CARD15 and TLR4 polymorphisms in atopic bronchial asthma
In order to investigate whether single nucleotide polymorphisms G(+2722)C and 3020insC of CARD15 and Asp299Gly of TLR4 contribute to atopic bronchial asthma, we performed a comparative analysis of allele and genotype frequencies of these polymorphisms in Russian patients from Moscow. DNA specimens o...
Gespeichert in:
| Veröffentlicht in: | Molecular biology (New York) 2011-10, Vol.45 (5), p.766-773 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 773 |
|---|---|
| container_issue | 5 |
| container_start_page | 766 |
| container_title | Molecular biology (New York) |
| container_volume | 45 |
| creator | Voronko, O. E. Dmitrieva-Zdorova, E. V. Latysheva, E. A. Aksenova, M. G. Storozhakov, G. I. Bodoev, N. V. Archakov, A. I. |
| description | In order to investigate whether single nucleotide polymorphisms G(+2722)C and 3020insC of
CARD15
and Asp299Gly of
TLR4
contribute to atopic bronchial asthma, we performed a comparative analysis of allele and genotype frequencies of these polymorphisms in Russian patients from Moscow. DNA specimens obtained from 283 patients with atopic bronchial asthma and 227 healthy donors were genotyped. Neither G(+2722)C or 3020insC in
CARD15
nor Asp299Gly in
TLR4
were associated with asthma;
CARD15
polymorphisms were not also associated with asthma severity. A haplotype frequency analysis of
CARD15
polymorphisms did not detect significant differences between the groups studied. However, a strong association was found between Asp299Gly and asthma course: the Asp allele was associated with mild disease, while the minor Gly allele was associated with moderate/severe asthma (
OR
= 0.47, 95% CI [0.24–0.93] and
OR
= 2.12, 95% CI [1.08–4.18], respectively). |
| doi_str_mv | 10.1134/S0026893311040121 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_896670354</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2478998211</sourcerecordid><originalsourceid>FETCH-LOGICAL-c267t-fb630ec9e886e44b19359d21912cea0bfdddba7e1513e71b891c1652eeba3eab3</originalsourceid><addsrcrecordid>eNp1kEFLAzEUhIMoWKs_wFvwvpqXZLPJsVStQkGo9bwk2bd2S3ezJttD_71bKngQ4cEcZr55MITcArsHEPLhnTGutBECgEkGHM7IBBTTmeAyPyeTo50d_UtyldKWMRiPT4iez1aPkFPbVXS9XEnah92hDbHfNKlNtOmoHULfeOpi6PymsTtq07Bp7TW5qO0u4c2PTsnH89N6_pIt3xav89ky81wVQ1Y7JRh6g1orlNKBEbmpOBjgHi1zdVVVzhYIOQgswGkDHlTOEZ0VaJ2YkrtTbx_D1x7TUG7DPnbjy1IbpQomcjmG4BTyMaQUsS772LQ2Hkpg5XGf8s8-I8NPTBqz3SfG3-L_oW8VrWVa</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>896670354</pqid></control><display><type>article</type><title>CARD15 and TLR4 polymorphisms in atopic bronchial asthma</title><source>SpringerLink Journals</source><creator>Voronko, O. E. ; Dmitrieva-Zdorova, E. V. ; Latysheva, E. A. ; Aksenova, M. G. ; Storozhakov, G. I. ; Bodoev, N. V. ; Archakov, A. I.</creator><creatorcontrib>Voronko, O. E. ; Dmitrieva-Zdorova, E. V. ; Latysheva, E. A. ; Aksenova, M. G. ; Storozhakov, G. I. ; Bodoev, N. V. ; Archakov, A. I.</creatorcontrib><description>In order to investigate whether single nucleotide polymorphisms G(+2722)C and 3020insC of
CARD15
and Asp299Gly of
TLR4
contribute to atopic bronchial asthma, we performed a comparative analysis of allele and genotype frequencies of these polymorphisms in Russian patients from Moscow. DNA specimens obtained from 283 patients with atopic bronchial asthma and 227 healthy donors were genotyped. Neither G(+2722)C or 3020insC in
CARD15
nor Asp299Gly in
TLR4
were associated with asthma;
CARD15
polymorphisms were not also associated with asthma severity. A haplotype frequency analysis of
CARD15
polymorphisms did not detect significant differences between the groups studied. However, a strong association was found between Asp299Gly and asthma course: the Asp allele was associated with mild disease, while the minor Gly allele was associated with moderate/severe asthma (
