subject><subject>Prenatal development</subject><subject>Thyroid diseases</subject><subject>Thyroid gland</subject><subject>Thyroid Gland - metabolism</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - blood</subject><subject>Toxicology</subject><subject>Young Adult</subject><issn>0013-936X</issn><issn>1520-5851</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0ctO3DAUBmCrKirDZdEXQFalLpAI2I7tSZZoyk0CFalT0V10fAljlLEHO5HIy_CsuDAMiy66smR_PufYP0JfKTmmhNETmxghnDH1CU2oYKQQlaCf0YQQWhZ1Kf9so52UHgghrCTVF7TNaFWSqSgn6Pk2dKOKYek89NbgH261sH7s8Fm_sDEd4cvRxPA0dq-n_8PgDb6xkIZoEw4tni_GGJzB54PXvQseO49_WR0ym0e3tKm3Ed9Ge-_B9_guLO0rmUHn2hC9gz201UKX7P563UW_z8_ms8vi-ufF1ez0ugA-ZX2hKas1N23NamoUp9QKIyVVJciKUNGqvCtlJZQShIPkquSVsVTWTIKAqS530be3uqsYHoc8V_MQhuhzy6aqpzxfrURGh29Ix5BStG2zyo-AODaUNH-DaDZBZHuwLjiopTUb-f7zGXxfA0gaujaC1y59OJ5zlDmvjQOdPob6t-EL0AOeXQ</recordid><startdate>20110915</startdate><enddate>20110915</enddate><creator>Zota, Ami R</creator><creator>Park, June-Soo</creator><creator>Wang, Yunzhu</creator><creator>Petreas, Myrto</creator><creator>Zoeller, R.Thomas</creator><creator>Woodruff, Tracey J</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7ST</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>SOI</scope></search><sort><creationdate>20110915</creationdate><title>Polybrominated Diphenyl Ethers, Hydroxylated Polybrominated Diphenyl Ethers, and Measures of Thyroid Function in Second Trimester Pregnant Women in California</title><author>Zota, Ami R ; Park, June-Soo ; Wang, Yunzhu ; Petreas, Myrto ; Zoeller, R.Thomas ; Woodruff, Tracey J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a472t-c129c4df9291db411e5d661b3a68015fb1db6685bb504a64b348de16926a5a7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>California</topic><topic>Chemical compounds</topic><topic>Cross-Sectional Studies</topic><topic>Ecotoxicology and Human Environmental Health</topic><topic>Environmental Monitoring</topic><topic>Environmental pollutants toxicology</topic><topic>Female</topic><topic>Flame Retardants - analysis</topic><topic>General aspects</topic><topic>Halogenated Diphenyl Ethers - blood</topic><topic>Human exposure</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurosciences</topic><topic>PCB</topic><topic>Pilot Projects</topic><topic>Polybrominated diphenyl ethers</topic><topic>Polychlorinated biphenyls</topic><topic>Pregnancy</topic><topic>Pregnancy - blood</topic><topic>Pregnancy Trimester, Second - blood</topic><topic>Prenatal development</topic><topic>Thyroid diseases</topic><topic>Thyroid gland</topic><topic>Thyroid Gland - metabolism</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - blood</topic><topic>Toxicology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zota, Ami R</creatorcontrib><creatorcontrib>Park, June-Soo</creatorcontrib><creatorcontrib>Wang, Yunzhu</creatorcontrib><creatorcontrib>Petreas, Myrto</creatorcontrib><creatorcontrib>Zoeller, R.Thomas</creatorcontrib><creatorcontrib>Woodruff, Tracey J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Environmental science & technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zota, Ami R</au><au>Park, June-Soo</au><au>Wang, Yunzhu</au><au>Petreas, Myrto</au><au>Zoeller, R.Thomas</au><au>Woodruff, Tracey J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polybrominated Diphenyl Ethers, Hydroxylated Polybrominated Diphenyl Ethers, and Measures of Thyroid Function in Second Trimester Pregnant Women in California</atitle><jtitle>Environmental science & technology</jtitle><addtitle>Environ. Sci. Technol</addtitle><date>2011-09-15</date><risdate>2011</risdate><volume>45</volume><issue>18</issue><spage>7896</spage><epage>7905</epage><pages>7896-7905</pages><issn>0013-936X</issn><eissn>1520-5851</eissn><coden>ESTHAG</coden><abstract>Prenatal exposure to polybrominated diphenyl ethers (PBDEs) may disrupt thyroid function and contribute to adverse neurodevelopmental outcomes. We conducted a pilot study to explore the relationship between serum concentrations of lower-brominated PBDEs (BDE-17 to -154), higher-brominated PBDEs (BDE-183 to -209), and hydroxylated PBDE metabolites (OH-PBDEs) with measures of thyroid function in pregnant women. Concentrations of PBDEs, OH-PBDEs, thyroid-stimulating hormone (TSH), total thyroxine (T4), and free T4 were measured in serum samples collected between 2008 and 2009 from 25 second trimester pregnant women in California. Median concentrations of lower-brominated PBDEs and OH-PBDEs were the highest reported to date in pregnant women. Median concentrations of BDE-47 and the sum of lower-brominated PBDEs (ΣPBDE5) were 43.1 ng/g lipid and 85.8 ng/g lipid, respectively, and the sum of OH-PBDEs (ΣOH-PBDE4) was 0.084 ng/mL. We observed a positive association between the weighted sum of chemicals known to bind to transthyretin (ΣTTR binders) and TSH levels. We also found positive associations between TSH and ΣPBDE5, ΣOH-PBDE4, BDE-47, BDE-85, 5-OH-BDE47, and 4′-OH-BDE49, and an inverse association with BDE-207. Relationships with free and total T4 were weak and inconsistent. Our results indicate that PBDE exposures are elevated in pregnant women in California and suggest a relationship with thyroid function. Further investigation is warranted to characterize the risks of PBDE exposures during pregnancy.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>21830753</pmid><doi>10.1021/es200422b</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Biological and medical sciences California Chemical compounds Cross-Sectional Studies Ecotoxicology and Human Environmental Health Environmental Monitoring Environmental pollutants toxicology Female Flame Retardants - analysis General aspects Halogenated Diphenyl Ethers - blood Human exposure Humans Medical sciences Middle Aged Neurosciences PCB Pilot Projects Polybrominated diphenyl ethers Polychlorinated biphenyls Pregnancy Pregnancy - blood Pregnancy Trimester, Second - blood Prenatal development Thyroid diseases Thyroid gland Thyroid Gland - metabolism Thyrotropin - blood Thyroxine - blood Toxicology Young Adult |
| title | Polybrominated Diphenyl Ethers, Hydroxylated Polybrominated Diphenyl Ethers, and Measures of Thyroid Function in Second Trimester Pregnant Women in California |
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