External and Near-Nozzle Spray Characteristics of a Continuous Spray Atomized from a Nasal Spray Device
Computational fluid dynamics (CFD) simulations of nasal drug delivery often neglect the initial spray particle conditions (e.g., particle velocity) and instead introduce particles entrained by the inhaled airflow into the nasal cavity. The results presented in this study aim to provide some insight...
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Veröffentlicht in: | Aerosol science and technology 2012-02, Vol.46 (2), p.165-177 |
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description | Computational fluid dynamics (CFD) simulations of nasal drug delivery often neglect the initial spray particle conditions (e.g., particle velocity) and instead introduce particles entrained by the inhaled airflow into the nasal cavity. The results presented in this study aim to provide some insight into spray droplet formation after atomization of a drug formulation from a nasal spray device. A commercial nasal spray device was tested under a constant flow in order to better understand its spray formation and characteristics. External characteristics such as the spray cone angle define the shape of the atomized spray that exits from the device, while the internal characteristics such as the droplet size distribution help to determine the likelihood of inertial impaction within the nasal cavity. The experimental method makes use of particle image velocimetry (PIV) and particle/droplet image analysis (PDIA) to obtain droplet diameters and spray velocities in different spray regions. Image processing techniques were applied to enhance visualization and a droplet concentration field. It was shown that there is some variation in the droplet diameters with respect to its radial and axial position from the spray orifice. Empirical curve fits for the particle size distribution were formulated to allow easier adoption of the data into CFD models. The dimensions of the external spray were shown to be much larger in comparison with the dimensions of a nasal cavity, which means that only a narrow portion of the spray will fit within the narrow cross sections of the nasal cavity. The results may be used for the validation of spray atomization models and applied to the particle deposition study of sprayed particles in nasal cavity in future.
Copyright 2012 American Association for Aerosol Research |
doi_str_mv | 10.1080/02786826.2011.617793 |
format | Article |
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Copyright 2012 American Association for Aerosol Research</description><identifier>ISSN: 0278-6826</identifier><identifier>EISSN: 1521-7388</identifier><identifier>DOI: 10.1080/02786826.2011.617793</identifier><identifier>CODEN: ASTYDQ</identifier><language>eng</language><publisher>Colchester: Taylor & Francis Group</publisher><subject>Aerosols ; Chemistry ; Colloidal state and disperse state ; Exact sciences and technology ; Flow velocity ; Fluid dynamics ; General and physical chemistry ; Grain size ; Simulation</subject><ispartof>Aerosol science and technology, 2012-02, Vol.46 (2), p.165-177</ispartof><rights>Copyright Taylor & Francis Group, LLC 2012</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Taylor & Francis Ltd. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-8530415ab814252aaf64563a3e1de5482e87c25897af9d88842fcd38342a23433</citedby><cites>FETCH-LOGICAL-c447t-8530415ab814252aaf64563a3e1de5482e87c25897af9d88842fcd38342a23433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25772449$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Inthavong, K.</creatorcontrib><creatorcontrib>Yang, W.</creatorcontrib><creatorcontrib>Fung, M. C.</creatorcontrib><creatorcontrib>Tu, J. Y.</creatorcontrib><title>External and Near-Nozzle Spray Characteristics of a Continuous Spray Atomized from a Nasal Spray Device</title><title>Aerosol science and technology</title><description>Computational fluid dynamics (CFD) simulations of nasal drug delivery often neglect the initial spray particle conditions (e.g., particle velocity) and instead introduce particles entrained by the inhaled airflow into the nasal cavity. The results presented in this study aim to provide some insight into spray droplet formation after atomization of a drug formulation from a nasal spray device. A commercial nasal spray device was tested under a constant flow in order to better understand its spray formation and characteristics. External characteristics such as the spray cone angle define the shape of the atomized spray that exits from the device, while the internal characteristics such as the droplet size distribution help to determine the likelihood of inertial impaction within the nasal cavity. The experimental method makes use of particle image velocimetry (PIV) and particle/droplet image analysis (PDIA) to obtain droplet diameters and spray velocities in different spray regions. Image processing techniques were applied to enhance visualization and a droplet concentration field. It was shown that there is some variation in the droplet diameters with respect to its radial and axial position from the spray orifice. Empirical curve fits for the particle size distribution were formulated to allow easier adoption of the data into CFD models. The dimensions of the external spray were shown to be much larger in comparison with the dimensions of a nasal cavity, which means that only a narrow portion of the spray will fit within the narrow cross sections of the nasal cavity. The results may be used for the validation of spray atomization models and applied to the particle deposition study of sprayed particles in nasal cavity in future.