OR
= 0.47, 95% CI [0.24–0.93] and
OR
= 2.12, 95% CI [1.08–4.18], respectively).</description><identifier>ISSN: 0026-8933</identifier><identifier>EISSN: 1608-3245</identifier><identifier>DOI: 10.1134/S0026893311040121</identifier><language>eng</language><publisher>Dordrecht: SP MAIK Nauka/Interperiodica</publisher><subject>Asthma ; Biochemistry ; Biomedical and Life Sciences ; Genomics. Transcriptomics ; Genotype & phenotype ; Haplotypes ; Human Genetics ; Life Sciences ; Minority & ethnic groups ; Molecular biology ; Polymorphism</subject><ispartof>Molecular biology (New York), 2011-10, Vol.45 (5), p.766-773</ispartof><rights>Pleiades Publishing, Ltd. 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c267t-fb630ec9e886e44b19359d21912cea0bfdddba7e1513e71b891c1652eeba3eab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S0026893311040121$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S0026893311040121$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Voronko, O. E.</creatorcontrib><creatorcontrib>Dmitrieva-Zdorova, E. V.</creatorcontrib><creatorcontrib>Latysheva, E. A.</creatorcontrib><creatorcontrib>Aksenova, M. G.</creatorcontrib><creatorcontrib>Storozhakov, G. I.</creatorcontrib><creatorcontrib>Bodoev, N. V.</creatorcontrib><creatorcontrib>Archakov, A. I.</creatorcontrib><title>CARD15 and TLR4 polymorphisms in atopic bronchial asthma</title><title>Molecular biology (New York)</title><addtitle>Mol Biol</addtitle><description>In order to investigate whether single nucleotide polymorphisms G(+2722)C and 3020insC of
CARD15
and Asp299Gly of
TLR4
contribute to atopic bronchial asthma, we performed a comparative analysis of allele and genotype frequencies of these polymorphisms in Russian patients from Moscow. DNA specimens obtained from 283 patients with atopic bronchial asthma and 227 healthy donors were genotyped. Neither G(+2722)C or 3020insC in
CARD15
nor Asp299Gly in
TLR4
were associated with asthma;
CARD15
polymorphisms were not also associated with asthma severity. A haplotype frequency analysis of
CARD15
polymorphisms did not detect significant differences between the groups studied. However, a strong association was found between Asp299Gly and asthma course: the Asp allele was associated with mild disease, while the minor Gly allele was associated with moderate/severe asthma (
OR
= 0.47, 95% CI [0.24–0.93] and
OR
= 2.12, 95% CI [1.08–4.18], respectively).</description><subject>Asthma</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Genomics. Transcriptomics</subject><subject>Genotype & phenotype</subject><subject>Haplotypes</subject><subject>Human Genetics</subject><subject>Life Sciences</subject><subject>Minority & ethnic groups</subject><subject>Molecular biology</subject><subject>Polymorphism</subject><issn>0026-8933</issn><issn>1608-3245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kEFLAzEUhIMoWKs_wFvwvpqXZLPJsVStQkGo9bwk2bd2S3ezJttD_71bKngQ4cEcZr55MITcArsHEPLhnTGutBECgEkGHM7IBBTTmeAyPyeTo50d_UtyldKWMRiPT4iez1aPkFPbVXS9XEnah92hDbHfNKlNtOmoHULfeOpi6PymsTtq07Bp7TW5qO0u4c2PTsnH89N6_pIt3xav89ky81wVQ1Y7JRh6g1orlNKBEbmpOBjgHi1zdVVVzhYIOQgswGkDHlTOEZ0VaJ2YkrtTbx_D1x7TUG7DPnbjy1IbpQomcjmG4BTyMaQUsS772LQ2Hkpg5XGf8s8-I8NPTBqz3SfG3-L_oW8VrWVa</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Voronko, O. E.</creator><creator>Dmitrieva-Zdorova, E. V.</creator><creator>Latysheva, E. A.</creator><creator>Aksenova, M. G.</creator><creator>Storozhakov, G. I.</creator><creator>Bodoev, N. V.</creator><creator>Archakov, A. I.