Antidiabetic actions of a non-agonist PPAR[gamma] ligand blocking Cdk5-mediated phosphorylation

PPARγ is the functioning receptor for the thiazolidinedione (TZD) class of antidiabetes drugs including rosiglitazone and pioglitazone. These drugs are full classical agonists for this nuclear receptor, but recent data have shown that many PPARγ-based drugs have a separate biochemical activity, bloc...

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Veröffentlicht in:	Nature (London) 2011-09, Vol.477 (7365), p.477
Hauptverfasser:	Choi, Jang Hyun, Banks, Alexander S, Kamenecka, Theodore M, Busby, Scott A, Chalmers, Michael J, Kumar, Naresh, Kuruvilla, Dana S, Shin, Youseung, He, Yuanjun, Bruning, John B, Marciano, David P, Cameron, Michael D, Laznik, Dina, Jurczak, Michael J, Schürer, Stephan C, Vidovic, Dusica, Shulman, Gerald I, Spiegelman, Bruce M, Griffin, Patrick R
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone density Kinases Proteins Rodents Side effects
Online-Zugang:	Volltext
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