Copyright 2012 American Association for Aerosol Research</description><subject>Aerosols</subject><subject>Chemistry</subject><subject>Colloidal state and disperse state</subject><subject>Exact sciences and technology</subject><subject>Flow velocity</subject><subject>Fluid dynamics</subject><subject>General and physical chemistry</subject><subject>Grain size</subject><subject>Simulation</subject><issn>0278-6826</issn><issn>1521-7388</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp90LtOwzAYBWALgUQpvAFDhMSY4ltiZ0IolItUlQGYrR_HhlRJXOwEaJ-eRGkZmTz4O8fyQeic4BnBEl9hKmQqaTqjmJBZSoTI2AGakISSWDApD9FkIPFgjtFJCCuMMRGUTND7_Kc1voEqgqaIlgZ8vHTbbWWi57WHTZR_gAfdkzK0pQ6RsxFEuWvasulcF3bqpnV1uTVFZL2re7CE0DeOd7fmq9TmFB1ZqII5251T9Ho3f8kf4sXT_WN-s4g156KNZcIwJwm8ScJpQgFsypOUATOkMAmX1EihaSIzATYrpJScWl0wyTgFyjhjU3Qx9q69--xMaNXKdcP_gupDPJWMyh7xEWnvQvDGqrUva_AbRbAaFlX7RdWwqBoX7WOXu24IGirrodFl-MvSRAjKeda769GVjXW-hm_nq0K1sKmc34fYvy_9AkSTiJ8</recordid><startdate>201202</startdate><enddate>201202</enddate><creator>Inthavong, K.</creator><creator>Yang, W.</creator><creator>Fung, M. 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Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-8530415ab814252aaf64563a3e1de5482e87c25897af9d88842fcd38342a23433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aerosols</topic><topic>Chemistry</topic><topic>Colloidal state and disperse state</topic><topic>Exact sciences and technology</topic><topic>Flow velocity</topic><topic>Fluid dynamics</topic><topic>General and physical chemistry</topic><topic>Grain size</topic><topic>Simulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inthavong, K.</creatorcontrib><creatorcontrib>Yang, W.</creatorcontrib><creatorcontrib>Fung, M. C.</creatorcontrib><creatorcontrib>Tu, J. Y.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><jtitle>Aerosol science and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inthavong, K.</au><au>Yang, W.</au><au>Fung, M. C.</au><au>Tu, J. Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>External and Near-Nozzle Spray Characteristics of a Continuous Spray Atomized from a Nasal Spray Device</atitle><jtitle>Aerosol science and technology</jtitle><date>2012-02</date><risdate>2012</risdate><volume>46</volume><issue>2</issue><spage>165</spage><epage>177</epage><pages>165-177</pages><issn>0278-6826</issn><eissn>1521-7388</eissn><coden>ASTYDQ</coden><abstract>Computational fluid dynamics (CFD) simulations of nasal drug delivery often neglect the initial spray particle conditions (e.g., particle velocity) and instead introduce particles entrained by the inhaled airflow into the nasal cavity. The results presented in this study aim to provide some insight into spray droplet formation after atomization of a drug formulation from a nasal spray device. A commercial nasal spray device was tested under a constant flow in order to better understand its spray formation and characteristics. External characteristics such as the spray cone angle define the shape of the atomized spray that exits from the device, while the internal characteristics such as the droplet size distribution help to determine the likelihood of inertial impaction within the nasal cavity. The experimental method makes use of particle image velocimetry (PIV) and particle/droplet image analysis (PDIA) to obtain droplet diameters and spray velocities in different spray regions. Image processing techniques were applied to enhance visualization and a droplet concentration field. It was shown that there is some variation in the droplet diameters with respect to its radial and axial position from the spray orifice. Empirical curve fits for the particle size distribution were formulated to allow easier adoption of the data into CFD models. The dimensions of the external spray were shown to be much larger in comparison with the dimensions of a nasal cavity, which means that only a narrow portion of the spray will fit within the narrow cross sections of the nasal cavity. The results may be used for the validation of spray atomization models and applied to the particle deposition study of sprayed particles in nasal cavity in future.
Copyright 2012 American Association for Aerosol Research</abstract><cop>Colchester</cop><pub>Taylor & Francis Group</pub><doi>10.1080/02786826.2011.617793</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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source | IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
subjects | Aerosols Chemistry Colloidal state and disperse state Exact sciences and technology Flow velocity Fluid dynamics General and physical chemistry Grain size Simulation |
title | External and Near-Nozzle Spray Characteristics of a Continuous Spray Atomized from a Nasal Spray Device |
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