</creator><general>SP MAIK Nauka/Interperiodica</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope></search><sort><creationdate>20111001</creationdate><title>CARD15 and TLR4 polymorphisms in atopic bronchial asthma</title><author>Voronko, O. E. ; Dmitrieva-Zdorova, E. V. ; Latysheva, E. A. ; Aksenova, M. G. ; Storozhakov, G. I. ; Bodoev, N. V. ; Archakov, A. I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c267t-fb630ec9e886e44b19359d21912cea0bfdddba7e1513e71b891c1652eeba3eab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Asthma</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Genomics. Transcriptomics</topic><topic>Genotype & phenotype</topic><topic>Haplotypes</topic><topic>Human Genetics</topic><topic>Life Sciences</topic><topic>Minority & ethnic groups</topic><topic>Molecular biology</topic><topic>Polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Voronko, O. E.</creatorcontrib><creatorcontrib>Dmitrieva-Zdorova, E. V.</creatorcontrib><creatorcontrib>Latysheva, E. A.</creatorcontrib><creatorcontrib>Aksenova, M. G.</creatorcontrib><creatorcontrib>Storozhakov, G. I.</creatorcontrib><creatorcontrib>Bodoev, N. V.</creatorcontrib><creatorcontrib>Archakov, A. I.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><jtitle>Molecular biology (New York)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Voronko, O. E.</au><au>Dmitrieva-Zdorova, E. V.</au><au>Latysheva, E. A.</au><au>Aksenova, M. G.</au><au>Storozhakov, G. I.</au><au>Bodoev, N. V.</au><au>Archakov, A. I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CARD15 and TLR4 polymorphisms in atopic bronchial asthma</atitle><jtitle>Molecular biology (New York)</jtitle><stitle>Mol Biol</stitle><date>2011-10-01</date><risdate>2011</risdate><volume>45</volume><issue>5</issue><spage>766</spage><epage>773</epage><pages>766-773</pages><issn>0026-8933</issn><eissn>1608-3245</eissn><abstract>In order to investigate whether single nucleotide polymorphisms G(+2722)C and 3020insC of
CARD15
and Asp299Gly of
TLR4
contribute to atopic bronchial asthma, we performed a comparative analysis of allele and genotype frequencies of these polymorphisms in Russian patients from Moscow. DNA specimens obtained from 283 patients with atopic bronchial asthma and 227 healthy donors were genotyped. Neither G(+2722)C or 3020insC in
CARD15
nor Asp299Gly in
TLR4
were associated with asthma;
CARD15
polymorphisms were not also associated with asthma severity. A haplotype frequency analysis of
CARD15
polymorphisms did not detect significant differences between the groups studied. However, a strong association was found between Asp299Gly and asthma course: the Asp allele was associated with mild disease, while the minor Gly allele was associated with moderate/severe asthma (
OR
= 0.47, 95% CI [0.24–0.93] and
OR
= 2.12, 95% CI [1.08–4.18], respectively).</abstract><cop>Dordrecht</cop><pub>SP MAIK Nauka/Interperiodica</pub><doi>10.1134/S0026893311040121</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0026-8933 |
| ispartof | Molecular biology (New York), 2011-10, Vol.45 (5), p.766-773 |
| issn | 0026-8933 1608-3245 |
| language | eng |
| recordid | cdi_proquest_journals_896670354 |
| source | SpringerLink Journals |
| subjects | Asthma Biochemistry Biomedical and Life Sciences Genomics. Transcriptomics Genotype & phenotype Haplotypes Human Genetics Life Sciences Minority & ethnic groups Molecular biology Polymorphism |
| title | CARD15 and TLR4 polymorphisms in atopic bronchial asthma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T03%3A56%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=CARD15%20and%20TLR4%20polymorphisms%20in%20atopic%20bronchial%20asthma&rft.jtitle=Molecular%20biology%20(New%20York)&rft.au=Voronko,%20O.%20E.&rft.date=2011-10-01&rft.volume=45&rft.issue=5&rft.spage=766&rft.epage=773&rft.pages=766-773&rft.issn=0026-8933&rft.eissn=1608-3245&rft_id=info:doi/10.1134/S0026893311040121&rft_dat=%3Cproquest_cross%3E2478998211%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=896670354&rft_id=info:pmid/&rfr_iscdi=true |